Preeclampsia: A Multifactorial Disease Resulting from the Interaction of the Feto‐maternal HLA Genotype and HCMV Infection

Carreiras, Milagros M.; Montagnani, S.; Layrisse, Z.

doi:10.1034/j.1600-0897.2002.01076.x

Cited by 51 publications

(43 citation statements)

References 40 publications

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“…On the other hand, Hviid et al [58] genotyped 61 RSA couples and 47 fertile control couples and did not observe any significant differences in the distribution of the above HLA-G alleles. The analysis of variations in the HLA-G gene exons also was addressed regarding PE: A study by Carreiras et al [74] observed a preferential inheritance of maternal G*0104 alleles among 25 PE mother-child pairs. This result was not observed in a Danish study including 57 family triads (offspring and parents) with PE and 98 control families, in which no obvious differences were observed in the distribution of the HLA-G alleles [62].…”

Section: Discussionmentioning

confidence: 99%

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

Moreau

Contu

Alba³

et al. 2008

Biology of Reproduction

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Definite causes for several pathologies of pregnancy remain unknown. In light of several recent studies, however, diminished or aberrant HLA-G expression may be associated with certain complication of pregnancy and be linked to HLA-G polymorphism. We analyzed DNA from 60 normal placentas (controls), 140 placentas from miscarriage, 36 placentas from preeclampsia, 76 placentas from fetal hypotrophy, and 34 placentas with hypoxia for variations in coding regions (allelic groups G*0101 to G*0107) and the 14-bp deletion/insertion into the 3'-untranslated region. No statistically significant differences were observed in the distribution of allelic group between pathological placentas and controls with the exception of G*0106 allele frequency in preeclamptic compared with control placentas (21.2% and 6.6%, respectively). A greater frequency of this allele also was observed in the two subgroups of miscarriage and hypoxia compared with that in controls. In addition, presence of the 14-bp sequence was prominent in preeclampsia compared with controls (60.8% vs. 35%, respectively), and homozygotes with deletion were not detected in the pathology. The results suggest that the G*0106 allele, which is coupled with the presence of the 14-bp sequence, contributes and/or is a relevant marker in some specific complications of pregnancy, especially preeclampsia.

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Section: Discussionmentioning

confidence: 99%

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

Moreau

Contu

Alba³

et al. 2008

Biology of Reproduction

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“…Various small studies have linked disorders of pregnancy such as recurrent miscarriage [21,22] and preeclampsia [23,24] with HLA-G, but the alleles implicated vary, and several studies found no associations [25][26][27]. Because much of the limited polymorphism is in untranslated regions or encodes synonymous changes, associations are also of uncertain significance until biological mechanisms are described that might underlie the genetic findings.…”

Section: Disease Association Studiesmentioning

confidence: 92%

A critical look at HLA-G

Apps

Gardner

Moffett

2008

Trends in Immunology

194

150

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“…HCMV is associated with several vascular diseases, including atherosclerosis, coronary heart disease, and vasculopathy [5][6][7]. During pregnancy, HCMV infections have also been associated with the hypertensive disorder preeclampsia [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Impact of Local Endothelial Challenge with Cytomegalovirus or Glycoprotein B on Vasodilation in Intact Pressurized Arteries from Nonpregnant and Pregnant Mice1

Gombos

Teefy

Lee

et al. 2012

Biology of Reproduction

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Cytomegalovirus (CMV) infections are associated with vascular diseases in the human population. We have previously shown vascular dysfunction in systemic and uterine arteries dissected from nonpregnant (NP) mouse CMV (mCMV)-infected mice that was further impaired during late pregnancy (LP). CMV attachment alone through glycoprotein B (GB) can generate signals that impact vascular tone regulation. However, the contribution of direct virus interactions with endothelium to the vascular dysfunction we previously observed after in vivo mCMV infection is not known. We used a pressure myograph system to infuse GB or whole intact mCMV inside arteries dissected from uninfected mice and assessed vasodilation to methacholine infused inside pressurized arteries rather than applied abluminally. These results were compared to those observed after methacholine infusion into untreated arteries dissected from mCMV-infected mice. In mesenteric arteries, vasodilation to infused methacholine did not differ among treatments in NP or LP groups in contrast to previously published studies. However, increased vasoconstrictor activity was unmasked after blocking thromboxane receptors or prostaglandin production. Vasodilation in uterine arteries from uninfected NP mice to infused methacholine was increased by both GB and whole intact mCMV pretreatment. Untreated uterine arteries from mCMV-infected NP mice showed even greater vasodilation. There was no effect of GB or whole intact mCMV pretreatment in uterine arteries from uninfected LP mice, whereas vasodilation to infused methacholine was reduced in untreated uterine arteries from mCMV-infected LP mice. CMV exerts direct effects on vascular function which should be considered during viral reactivation leading to viremia and during GB-based vaccine administration.

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Preeclampsia: A Multifactorial Disease Resulting from the Interaction of the Feto‐maternal HLA Genotype and HCMV Infection

Abstract: The results suggest that the presence of alleles HLA-G0104, DRB107/06, HCMV sequences and the fetal inheritance of maternal G*0104, should be considered as conditioning factors for the development of preeclampsia.

Cited by 51 publications

References 40 publications

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

A critical look at HLA-G

Impact of Local Endothelial Challenge with Cytomegalovirus or Glycoprotein B on Vasodilation in Intact Pressurized Arteries from Nonpregnant and Pregnant Mice1

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Preeclampsia: A Multifactorial Disease Resulting from the Interaction of the Feto‐maternal HLA Genotype and HCMV Infection

Abstract: The results suggest that the presence of alleles HLA-G*0104, DRB1*07/06, HCMV sequences and the fetal inheritance of maternal G*0104, should be considered as conditioning factors for the development of preeclampsia.

Cited by 51 publications

References 40 publications

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

A critical look at HLA-G

Impact of Local Endothelial Challenge with Cytomegalovirus or Glycoprotein B on Vasodilation in Intact Pressurized Arteries from Nonpregnant and Pregnant Mice1

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Product

Resources

About

Abstract: The results suggest that the presence of alleles HLA-G0104, DRB107/06, HCMV sequences and the fetal inheritance of maternal G*0104, should be considered as conditioning factors for the development of preeclampsia.