Predominance of Trichophyton interdigitale Revealed in Podiatric Nail Dust Collections in Eastern Australia

Hainsworth, Steven; Hubka, Vít; Lawrie, A. C.; Carter, Dee; Vanniasinkam, Thiru; Grando, Danilla

doi:10.1007/s11046-019-00363-6

Cited by 7 publications

(10 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the correlation between the genotype and the clinical manifestation or source of isolates has been repeatedly demonstrated, the correlation between ITS genotype and phenotype is relatively poor (Heidemann et al 2010, Pchelin et al 2016, Dhib et al 2017. Currently, the molecular diagnosis of these species is mostly based on several unique sites in the ITS region, and phylogenies usually resolve T. mentagrophytes as para-or polyphyletic with T. interdigitale (Heidemann et al 2010, Nenoff et al 2019, Singh et al 2019, Taghipour et al 2019, Hainsworth et al 2020.…”

Section: Species Delimitation Issues In Trichophytonmentioning

confidence: 99%

Resolving the taxonomy of emerging zoonotic pathogens in the Trichophyton benhamiae complex

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Species Delimitation Issues In Trichophytonmentioning

confidence: 99%

Resolving the taxonomy of emerging zoonotic pathogens in the Trichophyton benhamiae complex

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…in Arizona in animal burrows in geographic locations with reported high or low incidence of human disease. Hainsworth and colleagues describe a unique surveillance approach for the toenail dermatophytes from Australia [25]. The authors collected nail dust bags from podiatric physicians' offices from four different geographic areas.…”

mentioning

confidence: 99%

Onygenalean Fungi as Major Human and Animal Pathogens

Chaturvedi

Hoog

2020

Mycopathologia

View full text Add to dashboard Cite

During the last two decades, many onygenalean pathogens were discovered, redefined, or reclassified from existing taxa into clusters of microspecies, among which the original genotypes often appeared to be uncommon and exceptional. The impact of these developments on the diagnosis and treatment of fungal diseases remains to be determined in most instances. This exciting collection of invited articles provides a full flavor of ongoing changes in the knowledge about taxonomy, genetics, ecology, epidemiology, and clinical spectra of human and animal pathogens classified in the order Onygenales. Recent developments have set the stage for an ambitious translational research agenda. Diagnostic mycology laboratories now need MALDI-TOF-MS spectra, PCR probes, and other specific tools to assist them in the rapid diagnosis of new species. Similarly, an educational set of type materials of new species needs to be readily available for enhanced expertise among the wider medical mycology community. As several new species were discovered retrospectively, it is crucial to expand the re-sampling to other fungal culture collections and archived paraffin tissues. Finally, clinical and laboratory investigations are needed to get an accurate assessment of the prevalence and impact of new pathogens as the cause of major fungal diseases.

show abstract

“…This fact also diminishes the importance of ITS region genotyping in the T. mentagrophytes lineage, which is increasingly used to characterize isolates of the T. mentagrophytes complex. 3 , 16 , 25 , 47 It is unlikely that particular ITS genotypes of the T. mentagrophytes lineage will exhibit significantly different and stable biological features in the long term, as the differences between strains are diminished by recombination between sublineages. From a practical point of view, it may be appropriate to recognize ITS genotypes representing T. interdigitale and ITS genotype VIII of T. mentagrophytes ( T. indotineae ), which are associated either with a specific clinical manifestation or a more frequent occurrence of resistance.…”

Section: Discussionmentioning

confidence: 99%

Defining the relationship between phylogeny, clinical manifestation, and phenotype for Trichophyton mentagrophytes/interdigitale complex; a literature review and taxonomic recommendations

et al. 2023

View full text Add to dashboard Cite

This study looked for correlations between molecular identification, clinical manifestation and morphology for Trichophyton interdigitale and T. mentagrophytes. For this purpose, a total of 110 isolates were obtained from Czech patients with various clinical manifestations of dermatophytosis. Phenotypic characters were analysed, and the strains were characterized using multilocus sequence typing. Among the 12 measured/scored phenotypic features, statistically significant differences between species were found only in growth rates at 37°C and in the production of spiral hyphae. Correlations were found between T. interdigitale and higher age of patients and between clinical manifestations such as tinea pedis or onychomychosis. In addition, the T. interdigitale lineage consisted exclusively of isolates with MAT1-2-1 mating type gene idiomorphs. The MLST approach showed that ITS genotyping of T. mentagrophytes isolates has limited practical benefits because of extensive gene flow between sublineages. Based on our results and previous studies, there are few taxonomic arguments for preserving both species names. The species show a lack of monophyly and unique morphology. On the other hand, some genotypes are associated with predominant clinical manifestations and sources of infections, which keep those names alive. This practice is questionable because the use of both names confuses identification, leading to difficulty in comparing epidemiological studies. The current identification method using ITS genotyping is ambiguous for some isolates and is not user-friendly. Additionally, identification tools such as MALDI-TOF MS fail to distinguish these species. To avoid further confusion and simplify identification in practice, we recommend using the name T. mentagrophytes for the entire complex. When clear differentiation of populations corresponding to T. interdigitale and T. indotineae is possible based on molecular data, we recommend optionally using a variety rank: T. mentagrophytes var. interdigitale and T. mentagrophytes var. indotineae.

show abstract

Predominance of Trichophyton interdigitale Revealed in Podiatric Nail Dust Collections in Eastern Australia

Cited by 7 publications

References 37 publications

Resolving the taxonomy of emerging zoonotic pathogens in the Trichophyton benhamiae complex

Resolving the taxonomy of emerging zoonotic pathogens in the Trichophyton benhamiae complex

Onygenalean Fungi as Major Human and Animal Pathogens

Defining the relationship between phylogeny, clinical manifestation, and phenotype for Trichophyton mentagrophytes/interdigitale complex; a literature review and taxonomic recommendations

Contact Info

Product

Resources

About