Resolving the taxonomy of emerging zoonotic pathogens in the Trichophyton benhamiae complex

Čmoková, Adéla; Kolařík, Miroslav; Dobiáš, Radim; Hoyer, Lois L.; Janouškovcová, Helena; Kano, Rui; Kuklová, Ivana; Lysková, Pavlína; Machová, Lenka; Maier, Τ.; Mallátová, Naďa; Man, Matěj; Mencl, Karel; Nenoff, P.; Peano, Andrea; Prausová, Hana; Stubbe, Dirk; Uhrlaß, Silke; Větrovský, Tomáš; Wiegand, Cornelia; Hubka, Vít

doi:10.1007/s13225-020-00465-3

Cited by 36 publications

(99 citation statements)

References 182 publications

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“…At the base of the phylogenetic tree, the strains known to be of the 'African race' are clustered together in a well-supported monophyletic sister clade of T. bullosum. This result supports the notion that the 'African race' of T. benhamiae should be considered a separate species, the recently described T. africanum [15].…”

Section: T Africanum Lineagesupporting

confidence: 89%

“…Within these lineages, most species were well defined and supported with high bootstrap values, although delineation of the recently introduced species T. europaeum and T. japonicum proved difficult using these markers (Figure 1). T. europaeum and T. japonicum have been shown to be more easily separated phylogenetically when using microsatellite markers and the Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) gene [15]. While BT did not differ between these two species, ITS showed one informative SNP and can thus be used as a barcoding sequence.…”

Section: Discussionmentioning

confidence: 99%

“…Takashio (1974) later observed the existence of two separate races within T. benhamiae, an 'Americo-European' race and an 'African' race, through the use of mating experiments and phenotypic analysis [14]. Molecular data has shown that these races are quite genetically distant from each other and that they are not monophyletic.Čmoková et al recently proposed the name T. africanum to cement the African race of T. benhamiae as a separate species, together with two other new species within the T. benhamiae species complex: T. europaeum and T. japonicum [15]. Within the 'Americo-European' race, two phenotypic variants can be distinguished: the white and the yellow phenotype.…”

Section: Introductionmentioning

confidence: 99%

“…While the white phenotype has been around since the species was first described, the yellow variant was only first discovered in 2008 [16]. Genetically, these phenotypic variants seem to be indistinguishable [5,8,15]. In the last few decades, T. benhamiae has also become a more prevalent agent of dermatophyte infection in several European regions [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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A Polyphasic Approach to Classification and Identification of Species within the Trichophyton benhamiae Complex

Baert

Lefevere

D’hooge

et al. 2021

JoF

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In recent years, considerable advances have been made in clearing up the phylogenetic relationships within the Arthrodermataceae family. However, certain closely related taxa still contain poorly resolved species boundaries. Here, we tried to elucidate the species composition of the Trichophyton benhamiae species complex using a combined approach consisting of multi-gene phylogenetic analysis based on internal transcribed spacer (ITS) and beta-tubulin (BT) gene regions, morphological analysis, and spectral comparison using MALDI-ToF. We confirmed the existence of 11 different monophyletic clades within the complex representing either species or genetically distinct groups within species. MALDI-ToF spectrometry analysis revealed that most of these clades were readily distinguishable from one another; however, some closely related sister clades, such as T. europaeum and T. japonicum, were often misidentified as their counterpart. The distinct “yellow” and “white” phenotypes of T. benhamiae do not have a clear genetic basis and should thus be considered as different morphotypes of the same species. Strains traditionally considered T. benhamiae can be divided into three main clades: (i) T. benhamiae, (ii) T. europaeum/T. japonicum, and (iii) the phylogenetically distant T. africanum. While T. europaeum and T. japonicum are distinguishable based on their genotype, spectral and morphological analysis did not provide clear delimiting characteristics.

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Section: T Africanum Lineagesupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Polyphasic Approach to Classification and Identification of Species within the Trichophyton benhamiae Complex

Baert

Lefevere

D’hooge

et al. 2021

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“…Trichophyton erinacei is a zoophilic dermatophyte transmitted from hedgehogs; it belongs to the T. benhamiae complex, along with eight other zoo- and anthropophilic pathogens [ 1 ]. Infection usually occurs by direct contact with an infected hedgehog, although indirect contact with contaminated material such as their nests has also been described [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Detection and Control of Dermatophytosis in Wild European Hedgehogs (Erinaceus europaeus) Admitted to a French Wildlife Rehabilitation Centre

Barzic

Čmoková

Denaes

et al. 2021

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The rising number of European hedgehogs (Erinaceus europaeus) admitted every year to wildlife rehabilitation centres might be a source of concern to animal and public health since transmissible diseases, such as dermatophytosis, can be easily disseminated. This study seeks to evaluate the frequency of dermatophyte detection in hedgehogs admitted to a wildlife rehabilitation centre located near Paris, France, and to assess the risk of contamination in the centre in order to adapt prevention measures. A longitudinal cohort study was performed on 412 hedgehogs hosted at the Wildlife Animal Hospital of the Veterinary College of Alfort from January to December 2016. Animals were sampled once a month for fungal culture. Dermatophyte colonies were obtained from 174 out of 686 skin samples (25.4%). Besides Trichophyton erinacei, Trichophyton mentagrophytes and Nannizzia gypsea were also found. Dermatophyte detection seemed to be associated with the presence of skin lesions, while more than one-third of T. erinacei-positive animals were asymptomatic carriers. Healing required several months of treatment with topical and systemic azoles, but dermatophytosis did not seem to reduce the probability of release. Daily disinfection procedures and early detection and treatment of infected and asymptomatic carriers succeeded in limiting dermatophyte transmission between hedgehogs and humans.

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Molecular Taxonomy

Hagen,

Walther,

Houbraken

et al. 2023

Diagnosis and Treatment of Fungal Infections

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Resolving the taxonomy of emerging zoonotic pathogens in the Trichophyton benhamiae complex

Abstract: Resolving the taxonomy of emerging zoonotic pathogens in the Trichophyton benhamiae complex

Cited by 36 publications

References 182 publications

A Polyphasic Approach to Classification and Identification of Species within the Trichophyton benhamiae Complex

A Polyphasic Approach to Classification and Identification of Species within the Trichophyton benhamiae Complex

Detection and Control of Dermatophytosis in Wild European Hedgehogs (Erinaceus europaeus) Admitted to a French Wildlife Rehabilitation Centre

Molecular Taxonomy

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