Predominance of multi-drug-resistant LAM and Beijing family strains among Mycobacterium tuberculosis isolates recovered from prison inmates in Tula Region, Russia

Abstract

The genotypic characteristics and drug susceptibility profiles of clinical isolates of Mycobacterium tuberculosis recovered from prison hospital patients in the Tula region (central Russia) during 2001 and 2002 are reported. The emergence of multi-drug-resistant tuberculosis (TB) poses a major health risk to the population, with economic implications for TB control. Prisons serve as a continuous source of TB transmission. The results showed that members of the LAM and Beijing families are major contributors to the epidemiological picture of TB in the population studied. The two families of strains accounted for most of the drug-resistant TB in the population. The genotypic characteristics of the M. tuberculosis predominant LAM strain that was responsible for 31 % of TB cases in this setting are presented.

Extremely high prevalence of multidrug resistant tuberculosis in Murmansk, Russia: a population-based study

“…This is consistent with the observation that unusually high proportion of Ser315Thr mutation is characteristic of INH-resistant strains in Russia [31][32][33]. As previously reported, mutations in codons 531, 526 and 516 of rpoB are responsible for 86-100% of RIF-resistant TB cases in Russia in agreement with other global reports originating from regions with high rates of MDR-TB [34].…”

“…Likewise, this mutation is has not been reported in the TB Drug Resistance Database (http://www.tbdreamdb.com/RIF_Rv0667_AllMutations.html). The absence of SNPs within the RRDR has been reported in approximately 10% of MDR cases in other studies [33,38] indicating that other resistance mechanisms are also involved and should be studied. Two isolates presented with multiple mutations in rpoB.…”

Characteristics of drug-resistant tuberculosis in Abkhazia (Georgia), a high-prevalence area in Eastern Europe

“…In most limited-resource countries, MDR-TB cases are identified when patients fail to respond to first-line TB therapy. 4 Prolonged periods of sputum smear positivity might then result in enhanced transmission of MDR strains, further accelerating the increase of MDR-TB incidence. 4 Consequently in countries with high prevalence of resistance, in addition to standard short-course chemotherapy, rapid diagnosis of resistance and appropriate treatment regimens are key components for the control of TB.…”

“…[1][2][3][4] Globally, some of these countries show the highest frequency of isolation of Mycobacterium tuberculosis complex (MTBC) strains of multidrug-resistant (MDR)-TB, defined as resistance to at least isoniazid and rifampicin. MDR-TB rates of up to 14% have been documented, making successful treatment of the disease difficult.…”

Does tuberculosis have a seasonal pattern among migrant population entering Iran?

“…It affects various organs and is spread from person to person through respiration (1,2). This disease can happen following a new infection with Mycobacterium TB or activation of latent TB infection; most cases in endemic countries are due to the transmission of new infection (3)(4)(5).…”