Predominance of enterovirus B and echovirus 30 as cause of viral meningitis in a UK population

Abstract

This study showed a continued predominance of echovirus 30 as a cause of viral meningitis, particularly in adults, though more surveillance is needed.

Nearly Complete Genome Sequence of an Echovirus 30 Strain from a Cluster of Aseptic Meningitis Cases in California, September 2017

“…Fifteen of 19 (79%) EV-positive patients were confirmed to have echovirus 30 (E-30), using cerebrospinal fluid (CSF) samples. This cluster of E-30 meningitis cases is similar to previously reported E-30 aseptic meningitis cases (5,6) in symptoms and epidemiology.…”

Molecular identification of human enteroviruses associated with aseptic meningitis in Yunnan province, Southwest China

“…It is very important to continue surveillance of aseptic meningitis agents in children in order to effectively develop the related vaccines, particularly E-30, which was the most commonly reported serotype (Trallero et al 2010; Holmes et al 2016). At present, although EV-A71 and CV-A16 vaccines have been developed, the development of a broadly protective multivalent vaccine against aseptic meningitis or HFMD should include other predominant serotypes of EVs surveyed by years.…”

Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B

“…The Enterovirus B (EV-B) group consists of echovirus, coxsackievirus B (CV-B), coxsackievirus A9 (CV-A9), and other newly identified enteroviruses (Marjomä ki et al, 2015). EV-B infections cause viral encephalitis (VE), viral meningitis (VM), and viral meningo-encephalitis (VME), leading to substantial morbidity and mortality in children (Holmes et al, 2016;Khetsuriani et al, 2006). They are also the causative agents of acute flaccid paralysis (AFP), nonspecific rashes, pneumonitis, hepatitis, coagulopathy, and hand-foot-and-mouth disease (HFMD) (Abzug, 2014;Huang et al, 2015).…”