Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B

Zhao, Xin; Zhang, Guigen; Liu, Sheng; Chen, Xiangpeng; Peng, Ruchao; Dai, Lianpan; Qu, Xiao; Li, Shihua; Song, Hao; Gao, Zhengrong; Yuan, Peng; Liu, Zhiheng; Li, Changyao; Shang, Zifang; Li, Yan; Zhang, Meifan; Qi, Jianxun; Wang, Han; Du, Ning; Wu, Yan; Bi, Yang; Gao, Shan; Shi, Yi; Yan, Jinghua; Zhang, Yong; Xie, Zhengde; Wei, Wensheng; Gao, George F.

doi:10.1016/j.cell.2019.04.035

Cited by 72 publications

(135 citation statements)

References 77 publications

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“…Indeed HFMD viruses can be divided into four groups depending on their receptor usage ( Supplementary Fig. 1): EV-A71, CV-A7, CV-A14 and CV-A16 use SCARB2 (scavenger receptor class B member 2, also named lysosomal integral membrane protein-2, LIMP-2) 15,16 , Coxsackie viruses A2-6, A8, A10 and A12 use KREMEN1 (kringle (KR) containing transmembrane protein 1; KRM1) 17 , Coxsackie viruses B1-3 and B5 use CAR (Coxsackievirus and adenovirus receptor) and EV-E3, E6, E7, E11 and E12 use DAF/FcRn (decayaccelerating factor/neonatal Fc receptor) 2,18,19 .…”

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confidence: 99%

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

et al. 2020

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Coxsackievirus A10 (CV-A10) is responsible for an escalating number of severe infections in children, but no prophylactics or therapeutics are currently available. KREMEN1 (KRM1) is the entry receptor for the largest receptor-group of hand-foot-and-mouth disease causing viruses, which includes CV-A10. We report here structures of CV-A10 mature virus alone and in complex with KRM1 as well as of the CV-A10 A-particle. The receptor spans the viral canyon with a large footprint on the virus surface. The footprint has some overlap with that seen for the neonatal Fc receptor complexed with enterovirus E6 but is larger and distinct from that of another enterovirus receptor SCARB2. Reduced occupancy of a particle-stabilising pocket factor in the complexed virus and the presence of both unbound and expanded virus particles suggests receptor binding initiates a cascade of conformational changes that produces expanded particles primed for viral uncoating.

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confidence: 99%

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

et al. 2020

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“…Highthroughput approaches now provide alternative, potentially faster methods for host receptor discovery, and have been used to identify numerous receptors within recent years (Table 1). In particular, genetic knockout screening has grown in popularity, leading to the discovery of several bona fide new receptors since 2017, including: NRP2 for Lujo Virus, protocadherin for Andes virus and Sin Nombre virus, kremen1 for multiple human-type A enteroviruses, neonatal Fc receptor for enterovirus B, and human leukocyte antigen DR isotype for bat influenza viruses [67,68,[72][73][74].…”

Section: Discussionmentioning

confidence: 99%

Advances in high-throughput methods for the identification of virus receptors

Barrass

Butcher

2019

Med Microbiol Immunol

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Viruses have evolved many mechanisms to invade host cells and establish successful infections. The interaction between viral attachment proteins and host cell receptors is the first and decisive step in establishing such infections, initiating virus entry into the host cells. Therefore, the identification of host receptors is fundamental in understanding pathogenesis and tissue tropism. Furthermore, receptor identification can inform the development of antivirals, vaccines, and diagnostic technologies, which have a substantial impact on human health. Nevertheless, due to the complex nature of virus entry, the redundancy in receptor usage, and the limitations in current identification methods, many host receptors remain elusive. Recent advances in targeted gene perturbation, high-throughput screening, and mass spectrometry have facilitated the discovery of virus receptors in recent years. In this review, we compare the current methods used within the field to identify virus receptors, focussing on genomic-and interactome-based approaches.

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“…We just noticed that your team, collaborated with other two teams published a paper entitled “Human neonatal Fc receptor is the cellular uncoating receptor for enterovirus B” in Cell . This research is very important for understanding the mechanisms of pathogenesis of enterovirus and new drug development.…”

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confidence: 99%

“…I would like to thanks the PI editor for his thoughtful insight into our work . Enterovirus species B (EV‐B) belongs to the Enterovirus genus of the Picornaviridae family, and includes echovirus, Coxsackie B, Coxsackie A9, and a number of newly discovered EV‐B serotypes.…”

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confidence: 99%