Preditores de mortalidade em pacientes submetidos à nefrectomia por carcinoma de células renais não metastático em um centro de referência no Nordeste Brasileiro

Abstract

. Renal carcinoma is considered the most lethal of urological neoplasms 3 .Its incidence is continually increasing worldwide. In the United States, for example, the incidence of new cases rose from ten to 15 cases per 100,000 inhabitants per year in the last 20 years 4 . In Brazil, the described incidence -considering the high rates of national underreporting -varies from seven to ten cases per 100,000 inhabitants per year in more developed areas, with lower rates in less developed regions 5 . According to the first National Study on Kidney Cancer in Brazil, the disease is more common in men (59%) and Caucasians (79%), with a mean age of 59 years 6 .The clear cell variant is the most common subtype, accounting for 75% of renal cell carcinomas (RCC). Based on morphological, histochemical and cytogenetic aspects, renal carcinoma does not constitute a single neoplasm, but a group comprising four main tumor subtypes: clear cells, papillary type I, papillary type II and chromophobe, with incidence of 75%, 5%, 10% and 5%, respectively. Among these, clear-cell RCC is the one that displays the most aggressive behavior 7 .There is great heterogeneity in renal cancer regarding both age, histological subtype, degree of differentiation or staging. This fact justifies the great clinical importance of this disease and the search for knowledge for a better clinical and surgical approach. About 75% of renal cancer cases occur in individuals

Incidence and mortality rates of kidney cancers in Iran compared to its proportion throughout the world

“…Every selected drug has to be optimized in terms of its dose and schedule (53). It should be mentioned that for nephrectomy candidates with non-metastatic RCC, pathological stage and lymph node involvement could be very important prognostic factors (54). Moreover, RCC may have an unpredictable time course, with recurrence intervals of even up to 30 years, Therefore, prolonged periods of follow-up may be necessary for these patients (55).…”

Análise dos pacientes com Câncer Renal no Hospital Geral de Fortaleza no período de 2017 a 2022

“…Epidemiologicamente, o Brasil apresenta um sub-registro dos dados referentes à incidência do câncer de rim, com estimativas que variam de 7 a 10 casos por 100.000 habitantes/ano. A doença é mais comum em homens (59%) e na raça branca (79%), com idade média de 59 anos 5 . Segundo o Instituto Nacional do Câncer, em 2020, o Brasil registrou 3,630 Brazilian Journal of Health Review, Curitiba, v. 6, n. 4, p. 17681-17694, jul./aug., 2023 mortes por câncer renal, com uma taxa de mortalidade de 1,89 para homens e 0,94 para mulheres.…”