Prédisposition aux infections des malades ayant un pemphigus

Belgnaoui, F.; Senouci, Karima; Chraibi, Hamza; Aoussar, A.; Mansouri, F.; Benzekri, Laïla; Ourhroui, Mohamed Ait; Abouqal, Rédouane; Heid, E; Hassam, Badredine

doi:10.1016/j.lpm.2006.12.034

Cited by 20 publications

(18 citation statements)

References 21 publications

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“…Our study also found the LOS prolonged in inpatients with BSIs (p = 0.008). Ninetyfour (49.2%, 87/177) inpatients with pemphigus developed BSIs in our research, parallel with another study (52%, 73/141) [16]. S. aureus was the most common type of bacteria [10,[17][18][19].…”

Section: Discussion/conclusionsupporting

confidence: 82%

“…Associated factors for BSIs were explored. Hsu et al suggested that patients who had multi-morbidities and poor health conditions were more likely to develop lethal infections [15], and DM was associated with infections in many studies [1,16,17,20]. However, comorbidities, such as DM, CVD, CHD, etc., were not signi cantly associated with BSIs in our study.…”

Section: Discussion/conclusionmentioning

confidence: 99%

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Features and Associated Factors of Bacterial Skin Infections in Hospitalized Patients with Pemphigus: A Single-Center Retrospective Study

Bian

et al. 2020

Preprint

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Background: Infections were the primary cause of death (34.3%-55.5%) in patients with pemphigus. Skin was usually the origin of infections. The study aimed to explore features and associated factors of bacterial skin infections (BSIs) in inpatients with pemphigus. Methods: One hundred and eighty-four inpatients with pemphigus visiting the dermatology department of Peking University First hospital during 2013 to 2019 were continuously recruited to study the characteristics and associated factors of BSIs.Results: Of patients enrolled, pemphigus vulgaris (PV, n=142) and pemphigus foliaceus (PF, n=9) were most common, followed by pemphigus erythematosus (PE, n=25) and pemphigus vegetans (Pveg, n=1). Eighty-seven of 177 (49.2%) inpatients developed BSIs, and they had a longer length of stay compared with inpatients without BSIs (median: 18.9 days vs. 14.1 days, p = 0.008). Staphylococcus aureus was the most common bacteria and highly resistant to penicillin (91.9%). Higher levels of anti-Dsg1 autoantibodies (>124.2U/mL) (p<0.001, odds ratio [OR]=3.564, 95% confidence interval [CI]: 1.784-7.123) and anti-Dsg3 autoantibodies (>169.5U/mL) (p = 0.03, OR=1.074, 95% CI: 1.084-3.969) were underlying risk factors of BSIs. As for Gram’s stain of bacteria, females had a lower rate of Gram-positive infections (p = 0.03). Patients systematically using of antibiotics (p = 0.05) had a higher rate of Gram-negative infections. Inpatients with history of hospitalization had a higher rate of Gram-negative and co-infections (p = 0.03). Conclusions: Inpatients with pemphigus had a high incidence rate of BSIs. High levels of anti-Dsg1 (>124.2U/mL) and Dsg3 autoantibodies (>169.5U/mL) might be underlying risk factors for BSIs.

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Section: Discussion/conclusionsupporting

confidence: 82%

Section: Discussion/conclusionmentioning

confidence: 99%

Features and Associated Factors of Bacterial Skin Infections in Hospitalized Patients with Pemphigus: A Single-Center Retrospective Study

Bian

et al. 2020

Preprint

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“…On the other hand, hospitalization in addition to immunosuppressive therapy would predispose the PV patients to infection. In some studies bacterial infections have been reported [ 20 , 21 ]. Most bacterial skin infections detected in our patients were due to Staphylococcus aureus .…”

Section: Discussionmentioning

confidence: 99%

The Prevalence ofS. aureusSkin and Soft Tissue Infections in Patients with Pemphigus

Aghmiyuni

Kazemi

Moniri

et al. 2016

Autoimmune Diseases

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Pemphigus vulgaris are autoimmune blistering diseases that may result in significant morbidity and death. Immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. The aim of this study was to assess the prevalence of S. aureus infection and PVL gene in patients with pemphigus admitted to dermatology clinic. Materials and Methods. This descriptive study was conducted on 196 pemphigus vulgaris patients (119 males, 77 females) admitted to dermatology clinic between 2014 and 2015. In this study, the diagnosis of pemphigus vulgaris was made by histology, immunofluorescence pattern of perilesional skin, and indirect immunofluorescence testing of serum. Data were collected through a questionnaire. Results. 59.1% of pemphigus vulgaris patients had S. aureus infection. 49 out of 116 were methicillin-resistant. PVL gene was detected in 25 out of 116 S. aureus positive patients. Conclusion. This is the first report of S. aureus infection in pemphigus patients in Iran. More than forty percent of isolates were methicillin-resistant S. aureus. PVL gene carried by methicillin-resistant S. aureus was high in this study.

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“…Les dermatoses bulleuses étaient dominées par le pemphigus, fréquent dans notre pays et nécessitant un séjour prolongé du fait de la difficulté thérapeutique et des complications infectieuses et iatrogènes [18,19]. …”

Section: Discussionunclassified

Bilan d'hospitalisation du service de dermatologie-v&#233n&3233rologie du CHU Ibn Sina Rabat Maroc

Lamchahab¹,

Beqqal²,

Guerrouj³

et al. 2011

Pan Afr Med Jrnl

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Introduction Le service de Dermatologie de l’Hôpital Ibn Sina a pour mission de donner les soins en matière de dermatologie et concourt au service public de la santé au Maroc. Le but de ce travail est d’établir le profil épidémiologique et diagnostique des dermatoses en milieu hospitalier à travers cinq ans d’activité d’hospitalisation. Méthodes Etude rétrospective menée sur une période de cinq ans de janvier 2003 à janvier 2008 concernant tous les patients hospitalisés au service de dermatologie. Résultats 2033 patients avaient été hospitalisés pendant la période étudiée. L’âge moyen était de 40 ans. Les patients provenaient surtout de la région Rabat – Salé – Zaër. Chez l’adulte, les pathologies les plus fréquemment rencontrées étaient les maladies de système et les pathologies infectieuses. Le taux de mortalité était très faible. Les dermatoses du milieu hospitalier sont diverses. Les maladies de système occupent le premier rang. Ceci peut être justifié par la multitude des bilans nécessaires. Les dermatoses bulleuses nécessitent une longue prise en charge et sont à l’origine des séjours prolongés des patients. Conclusion Les affections cutanées constituent une source majeure de morbidité. Les formes graves nécessitent une prise en charge adéquate.

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Prédisposition aux infections des malades ayant un pemphigus

Cited by 20 publications

References 21 publications

Features and Associated Factors of Bacterial Skin Infections in Hospitalized Patients with Pemphigus: A Single-Center Retrospective Study

Features and Associated Factors of Bacterial Skin Infections in Hospitalized Patients with Pemphigus: A Single-Center Retrospective Study

The Prevalence ofS. aureusSkin and Soft Tissue Infections in Patients with Pemphigus

Bilan d'hospitalisation du service de dermatologie-v&#233n&3233rologie du CHU Ibn Sina Rabat Maroc

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