Predisposing Factors, Neurological Complications and Sequels of Guillain Barre Syndrome at Discharge: Experience in an Icu of a Third Level Hospital

Rodríguez, E.; Vega, Adolfo Rodríguez de la; Arlanzón, R Vara; Barrio, E Martínez; Ortiz, María del Valle; Ratero, JA Fernández; Rodríguez, ME Perea; Escapa, M Gero; Baladía, M Montero; Simal, Sara Calvo

doi:10.1186/2197-425x-3-s1-a993

Cited by 2 publications

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“…Both subjects were hypotensive and were given fluids and vasopressors but the hypotension was not treated so the patient fell into cardiac arrest. A study conducted in Australia stated that the mortality of GBS patients was greater in patients who used mechanical ventilation and had a high APACHE score (Portugal Rodríguez et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Therapeutic Plasma Exchange Procedures in Patients with Myasthenia Gravis and Guillain Barre Syndrome and their Outcomes during Hospitalization in General Intensive Care Unit Hasan Sadikin General Hospital Bandung in January 2017 to December 2020

Maskoen¹,

Inggriani²,

Erlangga³

2022

jhms

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Background: Myasthenia Gravis and Guillain-Barré syndrome are two of the most common autoimmune diseases affecting the peripheral nervous system in the world. Both of the diseases manifested as progressive muscle weakness, areflexia, and inspiratory muscle weakness which leads to mechanical ventilation support. Therapeutic Plasma Exchange is the first line of treatment according to the American Society for Apheresis (AFSA), which is a relatively safe and often performed procedure In the Intensive Care Unit (ICU), including in Hasan Sadikin Hospital Bandung (RSHS). Purpose: The goal of this study is to obtain the background characteristics of MG and GBS patients and to obtain the outcome of TPE in these patients. Methods: The study was a descriptive study performed on 30 MG and GBS patients who received TPE in the Intensive care unit, RSHS from January 2017 to December 2020. Data for the study was obtained retrospectively from the patient medical record. Results: The result showed that the most common side effect during TPE was electrolyte imbalance. There was no reported morbidity and mortality in MG patients, in contrast to two mortality cases in GBS patients. Length of stay in the intensive care unit was influenced by several factors including age, comorbidities, the severity of MG, and morbidities that occurred during the hospital stay. Conclusion: Outcome of MG and GBS patients with TPE procedure is good in relation with low TPE-unrelated morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Therapeutic Plasma Exchange Procedures in Patients with Myasthenia Gravis and Guillain Barre Syndrome and their Outcomes during Hospitalization in General Intensive Care Unit Hasan Sadikin General Hospital Bandung in January 2017 to December 2020

Maskoen¹,

Inggriani²,

Erlangga³

2022

jhms

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“…23 Penelitian yang dilakukan di Australia menyatakan bahwa mortalitas pasien SGB lebih besar terjadi pada pasien yang menggunakan ventilasi mekanik dan memiliki nilai skoring APACHE yang lebih tinggi. 26 Pada penelitian Van Den Berg, komplikasi respiratori seperti pneumonia atau dengan komorbid kegagalan napas akibat infeksi paru akan membutuhkan penggunaan ventilasi mekanik yang berkepanjangan dan menjadi penyebab kematian terbesar pada pasien SGB yang menjalani terapi plasmaferesis, dimana dari 50 orang, 12 orang penderita SGB yang menjalani plasmaferesis meninggal dunia akibat pneumonia dan sepsis. 25,27 Pada penelitian tersebut juga ditemukan sebanyak 8 pasien mengalami pneumonia dan 30 pasien menggunakan mesin ventilator >14 hari dengan rata-rata bergantung ventilasi mekanik >20 hari dan mengalami mortalitas.…”

Section: Pembahasanunclassified

Analisis Terhadap Faktor Risiko yang Berhubungan dengan Mortalitas Pasien Sindrom Guillain-Barré yang Dilakukan Plasmaferesis

Bangun,

Sudjud,

Zulfariansyah

2023

JAI b

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Latar Belakang: Sindrom Guillain-Barré (SGB) merupakan penyakit autoimun yang mengenai sistem saraf tepi yang banyak ditemukan di dunia. Penyakit ini memiliki manifestasi berupa kelemahan, arefleksia otot secara progresif dan dapat menyebabkan kelemahan pada otot-otot pernapasan. Hal ini menyebabkan penderita membutuhkan bantuan ventilasi mekanik. American Society for Apheresis (ASFA) menyatakan pengobatan lini pertama krisis sindrom Guillain-Barré (SGB) fase akut adalah dengan pemberian therapeutic plasma exchange/plasmaferesis. Therapeutic plasma exchange merupakan prosedur yang relatif aman dan sudah sering dilakukan di unit rawat intensif Rumah Sakit Hasan Sadikin (RSHS) Bandung.Tujuan: Penelitian ini dilakukan untuk menganalisis faktor-faktor risiko yang berhubungan dengan mortalitas pasien SGB yang telah menjalani terapi plasmaferesis.Metode: Penelitian ini merupakan penelitian analitik multivariat dengan desain kasus kontrol yang dilakukan pada 55 sampel pasien SGB yang mendapatkan terapi plasmaferesis di unit rawat intensif RSHS Bandung dan rumah sakit (RS) Bhayangkara Tingkat II Medan. Penelitian ini bersifat retrospektif dengan mengambil data dari rekam medis serta menyajikan karakteristik dasar subjek.Hasil: Penelitian ini mendapatkan hasil bahwa diantara faktor-faktor risiko yaitu usia, komorbid, dan lama penggunaan ventilasi mekanik, yang paling berhubungan dengan mortalitas pasien SGB yang telah menjalani terapi plasmaferesis adalah faktor lamanya penggunaan ventilasi mekanik >14 hari.Kesimpulan: Faktor risiko penggunaan mesin ventilasi mekanik berkepanjangan (>14 hari) berhubungan dengan tingginya kejadian mortalitas/kematian pada pasien SGB yang menjalani terapi di RSHS Bandung, maupun di RS Bhayangkara Tingkat II Medan.

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Predisposing Factors, Neurological Complications and Sequels of Guillain Barre Syndrome at Discharge: Experience in an Icu of a Third Level Hospital

Cited by 2 publications

References 0 publications

Characteristics of Therapeutic Plasma Exchange Procedures in Patients with Myasthenia Gravis and Guillain Barre Syndrome and their Outcomes during Hospitalization in General Intensive Care Unit Hasan Sadikin General Hospital Bandung in January 2017 to December 2020

Characteristics of Therapeutic Plasma Exchange Procedures in Patients with Myasthenia Gravis and Guillain Barre Syndrome and their Outcomes during Hospitalization in General Intensive Care Unit Hasan Sadikin General Hospital Bandung in January 2017 to December 2020

Analisis Terhadap Faktor Risiko yang Berhubungan dengan Mortalitas Pasien Sindrom Guillain-Barré yang Dilakukan Plasmaferesis

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