Predictors of vitamin D status in subjects that consume a vitamin D supplement

Levy, Mark A.; McKinnon, Toni; Barker, Tyler; Dern, Adam; Helland, Thomas; Robertson, Julie M.; Cuomo, John; Wood, Tim; Dixon, Brian

doi:10.1038/ejcn.2014.133

Cited by 19 publications

(17 citation statements)

References 64 publications

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“…This is supported by Levy et al who found that BMI was the second largest (and the largest negative) determinant of vitamin D status in persons consuming a vitamin D supplement [20]. Persons with a high BMI generally have a higher content of body fat that may both serve as a storage reservoir but is also extremely slow to release vitamin D [20].…”

Section: Discussionmentioning

confidence: 79%

“…Persons with a high BMI generally have a higher content of body fat that may both serve as a storage reservoir but is also extremely slow to release vitamin D [20]. Low circulating vitamin D levels in obese persons may therefore result from a dilution effect of vitamin D within the large body mass [20].…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the well-known association between season and vitamin D status [15], several lifestyle factors such as obesity, smoking, physical activity, and diet have been found to be predictors of vitamin D status in cross-sectional analyses [16][17][18][19][20][21][22]. Hence, Thuesen et al found that low vitamin D status was significantly associated with obesity, daily smoking, and a sedentary lifestyle [23].…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements

et al. 2015

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Several lifestyle factors have been found to be associated with vitamin D status in cross-sectional studies, but it is not clear whether a change in these factors can actually affect the vitamin D level. We investigated the association between repeated measurements of physical activity, body mass index (BMI), diet, alcohol consumption, and smoking habits, and corresponding levels of vitamin D during 5 years of follow-up of a large general population sample. We included 4185 persons who participated and had vitamin D (serum-25-hydroxyvitamin D, 25-OH-D) measurements in the Inter99 study at baseline (1999-2001) and 5-year follow-up. In a subsample, 25-OH-D was also measured at 1- and 3-year follow-ups. We used mixed models to examine the association between repeated measurements of lifestyle factors and 25-OH-D levels. In multivariable analyses of repeated measurements, the difference in 25-OH-D was -0.32 ng/ml (95 % CI -0.37, -0.28) per 1 kg/m(2) increase in BMI; 4.50 ng/ml (95 % CI 3.84, 5.15) for persons moderately/vigorously physically active versus sedentary; 1.82 ng/ml (95 % CI 1.09, 2.56) for persons with healthy versus unhealthy dietary habits; 0.05 ng/ml (95 % CI 0.03, 0.07) per 1 standard drink/weak increase in alcohol consumption; and 0.86 ng/ml (95 % CI 0.36, 1.35) for never smokers versus daily smokers. Our study shows that lower BMI, a higher level of physical activity, a healthier diet and possibly a higher alcohol intake, and not smoking, are associated with higher 25-OH-D levels.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements

et al. 2015

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“…Vitamin D level of 75 nmol·L –1 may be a more appropriate goal for most people [27, 28]. Among these people, 56.04% had normal levels of vitamin D. The result of ANOVA analysis revealed that there is statistical significant difference between the level of vitamin D among the 3 groups and also demographic and bio-indices: age ( p = 0.008), insulin ( p = 0.028), fat percentage ( p = 0.0002), fat free mass ( p = 0.0003), RMR ( p = 0.08), RMR/kg body weight ( p ≤ 0.0001), RMR/BMI ( p ≤ 0.0001), VDR ( p ≤ 0.0001), and PGC ( p ≤ 0.0001).…”

Section: Resultsmentioning

confidence: 99%

Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults

Sajjadi¹,

Mirzaei

Khorraminezhad

et al. 2017

Ann Nutr Metab

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Background: Resting metabolic rate (RMR) used to prognosticate and measure the amount of energy required. Vitamin D is known as a new predictor of RMR. The aim of this study is to investigate the relationship between vitamin D effects on RMR in connection with the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) gene expression. Methods: We enrolled 298 overweight and obese adults in this cross-sectional study. Body mass index (BMI), fat mass, fat-free mass, insulin level, visceral fat, and vitamin D status were assessed. RMR was measured by means of indirect calorimetry. The real-time polymerase chain reaction using specific primer pairs for VDR and PGC-1α was performed. Results: There were significant differences in terms of fat free mass, fat percentage, insulin levels, RMR/kg body weight, and RMR/BMI, VDR, and PGC-1α among participants were categorized based on the vitamin D status. But after using general linear model for adjusting, all significant results missed their effectiveness except RMR/kg body weight and VDR. Linear regression analysis used to show the mediatory role of VDR and PGC-1α on the RMR/kg body weight and vitamin D status relationship. Our results showed that VDR had a mediatory effect on the relationship between RMR/kg body weight and vitamin D status (β = 0.38, 95% CI –0.48 to 1.60; β = –1.24, 95% CI –5.36 to 1.70). However, PGC-1α did not affect the relationship between RMR/kg body weight and vitamin D status (β = 0.50, 95% CI = –0.02 to 3.42; β = 0.59, 95% CI 0.14–3.90). Conclusion: Our study showed the mediatory effect of VDR gene expression in the association of 25(OH)₂D plasma levels and resting metabolic rate among obese individuals.

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“…A dose of 800 IU of vitamin D achieved levels of 30 ng/mL at 6 and 12 months. Other studies have shown that vitamin D supplements increase vitamin D levels in both summer and winter, with no seasonal differences [28,29,30]. The strength of the study lies in the homogeneity of the study population, the methodological design, and the genistein dose.…”

Section: Discussionmentioning

confidence: 96%

The Effect of Genistein Supplementation on Vitamin D Levels and Bone Turnover Markers during the Summer in Healthy Postmenopausal Women: Role of Genotypes of Isoflavone Metabolism

Pérez-Alonso

Briongos²,

Ruiz-Mambrilla³

et al. 2017

Lifestyle Genomics

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Aims: The objective of this study was to determine whether vitamin D and genistein supplementation had an additive beneficial effect on levels of vitamin D and bone markers and whether this effect was mediated by genes regulating isoflavone metabolism. Materials and Methods: We carried out a prospective study in postmenopausal women randomized to calcium and vitamin D supplementation or calcium, vitamin D, and genistein supplementation. Vitamin D, parathyroid hormone (PTH), cross-linked C-telopeptide (CTX), and procollagen 1 N-terminal (P1NP) were determined by electrochemiluminescence. Three SNPs - rs2231142 (ABCG2), rs358231 (cytosolic β-glucosidase [CBG]), and rs2273697 (ABCC2) - were determined. Results: We included 102 women. The effects on bone remodeling were similar: rises in vitamin D were significantly associated with reductions in PTH, CTX, and P1NP. Pharmacogenomic analysis of the genotypes showed that, in AT heterozygotes of the CBG1368T>A polymorphism, CTX and P1NP were not reduced. Conclusion: Genistein added to calcium and vitamin D supplementation had no additional effect. The supplementation of individual AT heterozygotes of the CBG1368T>A polymorphism had no effect on markers of bone remodeling.

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Predictors of vitamin D status in subjects that consume a vitamin D supplement

Abstract: Vitamin D supplementation was the most significant positive predictor of vitamin D status. Collectively, these data point to the practicality of utilizing vitamin D supplements to reduce hypovitaminosis D in adults throughout the United States.

Cited by 19 publications

References 64 publications

Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements

Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements

Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults

The Effect of Genistein Supplementation on Vitamin D Levels and Bone Turnover Markers during the Summer in Healthy Postmenopausal Women: Role of Genotypes of Isoflavone Metabolism

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