The Effect of Genistein Supplementation on Vitamin D Levels and Bone Turnover Markers during the Summer in Healthy Postmenopausal Women: Role of Genotypes of Isoflavone Metabolism

Pérez-Alonso, María; Briongos, Laisa-Socorro; Ruiz-Mambrilla, Marta; Velasco, Eladio A.; Linares, Lidia Urbón López de; Cuéllar, L; Olmos, José M.; Luis, Daniel Antonio de; Dueñas‐Laita, Antonio; Pérez-Castrillón, José-Luis

doi:10.1159/000484480

Cited by 9 publications

(9 citation statements)

References 27 publications

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“…Lastly, administration of isoflavones or genistein alone for 1 to 24 months did not alter PTH in postmenopausal women [ 78 , 92 , 180 , 181 , 182 , 183 ]. Only a cross-sectional study carried out with Chinese women found that postmenopausal women with a high intake of isoflavone had lower serum PTH levels [ 184 ].…”

Section: Effect Of Phytoestrogen Intake On Hormones Related To Bonmentioning

confidence: 99%

Effects of Dietary Phytoestrogens on Hormones throughout a Human Lifespan: A Review

et al. 2020

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Dietary phytoestrogens are bioactive compounds with estrogenic activity. With the growing popularity of plant-based diets, the intake of phytoestrogen-rich legumes (especially soy) and legume-derived foods has increased. Evidence from preclinical studies suggests these compounds may have an effect on hormones and health, although the results of human trials are unclear. The effects of dietary phytoestrogens depend on the exposure (phytoestrogen type, matrix, concentration, and bioavailability), ethnicity, hormone levels (related to age, sex, and physiological condition), and health status of the consumer. In this review, we have summarized the results of human studies on dietary phytoestrogens with the aim of assessing the possible hormone-dependent outcomes and health effects of their consumption throughout a lifespan, focusing on pregnancy, childhood, adulthood, and the premenopausal and postmenopausal stages. In pregnant women, an improvement of insulin metabolism has been reported in only one study. Sex hormone alterations have been found in the late stages of childhood, and goitrogenic effects in children with hypothyroidism. In premenopausal and postmenopausal women, the reported impacts on hormones are inconsistent, although beneficial goitrogenic effects and improved glycemic control and cardiovascular risk markers have been described in postmenopausal individuals. In adult men, different authors report goitrogenic effects and a reduction of insulin in non-alcoholic fatty liver patients. Further carefully designed studies are warranted to better elucidate the impact of phytoestrogen consumption on the endocrine system at different life stages.

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Section: Effect Of Phytoestrogen Intake On Hormones Related To Bonmentioning

confidence: 99%

Effects of Dietary Phytoestrogens on Hormones throughout a Human Lifespan: A Review

et al. 2020

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“…Genistein, a phytoestrogen, is one of the main isoflavones in soy and it modulates ER signalling by a genomic effect. [15][16][17] Taking into account the above and focusing on the effect of the estrogens on the lipid profile, the primary outcome of our study was to determine whether calcium, vitamin D and genistein supplementation had a beneficial additive effect on serum lipid profile. The secondary outcome was to determine whether this effect was mediated by polymorphisms in ER genes.…”

Section: Introductionmentioning

confidence: 99%

“…Phytoestrogens are plant‐derived compounds that have structural similarity to estrogen and that are able to bind to the ERs. Genistein, a phytoestrogen, is one of the main isoflavones in soy and it modulates ER signalling by a genomic effect …”

Section: Introductionmentioning

confidence: 99%

Estrogen receptor genes polymorphisms determine serum lipid profile in healthy postmenopausal women treated with calcium, vitamin D, and genistein

Usategui-Martín

Pérez-Alonso

Socorro-Briongos

et al. 2019

J of Cellular Biochemistry

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Cardiovascular risk increases in women after menopause. Unfavorable lipidlipoprotein changes due to a lack of estrogens may have an important role in this context. Estrogen actions are mainly mediated by their binding to two estrogen receptors (ERs) whose signaling may be conditioned by different factors. Calcium, vitamin D, and genistein, among others, cause a beneficial effect on serum lipid profile by its modulation. Some genetic factors can also determine this signal. We determined the possible additive effect of genistein on calcium and vitamin D supplementation regarding serum lipid profile changes and whether ER polymorphisms may mediate in this effect.We performed a prospective, double blind study in which women were randomized in two groups: one group received calcium and vitamin D and the other group received calcium, vitamin D and genistein. Subsequently, we studied rs9340799, rs928554, and rs4986938 ER polymorphisms in both groups. Our results showed that being a carrier of the variant allele G of rs928554 polymorphism was associated with a greater decrease in triglyceride levels and that the homozygous AA genotype of rs9340799 polymorphism was associated with a greater decrease in total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels after calcium, vitamin D, and genistein supplementation. This is the first report showing an association between polymorphisms in ER genes and an improvement of the serum lipid profile after taking calcium, vitamin D, and genistein supplementation in postmenopausal women. It reinforces the hypothesis that genetic factors are crucial in ER signalling. K E Y W O R D S calcium, cardiovascular, estrogen receptor, genistein, polymorphism, vitamin D J Cell Biochem. 2019;120:13115-13120.wileyonlinelibrary.com/journal/jcb

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“…Another study suggests that phytoestrogens like genistein could decrease bone turnover, preventing osteoporosis [276]. However, other clinical trials did not find significant results in improving bone density [277][278][279], so there is a controversy about this ability.…”

Section: Endometrial Cancermentioning

confidence: 99%

Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits

Sharifi‐Rad

Quispe

Imran

et al. 2021

Oxidative Medicine and Cellular Longevity

169

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Genistein is an isoflavone first isolated from the brooming plant Dyer’s Genista tinctoria L. and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein exerts estrogen-like functions. Several biological effects of genistein have been reported in preclinical studies, such as the antioxidant, anti-inflammatory, antibacterial, and antiviral activities, the effects of angiogenesis and estrogen, and the pharmacological activities on diabetes and lipid metabolism. The purpose of this review is to provide up-to-date evidence of preclinical pharmacological activities with mechanisms of action, bioavailability, and clinical evidence of genistein. The literature was researched using the most important keyword “genistein” from the PubMed, Science, and Google Scholar databases, and the taxonomy was validated using The Plant List. Data were also collected from specialized books and other online resources. The main positive effects of genistein refer to the protection against cardiovascular diseases and to the decrease of the incidence of some types of cancer, especially breast cancer. Although the mechanism of protection against cancer involves several aspects of genistein metabolism, the researchers attribute this effect to the similarity between the structure of soy genistein and that of estrogen. This structural similarity allows genistein to displace estrogen from cellular receptors, thus blocking their hormonal activity. The pharmacological activities resulting from the experimental studies of this review support the traditional uses of genistein, but in the future, further investigations are needed on the efficacy, safety, and use of nanotechnologies to increase bioavailability and therapeutic efficacy.

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The Effect of Genistein Supplementation on Vitamin D Levels and Bone Turnover Markers during the Summer in Healthy Postmenopausal Women: Role of Genotypes of Isoflavone Metabolism

Cited by 9 publications

References 27 publications

Effects of Dietary Phytoestrogens on Hormones throughout a Human Lifespan: A Review

Effects of Dietary Phytoestrogens on Hormones throughout a Human Lifespan: A Review

Estrogen receptor genes polymorphisms determine serum lipid profile in healthy postmenopausal women treated with calcium, vitamin D, and genistein

Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits

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