Predictors of Survival in a Group of Patients with Chronic Airflow Obstruction

Piccioni, Pavilio; Caria, E; Bignamini, Elisabetta; Forconi, G; Nebiolo, Franco; Arossa, W; Bugiani, Massimiliano

doi:10.1016/s0895-4356(98)00022-5

Cited by 20 publications

(9 citation statements)

References 29 publications

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“…Despite this restrictive range of functional pulmonary alteration in COPD, the comparison between extreme percentiles of FEV1% in COPD with stage pI NSCLC still detects a significant prognostic gradient (Table 4). This value is in accordance with all the data available on COPD [25].…”

Section: Discussionsupporting

confidence: 92%

Prognostic value of chronic obstructive pulmonary disease in 2994 cases of lung cancer

López-Encuentra

Astudillo

Cerezal

et al. 2005

European Journal of Cardio-Thoracic Surgery

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Section: Discussionsupporting

confidence: 92%

Prognostic value of chronic obstructive pulmonary disease in 2994 cases of lung cancer

López-Encuentra

Astudillo

Cerezal

et al. 2005

European Journal of Cardio-Thoracic Surgery

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“…These data support the findings of others, who have suggested that increased age is associated with worsened survival (31,32). Interestingly, no difference in mortality was noted between males and females with severe emphysema in univariate or multivariate analyses.…”

Section: Discussionsupporting

confidence: 91%

“…Although many investigators have suggested that FEV 1 is inversely associated with mortality (2,3,23,31,36,37), it was not predictive in our cohort using multivariate analysis. Similarly, in contrast to others who have described a decreased Dl CO as strongly predictive of mortality (6)(7)(8)36), we found that lower Dl CO was strongly predictive in univariate models, but its impact weakened in multivariate modeling.…”

Section: Discussioncontrasting

confidence: 88%

Predictors of Mortality in Patients with Emphysema and Severe Airflow Obstruction

Martínez

Foster

Curtis

et al. 2006

Am J Respir Crit Care Med

395

290

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“…The degree of airway obstruction, expressed by FEV 1 , is well known to correlate with survival: the higher the FEV 1 value at the time of selection, the lower the risk of COPD-related death [17, 18, 19]. The significance of PaCO 2 levels is more controversial.…”

Section: Discussionmentioning

confidence: 99%

Are COPD Patients with Nocturnal REM Sleep-Related Desaturations More Prone to Developing Chronic Respiratory Failure Requiring Long-Term Oxygen Therapy?

et al. 2002

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Background: Nocturnal oxygen desaturations (NOD), especially during REM sleep, have been described in patients with COPD. However, the role of NOD in the evolution of COPD to chronic respiratory failure has not been well studied. Objective: The aim of our study was to evaluate whether NOD is a risk factor for the development of chronic respiratory failure in COPD patients. Methods: We studied 34 consecutive COPD patients with a stable daytime PaO₂ >60 mm Hg over a period of 42 months. We classified patients as desaturators (NOD) when episodic desaturations were found mainly during REM sleep, independently of baseline SaO₂ values. Results: At enrolment 19 patients (55.8%) had NOD. Over the follow-up period, 10 patients (29.4%) were included in a long-term oxygen therapy (LTOT) programme (9 were desaturators). The LTOT was initiated a median time of 22 ± 6.8 months after enrolment. Patients who were subsequently prescribed LTOT had lower values of FEV₁ at enrolment, with a higher degree of NOD and PaCO₂. Stable respiratory failure developed earlier in patients with NOD: the two enrolment curves for LTOT differed significantly (log-rank test 2.56, p = 0.005). PaCO₂, NOD and FEV₁ were statistically significantly associated, both in univariate and multivariate Cox proportional hazards analyses, with an increased risk of entering a LTOT programme. Conclusions: We conclude that NOD may represent an independent risk factor for the development of chronic respiratory failure in COPD patients with daytime PaO₂ >60 mm Hg. A larger study is needed to confirm the role of NOD in the natural history of COPD and subsequently to identify the most appropriate therapeutic approach.

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Predictors of Survival in a Group of Patients with Chronic Airflow Obstruction

Cited by 20 publications

References 29 publications

Prognostic value of chronic obstructive pulmonary disease in 2994 cases of lung cancer

Prognostic value of chronic obstructive pulmonary disease in 2994 cases of lung cancer

Predictors of Mortality in Patients with Emphysema and Severe Airflow Obstruction

Are COPD Patients with Nocturnal REM Sleep-Related Desaturations More Prone to Developing Chronic Respiratory Failure Requiring Long-Term Oxygen Therapy?

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