Predictors of prognosis in patients with olfactory disturbance

London, Brian M.; Nabet, Behnam; Fisher, Andrew R.; White, Brigitte; Sammel, Mary D.; Doty, Richard L.

doi:10.1002/ana.21293

Cited by 148 publications

(150 citation statements)

References 27 publications

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“…At this time, olfactory testing is the most sensitive bedside indicator of persisting brain injury. Another reason that olfaction is a good test for remote TBI is that olfaction usually does not recover after TBI [23].…”

Section: Discussionmentioning

confidence: 99%

“…The olfactory testing instrument has normal performance values that are adjusted for age and sex [17][18]. Olfactory testing using this scratch-and-sniff type of testing instrument has been validated for all severities of TBI [19][20][21][22][23]. Motor testing evaluated muscle tone, muscle power testing, upper-limb drift, and the arm-rolling maneuver [24].…”

Section: Neurological Examinationmentioning

confidence: 99%

See 1 more Smart Citation

Headaches among Operation Iraqi Freedom/Operation Enduring Freedom veterans with mild traumatic brain injury associated with exposures to explosions

Ruff

Ruff²,

Wang³

2008

JRRD

109

146

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Abstract-Traumatic brain injury (TBI) is a common injury type among Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) veterans, and headaches are a frequent consequence of TBI. We examined the hypothesis that among veterans who reported mild TBI caused by exposure to an explosion during deployment in OIF/OEF, those with residual neurocognitive deficits would have a higher frequency of headaches and more severe headaches. We evaluated 155 consecutive veterans with neurological examination and neuropsychological testing. We excluded 29 veterans because they did not have mild TBI or they did not complete the evaluation. We analyzed headache pattern, intensity, and frequency. Among the 126 veterans studied, 80 had impairments on neurological examination or neuropsychological testing that were best attributed to TBI. Veterans with impairments had been exposed to more explosions and were more likely to have headache, features of migraine, more severe pain, more frequent headaches, posttraumatic stress disorder, and impaired sleep with nightmares.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Neurological Examinationmentioning

confidence: 99%

Headaches among Operation Iraqi Freedom/Operation Enduring Freedom veterans with mild traumatic brain injury associated with exposures to explosions

Ruff

Ruff²,

Wang³

2008

JRRD

109

146

View full text Add to dashboard Cite

show abstract

“…37 The prognosis of olfactory dysfunction is influenced by certain demographic and clinical factors. Over time, regaining the sense of smell is more likely in females, 38 younger persons, 38,39 those with lesser severity of initial olfactory loss, 39 and those with shorter duration of dysfunction. 39 However, there is no clear understanding of why olfaction issues come and go over time.…”

Section: Discussionmentioning

confidence: 99%

A possible correlation between vitamin D deficiency and loss of smell: 2 case reports

Kruse¹,

Cambron

2011

Journal of Chiropractic Medicine

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Objective: The purpose of this report is to present 2 cases of diminished olfaction that improved with increasing serum levels of vitamin D3. Clinical Features: Both patients were under the care of medical and chiropractic physicians for various complaints. A 47-year-old hyposmic woman was diagnosed with vitamin D deficiency who incidentally noticed a progressive return of her sense of smell while taking vitamin D supplements as prescribed by her medical doctor. A 34-year-old anosmic woman noticed a direct relationship with her ability to smell and vitamin D3 supplementation. Intervention and Outcome: Treatment for the first patient consisted of vitamin D supplementation of 10 000 IU a day. Her serum D3 levels increased substantially over a period of 8 months, at which time she reported a marked improvement in her sense of smell. The second patient was prescribed 50 000 IU of vitamin D a week; and she reported an increased ability to smell, although only the strongest of odors. Conclusion: A link between hypovitaminosis D and a diminished sense of smell was noted in these 2 individuals.

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“…Most clinical literature on olfactory disorders is focused on measurable dysfunction such as anosmia and hyposmia [6] ; today, reliable data on the frequency, origins and spontaneous recovery rates of quantitative smell disorders exist [7,8] . The clinical knowledge of qualitative olfactory disorders is a little different.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Phantosmia: Outcome and Clinical Significance

Landis¹,

Reden²,

Haehner³

2010

ORL

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Background/Aim: Little is known about the clinical significance of phantosmia. The literature on phantosmia indicates that this symptom has a wide range of differential diagnoses. However, most cases of phantosmia remain of unknown origin. Our goal was to follow up patients with idiopathic phantosmia, with special regard to improvement rates and possible severe health conditions preceded by phantosmia of unknown origin. Methods: Forty-four patients with idiopathic phantosmia which had consulted our Ear-Nose-Throat Smell and Taste Clinic over the last 10 years were contacted by telephone and underwent a structured medical interview. Results: None of the patients had developed any severe health condition or Parkinson’s disease. More than 5 years after the occurrence of phantosmia, more than 50% of the patients experienced disappearance (31.8%) or improvement (25%). In the remaining cases, phantosmia did not change (38.7%) or became worse (<5%). Conclusion: The main findings of the present study were that idiopathic phantosmia improves or disappears in almost two thirds of the patients after more than 5 years, and that idiopathic phantosmia seems to be more likely a harmless symptom rather than a reliable predictor of early Parkinson’s disease or other severe diseases.

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Predictors of prognosis in patients with olfactory disturbance

Cited by 148 publications

References 27 publications

Headaches among Operation Iraqi Freedom/Operation Enduring Freedom veterans with mild traumatic brain injury associated with exposures to explosions

Headaches among Operation Iraqi Freedom/Operation Enduring Freedom veterans with mild traumatic brain injury associated with exposures to explosions

A possible correlation between vitamin D deficiency and loss of smell: 2 case reports

Idiopathic Phantosmia: Outcome and Clinical Significance

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