Predictors of Postoperative Atrial Fibrillation after On-Pump Coronary Artery Bypass Grafting: Is Duration of Mechanical Ventilation Time a Risk Factor?

Erdil, Nevzat; Gedik, Ender; Dönmez, Köksal; Erdil, Feray; Aldemir, Mustafa; Battaloğlu, Bektaş; Yoloğlu, Saim

doi:10.5761/atcs.oa.12.02104

Cited by 37 publications

(42 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The incidence of FA observed in this work was 16.7%, which is similar to that described in the literature (Aranki et al., ; Chelazzi et al., ; Creswell et al., ). It is known that the occurrence of FA increases with age (Aranki et al., ; Chelazzi et al., ; Erdil et al., ; Friberg & Bergfeldt, ; Rahman et al., ); we also observed a higher mean age in the FAPO group. It is worth mentioning that the level of the three miRNAs was similar between groups in the preoperative period, as were the clinical and echocardiographic profile—together, these data indicate homogeneity of both groups before surgery.…”

Section: Discussionsupporting

confidence: 77%

Analysis of Circulating miR-1, miR-23a, and miR-26a in Atrial Fibrillation Patients Undergoing Coronary Bypass Artery Grafting Surgery

Feldman

Moreira

Gun

et al. 2017

Annals of Human Genetics

View full text Add to dashboard Cite

Atrial fibrillation (AF) is the most common arrhythmia after cardiac surgery. From a pathophysiological point of view, a myriad of factors such as trauma, atrial dilation, ischemia, mechanical myopericarditis, autonomic imbalance, loss of connexins, AF nest remodeling, inflammation, sutures, and dysfunction caused by postextracorporeal circulation can contribute to postoperative atrial fibrillation (POAF) resulting in a longer hospital stay and consequently higher cost. Recent studies showed that short fragments of RNA, called microRNA (miRNA), can contribute to the development of several cardiovascular diseases, including AF. The aim of this study was to evaluate the levels of circulating miRNAs (miR-1, -23a, and -26a) that can be involved in POAF. Patients submitted to coronary artery bypass graft surgery were grouped in POAF (24 patients) and without POAF (24 patients). Results showed older age, longer clamp-time, and more days in the intensive care unit as well as a longer total hospital stay in the POAF group. Preoperative levels of circulating miRNAs were similar. Analysis of miRNAs revealed significantly lower circulating levels of miRNA-23a (P = 0.02) and -26a (P = 0.01) in the POAF group during the postoperative period. Receiver operating characteristic (ROC) analysis showed the area under the ROC curve of miR-23a and miR-26a for predicting FA was 0.63 (95% confidence interval [CI]: 0.51-0.74; P = 0.02) and 0.66 (95% CI: 0.55-0.77; P = 0.01), respectively. Our data suggests that circulating miRNA-23a and -26a may be involved in the underlying biology of postoperative AF development.

show abstract

Section: Discussionsupporting

confidence: 77%

Analysis of Circulating miR-1, miR-23a, and miR-26a in Atrial Fibrillation Patients Undergoing Coronary Bypass Artery Grafting Surgery

Feldman

Moreira

Gun

et al. 2017

Annals of Human Genetics

View full text Add to dashboard Cite

show abstract

“…[15][16][17] It was reported that the prolonged mechanical ventilation could prolong the hospital and intensive care unit (ICU) stay, 18) increase the burden of patients, and raise the risk of cerebral palsy, postoperative atrial fibrillation or ventilator-associated pneumonia. [19][20][21] Thus, it is necessary to reduce the duration of mechanical ventilation in patients requiring prolonged mechanical ventilation.…”

mentioning

confidence: 99%

Early Rehabilitation Therapy Is Beneficial for Patients With Prolonged Mechanical Ventilation After Coronary Artery Bypass Surgery

Dong

Zhang

et al. 2016

Int. Heart J.

View full text Add to dashboard Cite

SummaryWe investigated the effects of early rehabilitation therapy on prolonged mechanically ventilated patients after coronary artery bypass surgery (CABG).A total of 106 patients who underwent CABG between June 2012 and May 2015 were enrolled and randomly assigned into an early rehabilitation group (53 cases) and a control group (53 cases). The rehabilitation therapy consisted of 6 steps including head up, transferring from supination to sitting, sitting on the edge of bed, sitting in a chair, transferring from sitting to standing, and walking along a bed. The patients received rehabilitation therapy in the intensive care unit (ICU) after CABG in the early rehabilitation group. The control group patients received rehabilitation therapy after leaving the ICU.The results showed that the early rehabilitation therapy could significantly decrease the duration of mechanical ventilation (early rehabilitation group: 8.1 ± 3.3 days; control group: 13.9 ± 4.1 days, P < 0.01), hospital stay (early rehabilitation group: 22.0 ± 3.8 days; control group: 29.1 ± 4.6 days, P < 0.01), and ICU stay (early rehabilitation group: 11.7 ± 3.2 days; control group: 18.3 ± 4.2 days, P < 0.01) for patients requiring more than 72 hours prolonged mechanical ventilation. The results of Kaplan-Meier analysis showed that the proportions of patients remaining on mechanical ventilation in the early rehabilitation group were larger than that in the control group after 7 days of rehabilitation therapy (logrank test: P < 0.01).The results provide evidence for supporting the application of early rehabilitation therapy in patients requiring prolonged mechanical ventilation after CABG. (Int Heart J 2016; 57: 241-246) Key words: Postoperative recovery, Hospital stay, Randomized controlled trial, Intensive care unit C oronary artery disease is the primary cause of death worldwide. 1) Coronary artery bypass surgery (CABG) is commonly used for patients with severe coronary artery disease at the left anterior descending artery, circumflex artery, and right coronary artery.2,3) Cardiac rehabilitation is used for improving functional capacity and reducing cardiovascular mortality and morbidity in patients undergoing CABG. [4][5][6] Previous studies have shown that rehabilitation therapy could significantly reduce the length of hospitalization time, costs and complications, promote cardiac function recovery, and improve the quality of life in patients who underwent CABG. [7][8][9][10][11] Mechanical ventilation was routinely applied after CABG to reduce the power consumption of the respiratory system and the cardiac burden to improve postoperative cardiac recovery. [12][13][14] Due to a system of risk factors (such as the duration of surgery, anesthesia, clinical condition, mode of ventilator therapy, and method of weaning from mechanical ventilation), many patients should receive prolonged mechanical ventilation. [15][16][17] It was reported that the prolonged mechanical ventilation could prolong the hospital and intensive care unit (ICU) stay, 18) incre...

show abstract

“…The independent risk factors for prolonged mechanical ventilation were old age and female gender. In slightly different findings indicate a smaller percentage of coronary artery bypass graft patients (2.3%) require prolonged ventilation (>25hours), but with no significant difference between male and female patients [44].…”

Section: Antibioticsmentioning

confidence: 96%

Nursing Evaluation of Risk Factors Associated with Surgical Site Infection Among Coronary Artery Bypass Graft Patients at King Abdulaziz University Hospital

Johani¹

2017

AJNS

View full text Add to dashboard Cite

Abstract:Surgical site infection is postoperative wound infection that occurs after surgery. The complications in the acute care facilities with up to 60% of surgical site infection cases estimated to be preventable by using evidence-based practice. Not with standing the advances in the coronary artery bypass graft, the rising prevalence of surgical site infection has become a primary concern in the infection control practices. The current study amid to evaluate the risk factors associated with the surgical site infections among coronary artery bypass graft patients and, to assess nurses compliance to bundle care to prevent surgical site infection. The study followed a quantitative, retrospective design and was carried out in King Abdulaziz University Hospital in Jeddah city. All sample (n= 120) coronary artery by-pass graft patient's record complied between January 2011 to December 2013.The study revealed statistically significant results between the preference of surgical site infection and demographic factor e.g. body mass index, patient risk factors such as diabetes type1 and 2, selected pre-operative factors e.g. Methicilin-resistant staphylococcus aurous, postoperative factors e.g. rewiring, dressing, ventilation and low cardiac output. This study established that the compliance with the bundle was proven to be effective in reducing risk factors to surgical site infection however nurses adherence to surgical site infection bundle care were incomplete and required more enforcement to comply. Based on the finding, the investigator recommended that nurses should be aware of the importance of adhering to surgical site infection bundles. Nurses should not only be educated on the importance of the bundles, but on how effectives apply the bundles at different stages.

show abstract

Predictors of Postoperative Atrial Fibrillation after On-Pump Coronary Artery Bypass Grafting: Is Duration of Mechanical Ventilation Time a Risk Factor?

Cited by 37 publications

References 22 publications

Analysis of Circulating miR-1, miR-23a, and miR-26a in Atrial Fibrillation Patients Undergoing Coronary Bypass Artery Grafting Surgery

Analysis of Circulating miR-1, miR-23a, and miR-26a in Atrial Fibrillation Patients Undergoing Coronary Bypass Artery Grafting Surgery

Early Rehabilitation Therapy Is Beneficial for Patients With Prolonged Mechanical Ventilation After Coronary Artery Bypass Surgery

Nursing Evaluation of Risk Factors Associated with Surgical Site Infection Among Coronary Artery Bypass Graft Patients at King Abdulaziz University Hospital

Contact Info

Product

Resources

About