Predictors of new-onset depressive disorders – Results from the longitudinal Finnish Health 2011 Study

Markkula, Niina; Marola, Niko; Nieminen, Tarja; Koskinen, Seppo; Saarni, Samuli I.; Härkänen, Tommi; Suvisaari, Jaana

doi:10.1016/j.jad.2016.08.051

Cited by 22 publications

(20 citation statements)

References 64 publications

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“…Table summarizes the characteristics of the 42 included articles. These 42 articles were derived from 40 cohort studies; among these, 16 reported results regarding AUD, 29 regarding alcohol intake and three regarding both. A total of 338 426 participants were included.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Effect of alcohol use disorders and alcohol intake on the risk of subsequent depressive symptoms: a systematic review and meta‐analysis of cohort studies

Wang

et al. 2020

Addiction

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Background and Aims Alcohol use disorders (AUD) are often comorbid with depressive symptoms. Cohort studies on the association between AUD and subsequent depressive symptoms have produced inconsistent results. Moreover, regarding alcohol intake, the risk of developing depressive symptoms might vary with alcohol intake level. We aimed to investigate the association between AUD, alcohol intake and subsequent depressive symptoms. Design and Setting We conducted a systematic search in PubMed, Embase and PsycINFO for cohort studies on the association between AUD or alcohol intake and subsequent depressive symptoms. Participants We included 338 426 participants from 42 studies. Six and four studies analyzed only females and males, respectively. Measurements We combined risk estimates for developing depressive symptoms using a random‐effects model. We divided alcohol intake into abstinence, light (0–84 g/week), moderate (85–168 g/week) and heavy drinking (> 168 g/week or > 48 g/day at least weekly). We conducted a categorical analysis to compare the risk of depressive symptoms between abstinence and different intake categories. Further, we conducted a dose–response analysis to investigate the alcohol–depression association. Findings We analyzed 42 studies (follow‐up time: 1–40 years). AUD was associated with significantly increased risk of subsequent depressive symptoms [relative risk (RR) = 1.57, 95% confidence interval (CI) = 1.41–1.76]. Regarding alcohol intake, heavy drinking had an increased risk of depressive symptoms; however, the association was only significant when controls were limited to non‐heavy drinkers (RR = 1.13, 95% CI = 1.05–1.22). Taking into consideration the possibility of publication bias and confounding factors made the association non‐significant. We observed J‐shaped associations in both categorical and dose–response analyses where light‐moderate drinking had a significantly decreased risk of depression, while heavy drinking did not show a significant association with depressive symptoms compared with non‐drinkers. Conclusion Alcohol use disorders are associated with increased the risk of subsequent depressive symptoms. Heavy drinking does not significantly predict occurrence of depressive symptoms after adjusting for potential confounders.

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Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…We included 17 data sets from 16 articles regarding the effect of AUD on the risk of subsequent depressive symptoms in the final analysis. The random‐effects pooled estimate was 1.57 (1.41–1.76) and there was no evidence for heterogeneity (Fig.…”

Section: Effect Of Aud On the Risk Of Subsequent Depressive Symptomsmentioning

confidence: 99%

Effect of alcohol use disorders and alcohol intake on the risk of subsequent depressive symptoms: a systematic review and meta‐analysis of cohort studies

Wang

et al. 2020

Addiction

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“…Since indicators of childhood adversity are correlated and tend to cosegregate in such a way that being exposed to one type of childhood adversity increases the risk of exposure to another (Sheikh, 2017a;Sheikh et al, 2016b), a dose-response effect of childhood adversity on psychological distress is more meaningful (Björkenstam et al, 2015;Markkula et al, 2017;Sheikh, 2017b). Six indicators of childhood adversity (mother's education, father's education, subjective childhood financial conditions, and three kinds of adverse childhood experiences) were measured retrospectively in Tromsø VI, to create a childhood adversity score.…”

Section: Exposure (Childhood Adversity)mentioning

confidence: 99%

The potential protective effect of friendship on the association between childhood adversity and psychological distress in adulthood: A retrospective, preliminary, three-wave population-based study

Sheikh

2018

Journal of Affective Disorders

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“…We use the term "adversities" in this paper to refer to the following negative childhood experiences: parental divorce, serious conflicts within the family, financial difficulties within the family, parents' frequent unemployment, parents' serious disease or disability, parental mental health and alcohol use-related problems, one's own serious or chronic illness, and bullying ( Table 1). The set of experiences assessed in this study have been investigated previously in the Finnish general population surveys Health 2000 and Health 2011, and found to be associated with adult mental disorders, including anxiety, depressive, alcohol use, and comorbid disorders (Markkula et al, 2017;Pirkola et al, 2005), heavy drinking (Kestilä et al, 2008), and daily smoking (Kestilä et al, 2006) in early adulthood. The adversities are also associated with shorter telomere length (Kananen et al, 2010), which is a biological marker of stress exposure (Mathur et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Childhood adversities and clinical symptomatology in first-episode psychosis

Lindgren

Mäntylä

Rikandi

et al. 2017

Psychiatry Research

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In addition to severe traumatic experiences, milder, more common childhood adversities reflecting psychosocial burden may also be common in people with psychotic disorders and have an effect on symptomatology and functioning. We explored eleven negative childhood experiences and their influence on clinical symptoms among young adults with first-episode psychosis (FEP, n = 75) and matched population controls (n = 51). Individuals with FEP reported more adversities than controls. Specifically serious conflicts within the family, bullying at school, maternal mental health problems, and one's own and parents' serious illness during childhood were experienced by the patients more often than by controls. In the FEP group, the severity of adversity was associated with increased anxiety, manic, and obsessive-compulsive symptoms, but not with the severity of positive psychotic symptoms. Adversity produced a more pronounced effect on symptoms in male patients than in female patients. To conclude, in line with earlier studies of more chronic psychosis, a majority of the participants with FEP reported exposure to childhood adversities, with the FEP group reporting more adversities than controls. High levels of mood and anxiety symptoms in patients with FEP may be related to cumulative exposure to childhood adversities. This should be taken into account in the treatment for FEP.

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Predictors of new-onset depressive disorders – Results from the longitudinal Finnish Health 2011 Study

Cited by 22 publications

References 64 publications

Effect of alcohol use disorders and alcohol intake on the risk of subsequent depressive symptoms: a systematic review and meta‐analysis of cohort studies

Effect of alcohol use disorders and alcohol intake on the risk of subsequent depressive symptoms: a systematic review and meta‐analysis of cohort studies

The potential protective effect of friendship on the association between childhood adversity and psychological distress in adulthood: A retrospective, preliminary, three-wave population-based study

Childhood adversities and clinical symptomatology in first-episode psychosis

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