Childhood adversities and clinical symptomatology in first-episode psychosis

Lindgren, Maija; Mäntylä, Teemu; Rikandi, Eva; Holm, Minna; Morales‐Muñoz, Isabel; Kieseppä, Tuula; Mantere, Outi; Suvisaari, Jaana

doi:10.1016/j.psychres.2017.08.070

Cited by 25 publications

(22 citation statements)

References 74 publications

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“…Five studies [93][94][95][96][97] reported findings on the association between the frequency of CT and positive symptom severity (Table 4). An additional study focused on severity of delusions 98 in a large BD sample.…”

Section: Childhood Trauma and Mood And Psychotic Symptomsmentioning

confidence: 99%

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

Quidé¹,

Tozzi²,

Corcoran³

et al. 2020

NDT

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Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on retrospective and cross-sectional studies in adults with BD. The first objective of this selective review is to characterize the short-term effects of CT in the development of BD by focusing on studies in young people. The second objective is to describe the longer-term consequences of CT by considering studies with adult participants. This review first outlines the most prominent hypotheses linking CT exposure and the onset of BD. Then, it summarizes the psychological and biological risk factors implicated in the development of BD, followed by a discussion of original studies that investigated the role of CT in young people with early-onset BD, youths at increased risk of developing BD, or young people with BD with a focus on subclinical and clinical outcome measures. The review considers additional biological and psychological factors associated with a negative impact of CT on the long-term course of BD in later adulthood. Finally, we discuss how the integration of information of CT can improve ongoing early identification of BD and mitigate severe clinical expression in later adulthood.

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Section: Childhood Trauma and Mood And Psychotic Symptomsmentioning

confidence: 99%

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

Quidé¹,

Tozzi²,

Corcoran³

et al. 2020

NDT

View full text Add to dashboard Cite

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“…Thirdly, in recent decades, traditional views of psychosis as a symptom of underlying or progressive brain disease have been questioned (Cooke et al, 2014), with new evaluations of the role of psychosis in wider social contexts and in a variety of life crises (Beard et al, 2013;Lindgren et al, 2017;Mansueto and Faravelli, 2017). Viewed in this light, many psychotic states can be interpreted as reactions to difficult life situations and/or traumatic events rather than as symptoms of biological disorders (Holma and Aaltonen, 1998;Read et al, 2005).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The family-oriented open dialogue approach in the treatment of first-episode psychosis: Nineteen–year outcomes

Bergström

Seikkula

Alakare

et al. 2018

Psychiatry Research

124

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Open Dialogue (OD) is a family-oriented early intervention approach which has demonstrated good outcomes in the treatment of first-episode psychosis (FEP). Nevertheless, more evidence is needed. In this register-based cohort study the long-term outcomes of OD were evaluated through a comparison with a control group over a period of approximately 19 years. We examined the mortality, the need for psychiatric treatment, and the granting of disability allowances. Data were obtained from Finnish national registers regarding all OD patients whose treatment for FEP commenced within the time of the original interventions (total N = 108). The control group consisted of all Finnish FEP patients who had a follow-up of 19-20 years and who were guided to other Finnish specialized mental healthcare facilities (N = 1763). No difference between the samples was found regarding the annual incidence of FEP, the diagnosis, and suicide rates. Over the entire follow-up, the figures for durations of hospital treatment, disability allowances, and the need for neuroleptics remained significantly lower with OD group. Findings indicated that many positive outcomes of OD are sustained over a long time period. Due to the observational nature of the study, randomized trials are still needed to provide more information on effectiveness of approach.

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“…Our controls were recruited from the general population via the Population Register Centre, and only a lifetime history of psychotic disorder was used as an exclusion criterion. Consequently, subclinical depressive and anxiety symptoms were relatively common 81 , and there were no differences, for instance, in alcohol or cannabis use between patients and controls. While being matched with age, the gender distribution in our patient and control samples was not equal.…”

Section: Discussionmentioning

confidence: 92%

Elevated serum chemokine CCL22 levels in first-episode psychosis: associations with symptoms, peripheral immune state and in vivo brain glial cell function

et al. 2020

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Several lines of research support immune system dysregulation in psychotic disorders. However, it remains unclear whether the immunological marker alterations are stable and how they associate with brain glial cell function. This longitudinal study aimed at investigating whether peripheral immune functions are altered in the early phases of psychotic disorders, whether the changes are associated with core symptoms, remission, brain glial cell function, and whether they persist in a one-year follow-up. Two independent cohorts comprising in total of 129 first-episode psychosis (FEP) patients and 130 controls were assessed at baseline and at the one-year follow-up. Serum cyto-/ chemokines were measured using a 38-plex Luminex assay. The FEP patients showed a marked increase in chemokine CCL22 levels both at baseline (p < 0.0001; Cohen's d = 0.70) and at the 12-month follow-up (p = 0.0007) compared to controls. The group difference remained significant (p = 0.0019) after accounting for relevant covariates including BMI, smoking, and antipsychotic medication. Elevated serum CCL22 levels were significantly associated with hallucinations (ρ = 0.20) and disorganization (ρ = 0.23), and with worse verbal performance (ρ = −0.23). Brain glial cell activity was indexed with positron emission tomography and the translocator protein radiotracer [ 11 C]PBR28 in subgroups of 15 healthy controls and 14 FEP patients with serum CCL22/CCL17 measurements. The distribution volume (V T) of [ 11 C] PBR28 was lower in patients compared to controls (p = 0.026; Cohen's d = 0.94) without regionally specific effects, and was inversely associated with serum CCL22 and CCL17 levels (p = 0.036). Our results do not support the over-active microglia hypothesis of psychosis, but indicate altered CCR4 immune signaling in early psychosis with behavioral correlates possibly mediated through cross-talk between chemokine networks and dysfunctional or a decreased number of glial cells.

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Childhood adversities and clinical symptomatology in first-episode psychosis

Cited by 25 publications

References 74 publications

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

The family-oriented open dialogue approach in the treatment of first-episode psychosis: Nineteen–year outcomes

Elevated serum chemokine CCL22 levels in first-episode psychosis: associations with symptoms, peripheral immune state and in vivo brain glial cell function

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