Predictors of low bone mineral density in elderly males with chronic obstructive pulmonary disease: the role of body mass index

Coin, Alessandra; Sergi, Giuseppe; Marín, Sara; Vianello, Andrea; Perissinotto, Egle; Sarti, Silvia; Rinaldi, Giulia; Mosele, Marco; Inelmen, Eminè Meral; Enzi, Giuliano; Manzato, Enzo

doi:10.3109/13685531003657784

Cited by 24 publications

(8 citation statements)

References 25 publications

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“…As mentioned above, osteoporosis and sarcopenia have common causal factors such as low levels of vitamin D, testosterone, estrogen, and insulin, as well as, reduced calorie intake and malnutrition (9, 10, 11). The present study identified that sarcopenia can increase the risk of osteoporosis and may lead to increased risk of bone fracture.…”

Section: Discussionmentioning

confidence: 99%

“…In recent studies, sarcopenia is defined as a systemic continuous decrease in skeletal muscle strength and muscle mass so that the diagnosis of sarcopenia must be supported by decreased muscle mass and functional muscle strength (8). Until now, many studies of muscle mass and BMD have been carried out (9, 10, 11), and they showed that low muscle mass is correlated with low BMD. Unfortunately, their study populations were inconsistent and their definitions of sarcopenia different.…”

Section: Introductionmentioning

confidence: 99%

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The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People

et al. 2014

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The purpose of this study was to predict osteoporosis risk as decreasing muscle mass and to declare the cut-off value of low muscle mass in an elderly Korean population. This study was based on data from the 2008-2010 Korea National Health and Nutritional Examination Surveys (KNHANES). The subjects included 1,308 men and 1,171 women over 65 yr. Bone mineral density (BMD) and appendicular skeletal muscle (ASM) were measured by dual energy X-ray absorptiometry (DXA), and appendicular skeletal muscle was adjusted by height as a marker of sarcopenia. After confirming the correlation between low muscle mass and BMD, the best cut-off value of muscle mass to estimate osteoporosis was suggested through the receiver operating characteristic (ROC) curve. For both men and women, BMD correlated positively with low muscle mass when ASM/Ht2 was used as a marker for sarcopenia. The ROC curve showed that ASM/Ht2 was the best marker for osteoporosis at a cut-off value of 6.85 kg/m2 for men and 5.96 kg/m2 for women. When these cut-off values were used to determine sarcopenia, the risk of osteoporosis increased 4.14 times in men and 1.88 times in women. In particular, men (OR 2.12) with sarcopenia were more greatly affected than women (OR 1.15), even after adjusting for osteoporosis risk factors. In elderly Korean people, sarcopenia is positively correlated with BMD and there is a strong correlation between sarcopenia and osteoporosis with risk of bone fracture.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People

et al. 2014

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“…Several studies have reported significant correlation between sarcopenia and osteoporosis and/or BMD. Coin et al124 detected a significant higher prevalence of osteoporosis in sarcopenic groups compared with non-sarcopenic groups (46% vs. 0%; P <0.05). Bolton et al similarly reported a very high prevalence of osteoporosis (50%) and osteopenia (50%) in cachectic COPD patients 125.…”

Section: Risk Factors For Osteoporosis In Copdmentioning

confidence: 95%

Osteoporosis in Chronic Obstructive Pulmonary Disease

Sarkar

Bhardwaj

Madabhavi

et al. 2015

Clin Med Insights Circ Respir Pulm Med

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Chronic obstructive pulmonary disease (COPD) is a lifestyle-related chronic inflammatory pulmonary disease associated with significant morbidity and mortality worldwide. COPD is associated with various comorbidities found in all stages of COPD. The comorbidities have significant impact in terms of morbidity, mortality, and economic burden in COPD. Management of comorbidities should be incorporated into the comprehensive management of COPD as this will also have an effect on the outcome in COPD patients. Various comorbidities reported in COPD include cardiovascular disease, skeletal muscle dysfunction, anemia, metabolic syndrome, and osteoporosis. Osteoporosis is a significant comorbidity in COPD patients. Various risk factors, such as tobacco smoking, systemic inflammation, vitamin D deficiency, and the use of oral or inhaled corticosteroids (ICSs) are responsible for its occurrence in patients with COPD. This review will focus on the prevalence, pathogenesis, risk factors, diagnosis, and treatment of osteoporosis in COPD patients.

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“…Thus the prevalence of osteoporosis is higher in patients with COPD and low body mass index [174] and the same is true of sarcopenia, the main cause of weight loss in COPD, suggesting a common factor for these two extrapulmonary manifestations of COPD [175].…”

Section: Doi: 101183/0903193600134014mentioning

confidence: 96%

Ageing and the border between health and disease

2014

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Ageing is associated with a progressive degeneration of the tissues, which has a negative impact on the structure and function of vital organs and is among the most important known risk factors for most chronic diseases. Since the proportion of the world's population aged .60 years will double in the next four decades, this will be accompanied by an increased incidence of chronic age-related diseases that will place a huge burden on healthcare resources.There is increasing evidence that many chronic inflammatory diseases represent an acceleration of the ageing process. Chronic pulmonary diseases represents an important component of the increasingly prevalent multiple chronic debilitating diseases, which are a major cause of morbidity and mortality, particularly in the elderly. The lungs age and it has been suggested that chronic obstructive pulmonary disease (COPD) is a condition of accelerated lung ageing and that ageing may provide a mechanistic link between COPD and many of its extrapulmonary effects and comorbidities. In this article we will describe the physiological changes and mechanisms of ageing, with particular focus on the pulmonary effects of ageing and how these may be relevant to the development of COPD and its major extrapulmonary manifestations. @ERSpublications Premature ageing of the lung may constitute pathogenetic mechanisms contributing to COPD

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Predictors of low bone mineral density in elderly males with chronic obstructive pulmonary disease: the role of body mass index

Cited by 24 publications

References 25 publications

The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People

The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People

Osteoporosis in Chronic Obstructive Pulmonary Disease

Ageing and the border between health and disease

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