The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People

Kim, Sun‐Young; Won, Chang Won; Kim, Byung Sung; Choi, Hyun Rim; Moon, Min Young

doi:10.3346/jkms.2014.29.7.995

Cited by 76 publications

(65 citation statements)

References 33 publications

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“…Decreased muscle mass and bone mineral density are significant changes that occur with aging, and these are often associated with an inability to adapt to the environment, which results in falls, functional disability, increased hospitalization, decreased quality of life, and increased mortality18 ) . Several studies have reported a correlation between BMD and weight, and muscle mass in elderly women19 ) .…”

Section: Discussionmentioning

confidence: 99%

Association of ACTN3 polymorphisms with BMD, and physical fitness of elderly women

2016

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[Purpose] Association of ACTN3 polymorphism with bone mineral density and the physical fitness of elderly women is still unclear. Therefore, this study investigated the association between ACTN3 genotype and bone mineral density, and the physical fitness of elderly women. [Subjects and Methods] Sixty-eight elderly women (67.38 ± 3.68 years) were recruited at a Seongbuk-Gu (Seoul, Korea) Medical Service Public Health Center. Measurements of physical fitness included muscle strength, muscle endurance, flexibility, agility, balance and VO2max. Bone mineral density (BMD), upper limb muscle mass, lower limb muscle mass, percent body fat and body fat mass for the entire body were measured by dual-energy X-ray absorptiometry and an analyzer. Genotyping for the ACTN3 R577X (rs1815739) polymorphism was performed using the TaqMan approach. [Results] ACTN3 gene distribution of subjects were in the Hardy-Weinberg equilibrium (p=0.694). The relative bone mineral density trunk, pelvis and spine differed significantly among the ACTN3 genotypes. There were no significant differences among bone mineral densities of the head, arms, legs, ribs and total, but the RR genotype tended to be higher than other genotypes. Physical fitness was not significantly different among the ACTN3 genotypes. [Conclusion] These results suggest that ACTN3 gene polymorphisms could be used as one of the genetic determinants of bone mass in elderly women, and in particular, they indicate that individuals with the RR genotype have higher BMD and bone mineral composition.

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Section: Discussionmentioning

confidence: 99%

Association of ACTN3 polymorphisms with BMD, and physical fitness of elderly women

2016

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“…Sarcopenia, defined as a syndrome characterised by progressive and generalised loss of skeletal muscle mass and strength, is common in those with chronic obstructive pulmonary disease, ESRD and congestive heart failure . The prevalence of sarcopenia in the elderly ranges from 0.9 to 24.2% . In Asia, older men are more likely to get sarcopenia than older women …”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8] The prevalence of sarcopenia in the elderly ranges from 0.9 to 24.2%. [9][10][11] In Asia, older men are more likely to get sarcopenia than older women. 12 Obesity is associated with a heightened risk for mortality in the general population.…”

Section: Introductionmentioning

confidence: 99%

Association between obesity with low muscle mass and dialysis mortality

Tseng

Wang

et al. 2017

Internal Medicine Journal

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From a total of 176 age-matched patients, the incidence rates of mortality for different groups were 3.7, 7.8, 10.3 and 16.5 per 1000 person-months. After adjusting for continuous variables, SMMI was independently associated with mortality. The difference between groups A and D was more significant in women than in men after multivariate adjustment (adjusted hazard ratios: 7.465 vs 1.682) (P = 0.035 and 0.553). The discriminative power of SMMI to predict 5-year mortality was 0.700 for men and 0.750 for women, and the best cut-off values were 11.1 and 8.4 kg/m CONCLUSIONS: Low muscle mass was associated with dialysis mortality. Obesity with low muscle mass was a predictor for dialysis mortality in women.

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“…[12] Bone mineral density (BMD) has a positive correlation between muscle mass and muscle strength, and therefore, sarcopenia is related to osteoporosis. [34] In the process of aging of these muscles, the degree of intramuscular fatty degeneration increased, which is also associated with a decrease in mobility function. [5] Osteoporotic hip fracture is an important geriatric disease that threatens the life of the patient and impairs quality of life and is rapidly increasing with aging in elderly people over 65 years old.…”

Section: Introductionmentioning

confidence: 99%

Bone Mineral Density and Fatty Degeneration of Thigh Muscles Measured by Computed Tomography in Hip Fracture Patients

Hahn

Won

2016

J Bone Metab

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BackgroundRecently, as an independent fracture factor from Bone mineral density (BMD), muscle weakness due to the fatty degeneration of thigh muscles have been attracting attentions as causes of hip fracture. The purpose of this study is to investigate the correlation between the body composition and BMD and fatty degeneration of thigh muscles of the female patients over 65 years old with osteoporotic hip fracture.MethodsThis study was conducted with 178 female osteoporotic hip fracture patients. Total hip BMD was measured using dual energy X-ray absorptiometry. Cross-sectional area (CSA), cross-sectional muscle area (CSmA), muscle attenuation coefficient (MAC), and intramuscular adipose tissue (IMAT) of gluteus maximus, hip abductors, quadriceps and hamstring muscle were measured with computed tomography. Normalized IMAT (nIMAT) was calculated by dividing the fat area in the muscle into the size of each muscle. The correlation between each measurement is examined then the differences between the intertrochanteric fracture group and the femoral neck fracture group were analyzed.ResultsCSmA and MAC of quadriceps were the largest and nIMAT was the lowest. CSA and CSmA of the four muscles showed a statistically significant positive correlation with weight, height, body mass index (BMI), and BMD. MAC of 2 gluteal muscles was positively correlated with weight, BMI and BMD. nIMAT of all four muscles was positively correlation with weight and BMI but nIMAT of 2 mid-thigh muscles was positively correlation with BMD.ConclusionsMuscle size and fatty degeneration in the thigh muscles were most positively correlated with the body weight. BMD was positively correlation with CSA and CSmA of all thigh muscles, and MAC of 2 gluteal muscles and fatty degeneration of 2 mid-thigh muscles. There was no statistically significant difference in the size of the femoral muscle and the degree of fatty degeneration between the two fracture groups.

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The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People

Cited by 76 publications

References 33 publications

Association of ACTN3 polymorphisms with BMD, and physical fitness of elderly women

Association of ACTN3 polymorphisms with BMD, and physical fitness of elderly women

Association between obesity with low muscle mass and dialysis mortality

Bone Mineral Density and Fatty Degeneration of Thigh Muscles Measured by Computed Tomography in Hip Fracture Patients

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