Predictors of later bipolar disorder in patients with subthreshold symptoms

Homish, Gregory G.; Marshall, Dori; Dubovsky, Steven; Leonard, Kenneth E.

doi:10.1016/j.jad.2012.06.020

Cited by 24 publications

(29 citation statements)

References 33 publications

(41 reference statements)

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“…There was a small group of individuals currently remitted for MDD who endorsed significantly higher lifetime mania symptoms, although not clinically elevated to the point that it would be captured in diagnostic interviews. This finding is consistent with the presence of many prodromal symptoms before the development and awareness of BD, including mood lability and elation, swings or cyclothymic features, racing thoughts, irritability, and psychomotor activation, (many of the mania factors in the MOODS‐SR) . This group also endorsed more severe lifetime depressive symptoms in four factors.…”

Section: Discussionsupporting

confidence: 82%

“…This finding is consistent with the presence of many prodromal symptoms before the development and awareness of BD, including mood lability and elation, swings or cyclothymic features, racing thoughts, irritability, and psychomotor activation, (many of the mania factors in the MOODS-SR). 43,44 This group also endorsed more severe lifetime depressive symptoms in four factors. Sev may represent a distinct MDD group with substhreshold manic symptomology, who…”

Section: Discussionmentioning

confidence: 89%

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Cluster analysis with MOODS‐SR illustrates a potential bipolar disorder risk phenotype in young adults with remitted major depressive disorder

et al. 2018

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Objectives: Delays in the diagnosis and detection of bipolar disorder can lead to adverse consequences, including improper treatment and increased suicide risk. The Mood Spectrum Self-Report Measure (MOODS-SR) was designed to capture the full spectrum of lifetime mood symptomology with factor scores for depression and mania symptom constellations. The utility of the MOODS-SR as a tool to investigate homogenous subgroups was examined, with particular focus on a possible bipolar risk subgroup. Moreover, potential patterns of differences in MOODS-SR subtypes were probed using cognitive vulnerabilities, neuropsychological functioning, and ventral striatum connectivity. Methods: K-mean cluster analysis based upon factor scores of MOODS-SR was used to determine homogenous subgroupings within a healthy and remitted depressed young adult sample (N=86). Between-group comparisons (based upon cluster sub-groupings) were conducted on measures of cognitive vulnerabilities, neuropsychological functioning, and ventral striatum rs-fMRI connectivity. Results: Three groups of participants were identified: one with minimal symptomology, one with moderate primarily depressive symptomology, and one with more severe manic and depressive symptomology. Differences in impulsivity, neuroticism, conscientiousness, facial perception accuracy, and rs-fMRI connectivity exist between moderate and severe groups. Conclusions: Within a sample of people with and without depression histories, a severe subgroup was identified with potentially increased risk of developing bipolar disorder through use of the MOODS-SR. This small subgroup had higher levels of lifetime depression and mania symptoms. Additionally, differences in traits, affective processing, and connectivity exist between those with a more prototypic unipolar subgrouping and those with potential risk for developing bipolar disorder.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 89%

Cluster analysis with MOODS‐SR illustrates a potential bipolar disorder risk phenotype in young adults with remitted major depressive disorder

et al. 2018

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“…the presence of the same symptom structure at different points of time) and heterotypic (i.e. changes in symptom structure across time) continuity of symptoms are possible (3)(4)(5). For example, bipolar disorder characteristic symptoms (e.g.…”

Section: Introductionmentioning

confidence: 99%

Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample

Cunha

Asevedo

Mansur

et al. 2015

Acta Psychiatr Scand

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“…As a result, many scholars have begun to seek the relationship between BD and anxiety disorders. For example, the 2013 National Epidemiological Survey on Alcohol and Related Conditions (NESARC) found that in subjects with elation or irritability, generalized anxiety disorder can be a good predictor of later hypomania [ 16 ]. Another study found that subjects who did not have panic disorder before they were recruited had a higher rate of developing BD if they experienced a panic attack than if they did not have a panic attack [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Do some anxiety disorders belong to the prodrome of bipolar disorder? A clinical study combining retrospective and prospective methods to analyse the relationship between anxiety disorder and bipolar disorder from the perspective of biorhythms

Zhou

Zhang

et al. 2017

BMC Psychiatry

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BackgroundIn clinical practice, some patients diagnosed with anxiety disorder (AD) may develop bipolar disorder (BD) many years later, and some cases of AD may be cured by the use of mood stabilizers. However, the relationship between AD and BD should be explored further.MethodTo track how many cases of AD turned to BD and to discover the differences between them, we recruited 48 patients diagnosed with BD, who were assigned to the BD group for the retrospective analysis, and we also recruited 186 patients diagnosed with AD at enrolment; this latter group was asked to complete follow-up surveys conducted 3 months, 6 months, 12 months and 18 months after the primary stage of the study. We defined another two groups according to the usage of mood stabilizers, the rates of reduction in scores on the Hamilton Anxiety Scale and Yale-Brown Obsessive Compulsive Scale, and the changes in Clinical Global Impression scores at different follow-up times: the anxiety group and the atypical BD group (who used mood stabilizers to treat AD). All subjects also completed the NEO Five-Factor Inventory and supplied blood samples to be tested for several endocrine indices (TSH, T3, FT3, T4, FT4, ACTH,PTC) and inflammatory cytokines (IL-6, IL-8, IL-10, TNF-α, CRP) at enrolment.ResultsIn total, 14 subjects developed BD by the end of the study. One hundred eleven subjects were included in the anxiety group. Sixty-three subjects were assigned to the atypical BD group, and they had similar features to the 48 subjects in the BD group in terms of personality traits, abnormality rates of endocrine indices and levels of inflammatory cytokines. From the anxiety group to the atypical BD group and then the BD group, the age of first onset gradually decreased, while the frequency of onset and the score of suicidal ideation gradually increased. Furthermore, the atypical BD group showed markedly higher levels of TSH, IL-6, TNF-α and CRP than the other two groups.ConclusionsSome ADs with unique features might belong to the prodromal stage or the atypical presentation of BD, and recognizing these ADs early will economize many medical resources.Electronic supplementary materialThe online version of this article (10.1186/s12888-017-1509-6) contains supplementary material, which is available to authorized users.

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Predictors of later bipolar disorder in patients with subthreshold symptoms

Cited by 24 publications

References 33 publications

Cluster analysis with MOODS‐SR illustrates a potential bipolar disorder risk phenotype in young adults with remitted major depressive disorder

Cluster analysis with MOODS‐SR illustrates a potential bipolar disorder risk phenotype in young adults with remitted major depressive disorder

Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample

Do some anxiety disorders belong to the prodrome of bipolar disorder? A clinical study combining retrospective and prospective methods to analyse the relationship between anxiety disorder and bipolar disorder from the perspective of biorhythms

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