Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample

Cunha, Graccielle R.; Asevedo, Elson; Mansur, Rodrigo B.; Zugman, André; Pan, Pedro Mário; Gadelha, Ary; Belangero, Síntia Iole; Rizzo, Lucas B.; Coelho, Roberta Paula Schell; Stertz, Laura; Cogo-Moreira, Hugo; Grassi‐Oliveira, Rodrigo; Teixeira, Antônio Lúcio; Kauer-Sant'Anna, M.; Mari, Jair J.; Miguel, Eurí­pedes Constantino; Bressan, Rodrigo A.; Brietzke, Elisa

doi:10.1111/acps.12453

Cited by 9 publications

(8 citation statements)

References 39 publications

(49 reference statements)

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“…While the majority of such studies have been conducted with adults, one study did find preliminary evidence of high serum uric acid in adolescents with depression compared to a control group, which may indicate redox disruption [56]. A separate study documented a positive relationship between increased oxidative stress and elevated externalizing problem behaviors in a large community sample of 6–13 year old children [57]. A positive association between oxidative stress and mental health problems also was observed in a study of 495 children aged 6–12.…”

Section: Introductionmentioning

confidence: 99%

Childhood adversity, mental health, and oxidative stress: A pilot study

et al. 2019

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Childhood adversity is a potent risk factor for mental health conditions via disruptions to stress response systems. Dysregulations in oxidative stress systems have been associated with both childhood adversity and several psychological disorders (e.g., major depressive disorder) in adult populations. However, few studies have examined associations between childhood adversity, oxidative stress, and mental health in pediatric populations. Childhood adversity (Adverse Childhood Events [ACE]), oxidative stress [F2 t -isoprostanes (IsoPs)], and mental health pathology were assessed in 50 adolescent females recruited primarily through the Department of Youth Services. Standard ordinary least squares regression models were run co-varying for age, race/ethnicity, adolescent nicotine use, study condition, and parent history of ACEs. Adolescents who reported experiencing four or more ACEs had significantly elevated IsoP levels. Further, internalizing symptom scores across diagnoses were significantly associated with elevated IsoPs, whereas no externalizing symptoms scores, except Attention Deficit Hyperactivity Disorder, were related to altered oxidative stress. Results indicate that IsoPs may be a global marker of childhood adversity and mental health symptomatology, particularly within internalizing symptom domains. A limitation is that body mass index was not collected for this sample. Future studies are needed to replicate and extend these findings in larger, more diverse samples.

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Section: Introductionmentioning

confidence: 99%

Childhood adversity, mental health, and oxidative stress: A pilot study

et al. 2019

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“…There are few studies that show high levels of CCL-11 in ASD [60][61][62]. A meta-analysis reviewed the results of 17 ASD studies with a total sample size of 743 patients with ASD versus 592 healthy controls [62].…”

Section: Ccl-11 In Autism Spectrum Disordermentioning

confidence: 99%

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders

et al. 2020

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Background: CCL-11 (eotaxin) is a chemokine with an important role in allergic conditions. Recent evidence indicates that CCL-11 plays a role in brain disorders as well. This paper reviews the associations between CCL-11 and aging, neurodegenerative, neuroinflammatory and neuropsychiatric disorders. Methods: Electronic databases were searched for original articles examining CCL-11 in neuropsychiatric disorders. Results: CCL-11 is rapidly transported from the blood to the brain through the blood-brain barrier. Age-related increases in CCL-11 are associated with cognitive impairments in executive functions and episodic and semantic memory, and therefore, this chemokine has been described as an “Endogenous Cognition Deteriorating Chemokine” (ECDC) or “Accelerated Brain-Aging Chemokine” (ABAC). In schizophrenia, increased CCL-11 is not only associated with impairments in cognitive functions, but also with key symptoms including formal thought disorders. Some patients with mood disorders and premenstrual syndrome show increased plasma CCL-11 levels. In diseases of old age, CCL-11 is associated with lowered neurogenesis and neurodegenerative processes, and as a consequence, increased CCL-11 increases risk towards Alzheimer’s disease. Polymorphisms in the CCL-11 gene are associated with stroke. Increased CCL-11 also plays a role in neuroinflammatory disease including multiple sclerosis. In animal models, neutralization of CCL-11 may protect against nigrostriatal neurodegeneration. Increased production of CCL-11 may be attenuated by glucocorticoids, minocycline, resveratrol and anti-CCL11 antibodies. Conclusions: Increased CCL-11 production during inflammatory conditions may play a role in human disease including age-related cognitive decline, schizophrenia, mood disorders and neurodegenerative disorders. Increased CCL-11 production is a new drug target in the treatment and prevention of those disorders.

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“…There are few studies that show high levels of CCL11 in ASD (Ashwood P et al 2006;Cunha et al 2015;Masi et al 2015). A meta-analysis reviewed the results of 17 ASD studies with a total sample size of 743 patients with ASD versus 592 healthy controls (Masi et al 2015).…”

Section: Ccl11 In Autism Spectrum Disorder (Asd)mentioning

confidence: 99%

“…59 (P. Ashwood et al 2006) 60 (Cunha GR et al, 2015) 61 (Masi et al, 2015) 62 (Zimmerman A et al, 2005) Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 30 January 2020 doi:10.20944/preprints202001.0370.v1…”

Section: Ocd (Obsessive Compulsive Disorder)mentioning

confidence: 99%

CCL11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-psychiatric Disorders

Ivanovska¹,

Abdi²,

Murdjeva³

et al. 2020

Preprint

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Background: CCL11 (eotaxin) is a chemokine with an important role in allergic conditions. Recent evidence indicates that CCL11 plays a role in brain disorders as well. Aims: This paper reviews the associations between CCL11 and aging, neurodegenerative, neuroinflammatory and neuropsychiatric disorders.Methods: Electronic databases were searched for original articles examining CCL11 in neuropsychiatric disorders.Results: CCL11 is rapidly transported from the blood to the brain through the brain-blood barrier. Age-related increases in CCL11 are associated with cognitive impairments in executive functions, episodic and semantic memory and, therefore, this chemokine was described as an “endogenous cognition deteriorating chemokine” (ECDC) or “accelerated brain-aging chemokine” (ABAC). In schizophrenia, increased CCL11 is not only associated with impairments in cognitive functions, but also with key symptoms including formal thought disorders. Some patients with mood disorders and premenstrual syndrome show increased plasma CCL11 levels. In diseases of old age, CCL11 is associated with lowered neurogenesis and neurodegenerative processes and, as a consequence, increased CCL11 increases risk towards Alzheimer's Disease. Polymorphisms in the CCL11 gene are associated with stroke. Increased CCL11 also plays a role in neuroinflammatory disease including multiple sclerosis. In animal models, neutralization of CCL11 may protect against nigrostriatal neurodegeneration. Increased production of CCL11 may be attenuated by glucocorticoids, minocycline, resveratrol and anti-CCL11 antibodies.Conclusion: Increased CCL11 production during inflammatory conditions may play a role in human disease including age-related cognitive decline, schizophrenia, mood disorders and neurodegenerative disorders. Increased CCL11 production is a new drug target in the treatment and prevention of those disorders.

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Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample

Cited by 9 publications

References 39 publications

Childhood adversity, mental health, and oxidative stress: A pilot study

Childhood adversity, mental health, and oxidative stress: A pilot study

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders

CCL11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-psychiatric Disorders

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