CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders

Ivanovska, Mariya; Abdi, Zakee; Murdjeva, Marianna; Macedo, Danielle; Maes, Annabel; Maes, Michael

doi:10.3390/ph13090230

Cited by 66 publications

(47 citation statements)

References 93 publications

(163 reference statements)

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“…CCL11, also known as eotaxin-1, is a chemokine that plays an important role in a variety of inflammatory conditions [39]. Although traditionally identified as an eosinophil chemoattractant, CCL11 can be secreted by lymphocytes, monocytes, endothelial cells, and other cells [40].…”

Section: Discussionmentioning

confidence: 99%

Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer’s disease

et al. 2021

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Background Accelerated long-term forgetting has been identified in preclinical Alzheimer’s disease (AD) and is attributed to a selective impairment of memory consolidation in which the hippocampus plays a key role. As blood may contain multiple senescence-related factors that involved in neurogenesis and synaptic plasticity in the hippocampus, we tested whether there is an association between blood-borne factors and accelerated long-term forgetting in asymptomatic individuals from families with autosomal dominant AD (ADAD). Methods We analyzed data of 39 asymptomatic participants (n = 18 ADAD mutation carriers, n = 21 non-carriers) from the Chinese Familial Alzheimer’s Disease Network (CFAN) study. Long-term forgetting rates were calculated based on recall or recognition of two materials (word list and complex figure) at three delays comprising immediate, 30 min, and 7 days. Peripheral blood concentrations of candidate pro-aging factors (CC chemokine ligand 11 [CCL11] and monocyte chemotactic protein 1 [MCP1]) and rejuvenation factors (growth differentiation factor 11 [GDF11], thrombospondin-4 [THBS4], and secreted protein acidic and rich in cysteine like 1 [SPARCL1]) were evaluated in all participants. Results Despite normal performance on standard 30-min delayed testing, mutation carriers exhibited accelerated forgetting of verbal and visual material over 7 days in comparison with matched non-carriers. In the whole sample, lower plasma THBS4 was associated with accelerated long-term forgetting in list recall (β = −0.46, p = 0.002), figure recall (β = −0.44, p = 0.004), and list recognition (β = −0.37, p = 0.010). Additionally, higher plasma GDF11 and CCL11 were both associated with accelerated long-term forgetting (GDF11 versus figure recall: β = 0.39, p = 0.007; CCL11 versus list recognition: β = 0.44, p = 0.002). Conclusions Accelerated long-term forgetting is a cognitive feature of presymptomatic AD. Senescence-related blood-borne factors, especially THBS4, GDF11, and CCL11, may be promising biomarkers for the prediction of accelerated long-term forgetting.

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Section: Discussionmentioning

confidence: 99%

Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer’s disease

et al. 2021

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“…Accumulating evidence indicates that increased level of pro-inflammatory chemokines: CCL2, CCL4, CCL11, CCL17, CCL22, and CCL24, in serum strongly correlates with schizophrenic symptoms including cognitive impairments in attention, working memory, episodic and semantic memory, and executive functions [ 11 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 ]. Several chemokines of CXC type (CXCL8, CXCL11, CXCL12), were also shown to act through PLC/Ca 2+ downstream signaling [ 269 , 270 , 271 ].…”

Section: Chemokine Receptorsmentioning

confidence: 99%

“…Moreover, the receptors can be differentially expressed in the CNS, making the separation of causes from the effects even more complicated. For example, there is an evidence that CCL-11 at low concentrations can act as a partial agonist at CCR2 and antagonize CCL2 activity, but high concentrations are sufficient to activate CCR2 in chemotaxis assays [ 261 , 274 ]. Some receptors have been proposed to form putative heteroreceptor complexes with an NMDA receptor (NMDAR-CCR2, NMDAR-CXCR4) that may also contribute to schizophrenia-like symptoms in mild neuroinflammation [ 275 ].…”

Section: Chemokine Receptorsmentioning

confidence: 99%

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The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines

Boczek

Mackiewicz

Sobolczyk

et al. 2021

Cells

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Schizophrenia is a common debilitating disease characterized by continuous or relapsing episodes of psychosis. Although the molecular mechanisms underlying this psychiatric illness remain incompletely understood, a growing body of clinical, pharmacological, and genetic evidence suggests that G protein-coupled receptors (GPCRs) play a critical role in disease development, progression, and treatment. This pivotal role is further highlighted by the fact that GPCRs are the most common targets for antipsychotic drugs. The GPCRs activation evokes slow synaptic transmission through several downstream pathways, many of them engaging intracellular Ca2+ mobilization. Dysfunctions of the neurotransmitter systems involving the action of GPCRs in the frontal and limbic-related regions are likely to underly the complex picture that includes the whole spectrum of positive and negative schizophrenia symptoms. Therefore, the progress in our understanding of GPCRs function in the control of brain cognitive functions is expected to open new avenues for selective drug development. In this paper, we review and synthesize the recent data regarding the contribution of neurotransmitter-GPCRs signaling to schizophrenia symptomology.

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“…Importantly, microglia and their effectors (e.g., chemokine CCL-11) are pivotal cellular mediators of neuroinflammation and can contribute to adult hippocampal neurogenesis as well as homeostatic synaptic pruning. Therefore, microglia are important cells in the clinical development of schizophrenia and psychosis 94,95 .…”

Section: Neurogenesis and Psychosismentioning

confidence: 99%

Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders

et al. 2021

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Psychiatric illness is a prevalent and highly debilitating disorder, and more than 50% of the general population in both middle- and high-income countries experience at least one psychiatric disorder at some point in their lives. As we continue to learn how pervasive psychiatric episodes are in society, we must acknowledge that psychiatric disorders are not solely relegated to a small group of predisposed individuals but rather occur in significant portions of all societal groups. Several distinct brain regions have been implicated in neuropsychiatric disease. These brain regions include corticolimbic structures, which regulate executive function and decision making (e.g., the prefrontal cortex), as well as striatal subregions known to control motivated behavior under normal and stressful conditions. Importantly, the corticolimbic neural circuitry includes the hippocampus, a critical brain structure that sends projections to both the cortex and striatum to coordinate learning, memory, and mood. In this review, we will discuss past and recent discoveries of how neurobiological processes in the hippocampus and corticolimbic structures work in concert to control executive function, memory, and mood in the context of mental disorders.

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CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders

Cited by 66 publications

References 93 publications

Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer’s disease

Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer’s disease

The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines

Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders

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