Predictors of in-hospital mortality in HIV-infected patients with COVID-19

Moreno-Torres, Víctor; Mendoza, Carmen de; Martínez-Urbistondo, María; Mills, Patricia; Treviño, Ana; Fuente, Sara de la; Santiago, Alberto Díaz de; Calderón-Parra, Jorge; Pintos-Pascual, Ilduara; Corpas, Manuel; Soriano, Vicente

doi:10.1093/qjmed/hcac215

Cited by 17 publications

(12 citation statements)

References 42 publications

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“…The prevalence of bacterial coinfection and superinfection during a COVID-19 infection is different than what we have experienced with prior viral pandemics (2)(3)(4). The majority of the current studies report a low prevalence of bacterial coinfection in hospitalized COVID-19 patients, ranging from 3.1% to 8.5%.…”

contrasting

confidence: 65%

Empiric Antibiotics in COVID-19 Patients: To Give or Not to Give*

Rimawi,

Almuti

2023

Critical Care Medicine

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contrasting

confidence: 65%

Empiric Antibiotics in COVID-19 Patients: To Give or Not to Give*

Rimawi,

Almuti

2023

Critical Care Medicine

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Section: Discussionmentioning

confidence: 99%

“…In this study, microbiological tests confirmed that about 1 quarter of COVID-19 patients had a 3-fold increase in bacterial infections compared to the results of other international studies. [16,17] A high prevalence of infection was secondary in 91% of cases, while the number of co-infections was rare. This is compatible with other studies where the prevalence was 3.5 and 14.3% for co-and secondary infections respectively.…”

Section: Discussionmentioning

confidence: 99%

The impact of COVID-19 pandemic on healthcare associated infections: A teaching hospital experience

et al. 2023

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Coronavirus disease-19 (COVID-19) is a global pandemic, with a high capability of contagious distribution, where national secondary and co-infections characterization are lacking. The objective of this study was to assess the impact of the COVID-19 pandemic on infection rates among patients admitted to the intensive care units at King Abdullah University Hospital, profiling the drug resistance rates nationally. This is a cross-sectional study of COVID-19 associated infections that was conducted at a teaching hospital, in the north of Jordan. It included all COVID-19 patients who were admitted to intensive care units during the first and second pandemic waves. Data on age, gender, length of stay, co-morbidities, co-infections and sensitivity to antibiotics were retrospectively collected from the hospital information database. Statistical analyses were performed using SPSS software. A total of 589 COVID-19 patients were included, of whom 20% developed bacterial associated infections. The ratio of bacterial co-infection to secondary infections was 1:8. Gram-negative bacteria, Acinetobacter baumannii (40.1%) , Eschericia coli (17.5%), Klebsiella pneumonia (6.8%), and Pseudomonas aeruginosa (5.1%) were the most abundant isolated species. The detection rates of E coli (ESBL), K pneumonia (ESBL), A baumannii (CRO), P aeruginosa (CRO), S aureus (MRSA) were 52%, 67%, 97%, 44%, and 67%, respectively.

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“…16,17 Baseline use of immunosuppressive medications have also been reported with an increased likelihood of secondary infection. 21 Finally, patients transferred from an outside facility were likely due to more severe COVID-19 because our institution serves as a referral center for the state of Oregon.…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for clinically confirmed secondary bacterial infections in patients hospitalized for coronavirus disease 2019 (COVID-19)

Park

McCracken

Lininger

et al. 2023

Infect. Control Hosp. Epidemiol.

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Objective: The true incidence and risk factors for secondary bacterial infections in coronavirus disease 2019 (COVID-19) remains poorly understood. Knowledge of risk factors for secondary infections in hospitalized patients with COVID-19 is necessary to optimally guide selective use of empiric antimicrobial therapy. Design: Single-center retrospective cohort study of symptomatic inpatients admitted for COVID-19 from April 15, 2020, through June 30, 2021. Setting: Academic quaternary-care referral center in Portland, Oregon. Patients: The study included patients who were 18 years or older with a positive severe acute respiratory coronavirus virus 2 (SARS-CoV-2) PCR test up to 10 days prior to admission. Methods: Secondary infections were identified based on clinical, radiographic, and microbiologic data. Logistic regression was used to identify risk factors for secondary infection. We also assessed mortality, length of stay, and empiric antibiotics among those with and without secondary infections. Results: We identified 118 patients for inclusion; 31 (26.3%) had either culture-proven or possible secondary infections among hospitalized patients with COVID-19. Mortality was higher among patients with secondary infections (35.5%) compared to those without secondary infection (4.6%). Empiric antibiotic use on admission was high in both the secondary and no secondary infection groups at 71.0% and 48.3%, respectively. Conclusions: The incidence of secondary bacterial infection was moderate among hospitalized patients with COVID-19. However, a higher proportion of patients received empiric antibiotics regardless of an identifiable secondary infection. Transfer from an outside hospital, baseline immunosuppressant use, and corticosteroid treatment were independent risk factors for secondary infection. Additional studies are needed to validate risk factors and best guide antimicrobial stewardship efforts.

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Predictors of in-hospital mortality in HIV-infected patients with COVID-19

Cited by 17 publications

References 42 publications

Empiric Antibiotics in COVID-19 Patients: To Give or Not to Give*

Empiric Antibiotics in COVID-19 Patients: To Give or Not to Give*

The impact of COVID-19 pandemic on healthcare associated infections: A teaching hospital experience

Incidence and risk factors for clinically confirmed secondary bacterial infections in patients hospitalized for coronavirus disease 2019 (COVID-19)

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