Predictors of Failure after Pancreaticoduodenectomy for Ampullary Carcinoma

Kim, Robin D.; Kundhal, Pavi S.; McGilvray, Ian; Cattral, Mark S.; Taylor, Bryce; Langer, Bernard; Grant, David; Zogopoulos, George; Shah, Shimul A.; Greig, Paul D.; Gallinger, Steven

doi:10.1016/j.jamcollsurg.2005.08.002

Cited by 91 publications

(73 citation statements)

References 38 publications

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“…The incidence of ampullary carcinoma is estimated to be 5-7 cases per 1,000,000 person-years at-risk, accounting for 0.2% of gastrointestinal tract cancers [1,2,3]. A number of recent reports have documented 5-year survival rates ranging from 34% to 67.7% [2,4,5,6].…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing Lymph Node Metastasis in Patients with Ampullary Adenocarcinoma

Okano

Asano

Kushida³

et al. 2014

Dig Surg

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Aim: In cases of ampullary carcinoma, lymph node involvement affects the selection of treatment strategies. This study aimed to identify clinicopathologic features of ampullary carcinoma with lymph node metastases. Methods: The records of 74 consecutive patients with ampullary adenocarcinoma who underwent pancreaticoduodenectomy (PD) with regional lymph node dissection were retrospectively analyzed. Results: Twenty-two patients (30%) with lymph node metastasis had significantly worse survival after resection than those without lymph node metastasis (p = 0.017). Univariate analyses revealed that preoperative biliary drainage; elevated serum carbohydrate antigen 19-9 (≥36 U/ml); moderate-to-poor pathologic grade (G2/3); perineural, vascular, lymphatic, pancreas, and duodenal invasion; and T category were significantly associated with lymph node metastasis. In multivariate analysis, only pathologic grade (G2/3) remained significantly associated with lymph node metastasis (hazard ratio, 6.51; p = 0.035). In sub-classified analysis for T category, lymph node metastasis was found in 5 of 22 cases (22.7%) of T1 tumors. Four of five cases with lymph node metastases had a dominant G2/3 component, whereas only 2 of 17 cases without lymph node metastases had a G2/3 component in T1 tumors (p = 0.0036). Conclusions: Pathologic grade (G2/3) was significantly and independently associated with lymph node metastasis and was also a significant predictor in T1 tumor cases.

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Section: Introductionmentioning

confidence: 99%

Factors Influencing Lymph Node Metastasis in Patients with Ampullary Adenocarcinoma

Okano

Asano

Kushida³

et al. 2014

Dig Surg

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“…In humans, this is an uncommon tumor arising from the epithelium of the common bile duct or the major pancreatic duct and accounts for only 0.2% of all intestinal tumors (5). Patients commonly present with jaundice and weight loss (11). LN metastases is an important predictor for survival and is noted in 50% of human cases at the time of diagnosis (1,5), but the liver is the most common site of distant metastases (1).…”

Section: Discussionmentioning

confidence: 99%

The Incidence of Spontaneous Neoplasia in Two Populations of Captive Rhesus Macaques (Macaca mulatta)

Simmons

Mattison

2011

Antioxidants & Redox Signaling

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Rhesus macaques (Macaca mulatta) are genetically similar to humans and share many characteristics of aging and age-related diseases. They age at approximately three times the rate of humans and develop spontaneous cancers. In both humans and rhesus macaques, cancer incidence increases with age with the greatest incidence in those over 60 years of age and 20 years, respectively. The current survey reports on the incidence of spontaneous neoplasia in two colonies of captive rhesus macaques: the Wisconsin National Primate Research Center colony with 28 years of records and a National Institute on Aging colony with 21 years of records. When categorized by organ and histologic diagnosis, the average age at diagnosis was greater than 20 years for all categories except oral squamous cell carcinoma. Neoplasms of the gastrointestinal system were the most commonly diagnosed, accounting for 48.8% of the cases. Adenocarcinomas of the large intestine were the most prevalent tumor identified. Although there are differences in the biological behavior of cancer in the rhesus macaque when compared with humans, they are a valuable model of comparative oncology. Antioxid. Redox Signal. 14, 221-227.

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“…Liver metastases after the primary surgery occurred in 9-45% of extrahepatic BDC [4][5][6][7][8][9] and 10-41% of PVC cases [8][9][10][11][12]. Hsu et al [10] reported that positive nodal metastasis was a single risk factor for liver metastasis in PVC.…”

Section: Discussionmentioning

confidence: 99%

Hepatic resection for liver metastases from carcinomas of the distal bile duct and of the papilla of Vater

Kurosaki

Minagawa

Kitami

et al. 2011

Langenbecks Arch Surg

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Predictors of Failure after Pancreaticoduodenectomy for Ampullary Carcinoma

Cited by 91 publications

References 38 publications

Factors Influencing Lymph Node Metastasis in Patients with Ampullary Adenocarcinoma

Factors Influencing Lymph Node Metastasis in Patients with Ampullary Adenocarcinoma

The Incidence of Spontaneous Neoplasia in Two Populations of Captive Rhesus Macaques (Macaca mulatta)

Hepatic resection for liver metastases from carcinomas of the distal bile duct and of the papilla of Vater

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