Predictors of Event-Driven Regimen Choice in Current PrEP Users and Sexual Behavior Characteristics of MSM Receiving Sexual Health Services in New York City

Incorrect Knowledge of Event-Driven PrEP “2-1-1” Dosing Regimen Among PrEP-Experienced Gay and Bisexual Men in Australia

“…Although awareness of ED-PrEP is not well documented internationally, our results are similar to previous studies that reported one-third to one-half of participants having heard of ED-PrEP. 11,15 GBM who do not find daily PrEP suitable for their HIV prevention needs could potentially benefit from taking ED-PrEP but may simply be unaware of this regimen. Previous work on PrEP cascades, which identified steps that might have prevented eligible GBM from using PrEP, found that awareness of PrEP was the main barrier to PrEP uptake during early PrEP rollout.…”

“…However, awareness of ED-PrEP does not necessarily lead to greater uptake of this regimen because individuals may simply prefer daily PrEP or not to take PrEP at all. 15 Regardless, ED-PrEP has the potential to increase overall PrEP coverage because daily PrEP may not be suitable for all GBM at risk of HIV, and ED-PrEP could also offer ways to address the reasons why GBM discontinue daily PrEP after initiation. These include cost, side effects, or perceived low self-efficacy to adhere to daily pill taking, 17,[31][32][33][34] and these reasons can also prevent GBM from initiating daily PrEP.…”

“…Previous research has indicated that a substantial minority of GBM would prefer ED-PrEP to daily dosing. 5,[11][12][13][14][15] Common reasons for preferring ED-PrEP over daily PrEP among GBM include the convenience of taking fewer pills, the likelihood of fewer side effects, and lower cost of ongoing medication. 5,11,13,15 Individuals who have infrequent sex or can anticipate when they will have sex have also found ED-PrEP preferable.…”

“…5,[11][12][13][14][15] Common reasons for preferring ED-PrEP over daily PrEP among GBM include the convenience of taking fewer pills, the likelihood of fewer side effects, and lower cost of ongoing medication. 5,11,13,15 Individuals who have infrequent sex or can anticipate when they will have sex have also found ED-PrEP preferable. 5,11,16,17 Conversely, common reasons expressed by PrEP users for preferring daily PrEP over ED-PrEP include feeling greater control, being protected from HIV during more spontaneous sexual encounters, and perceived lower efficacy of ED-PrEP.…”

Implementation of HIV Preexposure Prophylaxis in Diverse, Real-World Settings

“…In some studies that examined attitudes toward PrEP, participants indicated that ED-PrEP was an attractive alternative for them owing to cost concerns or adverse effects of D-PrEP. 4,5 However, there is a paucity of real-world data available about ED-PrEP efficacy, because most of the data thus far have been generated from studies in Europe or North America. 4,6,7 Studies have shown that ED-PrEP is highly efficacious in preventing HIV in clinical trials and some cohorts, but realworld experience from diverse populations and settings is necessary.…”