Predictors of early distant metastasis in women with breast cancer

E, Mendoza; Moreno, Emmanuel Martínez; Caguioa, Priscilla B.

doi:10.1007/s00432-012-1367-z

Cited by 48 publications

(45 citation statements)

References 16 publications

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“…In a study by Erick Sta et al which focused on factors effective in less than 2-year recurrence, the major factors effective in early recurrence were tumor stage, and size and lymph node status. This study showed that her2 receptor overexpression was not the only determining factor, but triple negative breast cancer patients were likely to experience early metastasis (9).…”

Section: Discussionmentioning

confidence: 75%

“…Breast cancer patients are at recurrence risk even years after receiving treatment which is the highest during the 2 -3 years after detection of the primary tumor (9). Distant metastasis is the most prevalent form of recurrence and the main cause of death in breast cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…Also, 50% of patients suffer from late recurrence after 5 years (9). Thanks to advancements in early detection and breast cancer treatments, long time survival is expected and in turn it will be of great interest for researchers (10).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic Factors of Recurrence (Early and Late) and Death in Breast Cancer Patients in Iranian Women

Akbari

Nafissi

et al. 2016

Iran J Cancer Prev

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show abstract

Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic Factors of Recurrence (Early and Late) and Death in Breast Cancer Patients in Iranian Women

Akbari

Nafissi

et al. 2016

Iran J Cancer Prev

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show abstract

“…Studies revealing a similar correlation in other tumor types have delivered conflicting results: For example, in a breast cancer study, a positive correlation between the age and visceral metastases was identified (31). In another study on melanoma, the prognosis worsened with age, whereas the number of CD168-positive sentinel nodes decreased (32).…”

Section: Discussionmentioning

confidence: 99%

Expression patterns of CD168 correlate with the stage and grade of squamous cell carcinoma of head and neck

Jöhrens

Anagnostopoulos

Dommerich

et al. 2017

Molecular and Clinical Oncology

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Abstract. The receptor for hyaluronan-mediated motility CD168 is associated with the processes of oncogenesis and metastasis. The objective of the present study was to determine the possible association between the expression and distribution of CD168 and the tumor stage of head-and-neck squamous cell carcinoma (SCC). Formalin-fixed and paraffinembedded tumor samples obtained from 100 patients during primary resection of SCC from the oral cavity, oropharynx, hypopharynx or larynx were included in the present study. The patients were divided into two risk groups: Low risk, representing the early stage of completely resected SCCs with good-to-moderate differentiation, and the high-risk group, representing the advanced stage SCCs with positive resection margins, vascular invasion or locoregional metastasis. All specimens were stained with a monoclonal antibody against CD168. Percentage and staining intensity of CD168-positive cells were scored, and their spatial distribution within the tumor nests was noted. The results obtained were correlated with the tumor stage. The quantification of CD168 expression revealed significant differences between the two risk groups (t-test, P=0.002), with higher scores in tumors resected from the highrisk SSC group compared with those from the low-risk group. In addition, in the high-risk group, the CD168-positive cells were present predominantly in the periphery (70.4%) of tumor nests, whereas in the low-risk group, only 56.6% were located there; however, this trend did not reach the level of statistical significance. Taken together, the results from the present study suggested that CD168 expression patterns could potentially be used as a predictor of tumor aggressiveness, and therefore they may be a prognostic factor in head-and-neck SCC.

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“…About 10% to 15% of breast cancer patients have distant metastases within 2 years, which significantly reduced the 5 year survival rate [1]. Staging, Tumor size and lymph node metastasis are important prognostic factors for breast cancer metastasis, and in those factors, lymph node metastasis is the most important effect on ductal breast cancer prognosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical Pathological Analysis in 104 Ductal Breast Cancer Cases

Jin¹,

Huang²,

Li³

et al. 2017

JBM

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Ductal breast cancer is a clinically heterogeneous disease; we investigate the correlation between tumor size, comedo necrosis, number of cell mitoses and axillary lymph node metastasis in ductal breast cancer. In this study, 104 ductal breast cancer specimens were collected and divided into 3 groups: T1 group (tumor size ≤ 2 cm), T2 group (2 < tumor size ≤ 5 cm) and T3 group (tumor size > 5.0 cm). Among those specimens, 95 cases were diagnosed with invasive ducted carcinoma, and 9 cases were ductal carcinoma in-situ (DCIS).Results show that T3 group has a higher rate of axillary lymph node metastasis than T2 group and T1 group; T2 group has a higher rate of lymph node metastasis than T1 group. The patients with the number of cell mitoses (≥10) were also has a higher rate of axillary lymph node metastasis (P = 0.0139) than the patients with the number of cell mitoses (<10). No significance was found between comedo necrosis lesions and axillary lymph node metastasis, though the frequency of comedo necrosis lesions in patients with axillary lymph node metastasis was higher than those in non-metastatic patients. It is concluded that the tumor size and the number of cell mitoses were risk factors for axillary lymph node involvement in ductal breast cancer.

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Predictors of early distant metastasis in women with breast cancer

Cited by 48 publications

References 16 publications

Prognostic Factors of Recurrence (Early and Late) and Death in Breast Cancer Patients in Iranian Women

Prognostic Factors of Recurrence (Early and Late) and Death in Breast Cancer Patients in Iranian Women

Expression patterns of CD168 correlate with the stage and grade of squamous cell carcinoma of head and neck

Clinical Pathological Analysis in 104 Ductal Breast Cancer Cases

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