Predictors of early death in a cohort of Ethiopian patients treated with HAART

Abstract

Background: HAART has improved the survival of HIV infected patients. However, compared to patients in high-income countries, patients in resource-poor countries have higher mortality rates. Our objective was to identify independent risk factors for death in Ethiopian patients treated with HAART.

Survival and Predictors of Mortality among Adults on Antiretroviral Therapy in Selected Public Hospitals in Harar, Eastern Ethiopia

“…This higher mortality rate was similar with studies conducted in different Africa countries [5,7,[9][10][11][12][13]. The early deaths may reflect the late initiation of ART with the advanced clinical stage and severely compromised status of CD4 cell counts (<50 cells/ µl).…”

“…Hence, Successful implementation of such initiatives needs scientific evidence generated in the appropriate settings [7].…”

Determination of Predictors Associated With HIV/AIDS Patients on ART Using Accelerated Failure Time Model for Interval Censored Survival Data

“…The studies from limited setting also reported similar results (Jerene et al, 2006). Van der Sande et al (2004) had advocated that BMI at the time of HIV diagnosis is a strong and independent predictor of survival.…”

“…To our knowledge hemoglobin has never shown to predict mortality of patients on ART in India, further studies are needed to confirm our findings. Baseline hemoglobin level can be used as a simple and practical tool for initial risk assessment in the absence of CD4 cell count and viral load, as was identified in earlier studies by Johannessen et al (2008) in Tanzania, Jerene et al (2006) in Ethopia and Mocroft et al (1999) in Europe.…”

“…There are several studies which describes the estimation of survival of HIV populations and underlying covariates effect on hazard of death among HIV patients on ART by using Cox proportional hazard model for right censored data in India and resource limited setting countries (Ghate et al, 2011;Rai et al, 2013;Kee et al, 2009;Jerene et al, 2006). However, no one has tried to identify the significant predictor associated with the survival of HIV/AIDS patients undergoing ART using parametric AFT Model under interval censored set up.…”