Predictors of complications and of unfavorable outcomes in myocardial infarction

Бобровская, Е. Е.; Бурова, Н Н; Kon, Valentina

doi:10.18705/1607-419x-2009-15-5-539-542

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…В то же время высокие уровни NT-proBNP и Ptx-3 (p<0,05) увеличивали риск смертельного исхода через 1 год. Помимо данных факторов, ФР развития ССО были низкое диастолическое АД, желудочковая тахикардия при поступлении в стационар, высокие уровни AсАT и другие параметры, имеющие подтверждение в источниках литературы [18].…”

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Multifactor predictive model in patients with myocardial infarction based on modern biomarkers

et al. 2020

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Objective To study the prognostic role of current serum biomarkers in patients with myocardial infarction (MI) by constructing a multifactorial model for prediction of cardiovascular complications (CVC) in remote MI. Acute coronary syndrome is a major cause of death and disability in the Russian Federation. Introduction of current biomarkers, such as N-terminal pro-brain natriuretic peptide, stimulating growth factor (ST2), and centraxin-2 (Pentraxin, Ptx-3), provides more possibilities for diagnostics and calculation of risk for CVC.Materials and Methods Concentrations of biomarkers were measured in 180 patients with MI (mean age, 61.4±1.7) upon admission. At one year, specific and composite endpoints were determined (MI, acute cerebrovascular disease, admission for CVD, and cardiovascular death). Based on this information, a prognostic model for subsequent events was developed.Results A mathematical model was created for computing the development of a composite endpoint. In this model, the biomarkers NT-proBNP, Ptx-3 and, to a lesser extent, ST2 demonstrated their prognostic significance in diagnosis of CVC with a sensitivity of 78.79 % and specificity of 86.67 % (area under the curve, AUC 0.73).Conclusion In patients with remote MI, the biomarkers NT-proBNP, ST2, and Ptx-3 improve prediction of CVC.

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Multifactor predictive model in patients with myocardial infarction based on modern biomarkers

et al. 2020

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Changes in pattern of complications in acute myocardial infarction over a ten-year follow-up: gender specificities

Округин

Репин

2020

Cardiovasc Ther Prev

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Aim. To compare changes in pattern of complications in acute myocardial infarction (MI) among Tomsk population at the age of >20 years over a ten-year follow-up period (2008-2017).Material and methods. The study was carried out on the basis of the World Health Organization Acute Myocardial Infarction Registry. In 2008, 800 MI cases were recorded (62,4% — men; 37,6% — women (p<0,001)). In 2017, acute MI was restarted in 906 patients (58,1% — men; 41,9% — women (p<0,05)). According to age pattern in 2008, there were 62,1% of patients >60 years of age (among men — 49,1%; among women — 83,7% (p<0,0001)), which after 10 years were 74,5 % (p<0,001).Results. In 2008, a complicated course of MI was observed in 49,9% of patients, in 2017, much more often — in 80,4% of patients (p<0,001). Over the analyzed period, incidence of acute aneurysm, myocardial rupture, and recurrent MI decreased. At the same time, the number of patients with post-MI heart failure (HF) significantly increased. In 2008, there were no significant differences in the incidence of MI complications in men and women. The most common complication in both men and women was arrhythmias and conduction disorders. After 10 years, the statistics remained virtually unchanged, with the exception of pulmonary embolism, which was significantly more common in women. Noteworthy is a significant increase in the number of HF patients (among men and women).Conclusion. Over a ten-year follow-up period, significant changes in patterns of MI complications in Tomsk were not revealed. It should be noted that MI became more severe and was more often accompanied by complications, the most common of which was HF. This is due to an increase in the age pattern of elderly and senile patients.

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Analysis of the outcomes of myocardial infarction against the background of chronic obstructive pulmonary disease among residents of the Astrakhan region

Prokof'eva,

Polunina,

Polunina

et al. 2023

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Objective. To analyse the course of coronary heart disease within a year after the development of myocardial infarction in residents of Astrakhan region with chronic obstructive pulmonary disease. Materials and Methods. We examined 325 patients with myocardial infarction, residents of Astrakhan region. 195 patients had heart attacks against the background of COPD and 130 patients without COPD. During 12-month follow-up 30 people dropped out - 19 in the group of patients with myocardial infarction against COPD, 11 in the group of patients with myocardial infarction without COPD. Correspondingly, by the end of the observation period the number of patients under observation was: 176 - in the group of patients with myocardial infarction against COPD, and 119 - in the group of patients with myocardial infarction without COPD. Results. It was found that in patients with myocardial infarction against COPD the annual mortality from conditions associated with cardiovascular pathology was twice as frequent as in patients with MI without COPD. There was also a tendency to more frequent development of recurrent myocardial infarction. In the structure of mortality in patients with myocardial infarction against COPD and without COPD and there was a tendency to a more frequent occurrence of acute heart failure expressed stages (Killip III-IV) and decompensation of chronic heart failure as causes of mortality. The odds of developing a combined endpoint, including recurrent myocardial infarction, stroke and mortality from cardiac causes, among patients with myocardial infarction against COPD were 2.7 times higher compared to patients with myocardial infarction without COPD. The combined endpoint, which combines clinically significant events in patients with myocardial infarction, makes the existing differences in the outcomes of infarction in patients with and without COPD evident.

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Predictors of complications and of unfavorable outcomes in myocardial infarction

Cited by 3 publications

References 26 publications

Multifactor predictive model in patients with myocardial infarction based on modern biomarkers

Multifactor predictive model in patients with myocardial infarction based on modern biomarkers

Changes in pattern of complications in acute myocardial infarction over a ten-year follow-up: gender specificities

Analysis of the outcomes of myocardial infarction against the background of chronic obstructive pulmonary disease among residents of the Astrakhan region

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