Predictors of atopic dermatitis phenotypes and severity: Roles of serum immunoglobulins and filaggrin gene mutation R501X

Abstract

In a sample of Turkish children, FLG R501X genotyping revealed no risk alleles in variable severities of AD or healthy controls. Our data suggest that IgG and IgA levels might have a role in phenotypic features of AD in terms of severity and atopic sensitisation.

Filaggrin loss-of-function mutations as a predictor for atopic eczema, allergic sensitization and eczema-associated asthma in Polish children population

“…8,9 To date, there have been only 2 published studies that did not shown an association between FLG null mutations and atopic eczema. 19,20 Our observation that eczema patients carrying FLG mutation were younger at the onset of eczema than those without FLG mutations are in agreement with previous studies indicating that FLG mutations have the effect on the age of onset of atopic eczema and can lead to earlyonset that persists well into adulthood. 21,22 Further observations will be helpful in determining the effect of FLG mutations on the persistence of disease in our population.…”

“…Previous studies showing a positive association between FLG null mutations and atopic eczema have focused on moderate-or-severe eczema cases recruited from specialist clinics and on children with eczema as part of atopy-related birth cohort studies. 3,10,18,20,22,23 It is possible that an association existed in Polish children with moderate-severe atopic eczema but unfortunately most of our participants have mild (62%) or moderate (38%) eczema. On the other hand, few studies reported that there was no association between FLG mutations and the severity of atopic eczema like our results.…”

Rare occurrence of common filaggrin mutations in Turkish children with food allergy and atopic dermatitis

“…Paralleling the Italian study, a study including Egyptian patients showed no association of R501X and 2282del4 mutations with AD [35]. To our knowledge, the association between LOF mutations and AD in a Turkish population was investigated in only one prior study, and no association was found between the R501X mutation and Turkish children with AD [36].…”

Staphylococcal enterotoxin B induces specific IgG4 and IgE antibody serum levels in atopic dermatitis

“…19 Other data indicate that in severe AD, the levels of IgA and IgG are higher and may have an effect on AD phenotype and atopy onset. 21 The purpose of our study was to evaluate the involvement of immunoglobulins (A, M, G, E) and IgG subclasses in the anti-Staphylococcus aureus enterotoxin B (SEB) immune response in AD and their relation with disease severity.…”