Staphylococcal enterotoxin B induces specific IgG4 and IgE antibody serum levels in atopic dermatitis

Orfali, Raquel Leão; Sato, Maria Notomi; Santos, Vanessa G.; Titz, Tiago O.; Brito, Cyro Alves de; Duarte, Alberto J. S.; Takaoka, Roberto; Aoki, Valéria

doi:10.1111/ijd.12533

Cited by 26 publications

(18 citation statements)

References 40 publications

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“…As a serious global public health problem [1], the morbidity of AD has increased in recent years [2]. AD is a disease arising from complex interaction of genetic factors with skin barrier dysfunction and environmental factors [3,4].…”

Section: Introductionmentioning

confidence: 99%

Sea Buckthorn (Hippophaë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF-κB and STAT1 Activation

Hou

Di²,

Qi³

et al. 2017

Skin Pharmacol Physiol

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Background and Objectives: The objective of this study was to evaluate the topical effects of sea buckthorn (SBT) oil on atopic dermatitis (AD)-like lesions in a mouse model generated by repeated topical administration of DNCB in BALB/c mice. Methods: DNCB was applied repeatedly on the dorsal skin of mice to induce AD-like lesions. Following AD induction, SBT oil was applied daily on the dorsal skin for 4 weeks. The severity of skin lesions was examined macroscopically and histologically. We further measured the production of MDC/CCL22 and TARC/CCL17 in IFN-γ/TNF-α activated HaCaT cells. Results: Topically applied SBT oil in DNCB-treated mice ameliorated the severity score of dermatitis, decreased epidermal thickness, reduced spleen and lymph node weights, and prevented mast cell infiltration. In addition, SBT oil suppressed the Th2 chemokines TARC and MDC via dose-dependent inhibition of NF-κB, JAK2/STAT1, and p38-MAPK signaling pathways in IFN-γ/TNF-α-activated HaCaT cells. Conclusion: These results suggest that SBT oil had a beneficial effect on AD-like skin lesions, partially via inhibition of the Th2 chemokines TARC and MDC in inflamed skin.

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Section: Introductionmentioning

confidence: 99%

Sea Buckthorn (Hippophaë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF-κB and STAT1 Activation

Hou

Di²,

Qi³

et al. 2017

Skin Pharmacol Physiol

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“…SE sensitization is strongly associated with eczema and skin colonization . However, any causality needs to be confirmed in a longitudinal study.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus enterotoxin sensitization is associated with allergic poly‐sensitization and allergic multimorbidity in adolescents

Sørensen

Klingenberg

Wickman

et al. 2017

Allergy

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“…27 Orfali et al have indicated that Staphylococcus aureus is present in 80%-100% of skin samples from atopic patients and is related to worsening of the disease by the action of enterotoxins. 28 Our previous work has indicated that SEB acts as an adjuvant in the development of a food allergy mouse model. 14 We have also found that SEB is decomposed into small peptides in the digestive tracts of patients with food allergies, and then the SEB peptides act as haptens, facilitating the development of food allergies.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of squamous cancer growth in a mouse model by Staphylococcal enterotoxin B-triggered Th9 cell expansion

et al. 2015

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Currently, therapy for squamous cancer (SqC) is unsatisfactory. Staphylococcal enterotoxin B (SEB) has strong immune regulatory activity. This study tests the hypothesis that SEB enforces the effect of immunotherapy on SqC growth in a mouse model. C3H/HeN mice and the SqC cell line squamous cell carcinoma VII were used to create an SqC mouse model. Immune cell assessment was performed by flow cytometry. Real-time RT-PCR and western blotting were used to evaluate target molecule expression. An apoptosis assay was used to assess the suppressive effect of T helper-9 (Th9) cells on the SqC cells. The results showed that immunotherapy consisting of SEB plus SqC antigen significantly inhibited SqC growth in the mice. The frequency of Th9 cells was markedly increased in the SqC tissue and mouse spleens after treatment. SEB markedly increased the levels of signal transducer and activator of transcription 5 phosphorylation and the expression of histone deacetylase-1 (HDAC1) and PU.1 (the transcription factor of the interleukin 9 (IL-9) gene) in CD4 T cells. Exposure to SqC-specific Th9 cells markedly induced SqC cell apoptosis both in vitro and in vivo. In conclusion, the administration of SEB induces Th9 cells in SqC-bearing mice, and theseTh9 cells inhibit SqC growth.

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Staphylococcal enterotoxin B induces specific IgG4 and IgE antibody serum levels in atopic dermatitis

Abstract: Our findings evidenced a contributing role for IgG4 and IgE antibodies in AD pathogenesis, which are triggered by staphylococcal superantigens.

Cited by 26 publications

References 40 publications

Sea Buckthorn (Hippophaë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF-κB and STAT1 Activation

Sea Buckthorn (Hippophaë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF-κB and STAT1 Activation

Staphylococcus aureus enterotoxin sensitization is associated with allergic poly‐sensitization and allergic multimorbidity in adolescents

Inhibition of squamous cancer growth in a mouse model by Staphylococcal enterotoxin B-triggered Th9 cell expansion

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Staphylococcal enterotoxin B induces specific IgG4 and IgE antibody serum levels in atopic dermatitis

Abstract: Our findings evidenced a contributing role for IgG4 and IgE antibodies in AD pathogenesis, which are triggered by staphylococcal superantigens.

Cited by 26 publications

References 40 publications

Sea Buckthorn (Hippophaë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF-&#x03BA;B and STAT1 Activation

Sea Buckthorn (Hippophaë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF-&#x03BA;B and STAT1 Activation

Staphylococcus aureus enterotoxin sensitization is associated with allergic poly‐sensitization and allergic multimorbidity in adolescents

Inhibition of squamous cancer growth in a mouse model by Staphylococcal enterotoxin B-triggered Th9 cell expansion

Contact Info

Product

Resources

About

Sea Buckthorn (Hippophaë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF-κB and STAT1 Activation

Sea Buckthorn (Hippophaë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF-κB and STAT1 Activation