Predictors of and Factors Associated with Novel Post COVID Symptoms in the Musculoskeletal, Functional, and Cognitive Domains for Vaccinated Delta-Variant Survivors: A Descriptive Survey of a Nationwide Prospective Inception Cohort in Bangladesh

Chakrovorty, Sonjit Kumar; Hossain, K M Amran; Hossain, Mohammad Anwar; Ahammad, Shameem; Kabir, Md. Feroz; Shafin, Rubayet; Sivan, Manoj; Mamun, Mohammed A.; Al‐Mamun, Firoj; Jahid, Iqbal Kabir

doi:10.2139/ssrn.4249920

Cited by 6 publications

(14 citation statements)

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“…In Bangladesh, studies estimate that between 16 and 24% of those recovering from COVID-19 infection face long COVID [ 2 , 4 ]. The long COVID has a wide prevalence rate globally, ranging from 7 to 43% [ 2 – 4 ], and pain is one of the major long COVID symptoms [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical presentation of post-COVID pain and its impact on quality of life in long COVID patients: a cross-sectional household survey of SARS-CoV-2 cases in Bangladesh

Kabir,

Yin,

Jeffree

et al. 2024

BMC Infect Dis

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Background Pain is one of the prevalent Long COVID Symptoms (LCS). Pain interferes with the quality of life (QoL) and induces disease burden. Purpose The study aimed to elicit the clinical presentation of pain and determine the relationships between QoL and pain in LCS. Methods This household cross-sectional study of 12,925 SARS-CoV-2 cases between July and December 2021 was carried out in eight administrative divisions of Bangladesh. Stratified random sampling from the cases retrieved from the Ministry of Health was employed. Symptom screening was performed through COVID-19 Yorkshire Rehabilitation Scale, and long COVID was diagnosed according to World Health Organization (WHO) criteria. The analyses were conducted using IBM SPSS (Version 20.00). Results The prevalence of pain in long COVID was between 01 and 3.1% in the studied population. The study also found five categories of pain symptoms as LCS in Bangladesh: muscle pain 3.1% (95% CI; 2.4–3.8), chest pain 2.4% (95% CI; 1.8–3.1), joint pain 2.8% (95% CI; 2.2–2.3), headache 3.1% (95% CI; 2.4–3.8), and abdominal pain 0.3% (95% CI; 0.01–0.5). People with LCS as pain, multiple LCS, and longer duration of LCS had significantly lower quality of life across all domains of the WHOQOL-BREF (P < 0.001) compared to asymptomatic cases. Conclusion Three out of ten people with long COVID experience painful symptoms, which can significantly reduce their quality of life. Comprehensive rehabilitation can improve the symptoms and reduce the burden of the disease.

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Section: Introductionmentioning

confidence: 99%

Clinical presentation of post-COVID pain and its impact on quality of life in long COVID patients: a cross-sectional household survey of SARS-CoV-2 cases in Bangladesh

Kabir,

Yin,

Jeffree

et al. 2024

BMC Infect Dis

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“…The global prevalence of Long COVID (LC) survivors varies between 10 to 36% [ 2 ]. A household survey reported the prevalence of LC in Bangladesh was 16.1% as of 2020 [ 3 ] and the rate increased to 25.2% in another survey [ 4 ]. A variety of symptoms were reported in both studies with major symptoms which included fatigue, musculoskeletal pain, headache, loss of concentration, anxiety, depression, and post-exertion dyspnea [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…A household survey reported the prevalence of LC in Bangladesh was 16.1% as of 2020 [ 3 ] and the rate increased to 25.2% in another survey [ 4 ]. A variety of symptoms were reported in both studies with major symptoms which included fatigue, musculoskeletal pain, headache, loss of concentration, anxiety, depression, and post-exertion dyspnea [ 3 , 4 ]. LC is not only a sequel of COVID-19, but also it has an unpredictable disease course that is evident to be extended to more than a year, and a variety of symptoms are prevalent with the changing of time [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Profile of long COVID symptoms needing rehabilitation: a cross-sectional household survey of 12,925 SARS-CoV-2 cases between July and December 2021 in Bangladesh

et al. 2023

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Background and aims : It is important to determine the profile of long COVID (LC) symptoms within the scope of rehabilitation in Bangladesh. This study’s objective was to estimate the newly experienced long COVID symptoms needing rehabilitation by determining the prevalence and spectrum of impairments due to LC in Bangladesh. Methods A Cross-sectional household survey of 12,925 COVID-19 patients confirmed by RT-PCR from 24 testing facilities in Bangladesh. LC was diagnosed according to WHO working group definition. COVID-19 Yorkshire Rehabilitation Scale (C19-YRS) was used to determine the symptom responses, symptom severity, new long COVID symptoms, and scope of rehabilitation. Results The population proportion of LC symptoms requiring rehabilitation interventions are 0.22 [95% CI, 0.20–0.24] in Bangladeshi people diagnosed with SARS-CoV-2. Among them, 0.08 [95% CI, 0.07–0.09] had mild, 0.07 [95% CI, 0.06–0.09] had moderate, and 0.05 [95% CI, 0.04–0.06] had severe long COVID symptoms (LCS). There was a significant positive correlation between LCS and functional disabilities (r = 0.889, p < 0.001), while a negative correlation was observed between the severity of symptoms and overall health (r=-0.658, p < 0.001). In comparison to the pre-COVID status, 17 new LCS were observed and the increase in the scope of rehabilitation intervention among LCS ranged between 0.01 [95% CI, 0.001–0.01] and 0.21 [95% CI, 0.19–0.22]. In Bangladesh, 59% (n = 334) of the LC cases are out of reach for any rehabilitation interventions. Conclusion Nearly one-fourth of Bangladeshi Post-COVID-19 have long COVID (LC). Seventeen symptoms (LCS) were observed and more than half of the populations having long COVID are out of reach of any rehabilitation facilities.

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“…1 Between 16.2% and 25.2% of Bangladeshi people are experiencing LCS. 2,3 The respondents reported a broad spectrum of LCS, those were reported as fatigue, musculoskeletal pain, headache, loss of concentration, anxiety, depression, and post-exertion dyspnea. The presentation of LCS was noted as a relapsing remittent nature, which might not be described as related to a single biological system or organ involvement in the human body.…”

Section: Introductionmentioning

confidence: 99%

“…6 In a lower middle-income country like Bangladesh, it is important to study symptom responses and impairments to determine the scope of rehabilitation and generate clinical trials and shreds of evidence. From recent studies in Bangladesh, 2,3 we understand the symptom responses, disease spectrum, and scope of rehabilitation but there are inconclusive answers on the rehabilitation interventions for LCS. From the fact sheets of WHO, we know rehabilitation interventions play an important for the clinical management of LCS.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive systematic scoping review for physiotherapy interventions for people living with long COVID

et al. 2023

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Background: A diverse spectrum of long COVID symptoms (LCS) have the scope of physical rehabilitation. Due to limited resources, very little is known about the physiotherapy and rehabilitation interventions for LCS and their clinical application. This study aims to explore the role of physiotherapy and rehabilitation interventions in the management of musculoskeletal, neurological, cognitive, cardiorespiratory, mental health, and functional impairments of LCS. Methods: The study was a systematic scoping review of the literature published between April 2020 and July 2022. Results: 87 articles were extracted followed by a standard process of The Preferred Reporting Items for Systematic reviews and meta-analysis (PRISMA) extension for Scoping reviews (PRISMA-ScR). The included studies had a 3223 LCS population. All types of primary and secondary articles were retrieved except for qualitative studies. The evidence was evaluated by an appraisal scoring tool followed by the guidelines of the “Enhancing the Quality and Transparency of health Research (EQUATOR) network”. The included papers had a mean appraisal score of 0.7807 on a 0 to 1 scale (SD 0.08), the minimum score was for study protocols (0.5870), and the maximum score was for Cohort studies (.8977). Sixty seven (67) evidence-based interventions were documented from 17 clinical categories. Conclusion: LCS can be treated by physiotherapy, exercise, and physical rehabilitation for musculoskeletal, neurological, cognitive, cardio-respiratory, mental health, and functional impairments at home or in clinical setups such as primary care settings by in-person care or telerehabilitation.

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Predictors of and Factors Associated with Novel Post COVID Symptoms in the Musculoskeletal, Functional, and Cognitive Domains for Vaccinated Delta-Variant Survivors: A Descriptive Survey of a Nationwide Prospective Inception Cohort in Bangladesh

Cited by 6 publications

References 0 publications

Clinical presentation of post-COVID pain and its impact on quality of life in long COVID patients: a cross-sectional household survey of SARS-CoV-2 cases in Bangladesh

Clinical presentation of post-COVID pain and its impact on quality of life in long COVID patients: a cross-sectional household survey of SARS-CoV-2 cases in Bangladesh

Profile of long COVID symptoms needing rehabilitation: a cross-sectional household survey of 12,925 SARS-CoV-2 cases between July and December 2021 in Bangladesh

A comprehensive systematic scoping review for physiotherapy interventions for people living with long COVID

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