Predictors of Acute Esophagitis in Lung Cancer Patients Treated With Concurrent Three-Dimensional Conformal Radiotherapy and Chemotherapy

Oral Glutamine Supplementation Reduces Radiotherapy-induced Esophagitis in Lung Cancer Patients

“…These results can be interpereted as follows: the risk of esophagitis is independent of the application of concomitant chemotherapy in GLNsupplemented group and concurrent chemotherapy does not increase the risk of esophagitis in this group. Rodriguez et al (2009) reported that patients with lung cancer treated by chemoradiotherapy with the application of prophylactic GLN showed lowest risk of developing esophagitis compared to other studies. This report supports our results.…”

“…Most of these studies reached different conclusions and there was no data about the relationship between dosimetric parameters and acute esophagitis (Rodriguez et al, 2009;Etiz et al, 2013). There was a clear relationship between dose-volume parameters and esophagitis however there were no absolute parameters associated with esophagitis.…”

“…This result is supported by Singh et al (Singh et al 2003) studies. It was also reported that concurrent chemotherapy was likely to increase the risk of esophagitis (Rodriguez et al, 2009). In our study, of the 23 patients who received concomitant chemotherapy 17 patients (73.9%) developed esophagitis at one time during treatment, but this result was not statistically significant.…”

Dosimetric and Clinical Predictors of Acute Esophagitis in Lung Cancer Patients in Turkey Treated with Radiotherapy

“…In addition, not only severe AE, but also intermediate and mild AE could be the reason of the late adverse effects according to Dorr et al this feature (superficial barrier function against mechanical and/or chemical stresses) also is valid for the intestines, oral mucosa, and urinary bladder (Dorr et al, 2001). Treatment of mild mucositis would prevent possible late adverse effects (Rodriguez et al, 2009). For this reason, such cases should be followed-up on for late adverse effects even if they are asymptomatic in terms of AE.…”

Acute Radiation Esophagitis Caused by High-Dose Involved Field Radiotherapy with Concurrent Cisplatin and Vinorelbine for Stage III Non-small Cell Lung Cancer

“…In order to reduce such toxicities, involved field radiotherapy (IFRT) without an elective nodal irradiation (ENI) has been developed (8)(9), and it has been demonstrated to be capable of dose escalation without increasing toxicities (10)(11)(12)(13)(14)(15). Predictive analyses of radiation pneumonitis and esophagitis by using a dose-volume histogram (DVH) have been investigated in many studies (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26); however, predictive values derived from a standard dose of 60 Gy with an ENI might not be applicable to high-dose IFRT for stage III NSCLC (7). We previously reported that 72 Gy in 36 fractions is the optimal dose that could be attained with maintenance of the normal tissue constraints (14).…”