Dosimetric and Clinical Predictors of Acute Esophagitis in Lung Cancer Patients in Turkey Treated with Radiotherapy

Etiz, Durmuş; Bayman, Evrim; Akçay, Melek; Sahin, Betul; Bal, Cengiz

doi:10.7314/apjcp.2013.14.7.4223

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…Most of these studies reached different conclusions and there was no data about the relationship between dosimetric parameters and acute esophagitis (Rodriguez et al, 2009;Etiz et al, 2013). There was a clear relationship between dose-volume parameters and esophagitis however there were no absolute parameters associated with esophagitis.…”

Section: Discussionmentioning

confidence: 99%

“…It is commonly assumed that the longer the length and volume of the esophagus segment included in the radiotheraphy field, the higher the probability of esophageal toxicity (Etiz et al, 2013), despite the fact that in the literature, different opinions have been expressed on this topic (Singh et al, 2003). It is not yet clear which parameters have a role in determining the development of esophagitis.…”

Section: Discussionmentioning

confidence: 99%

“…There are other studies investigating the relation between esophagitis and dosimetric parameters, such as the mean esophageal dose, maximum esophageal point dose (Jim et al, 2009;Etiz et al, 2013). In these studies, both of these parameters have been associated with the development of esophagitis.…”

Section: Discussionmentioning

confidence: 99%

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Oral Glutamine Supplementation Reduces Radiotherapy-induced Esophagitis in Lung Cancer Patients

Kanyılmaz¹,

Muge²,

A³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The purpose of this study was to assess the the efficacy of oral glutamine (GLN) in prevention of acute radiation-induced esophagitis in patients with lung cancer and determine the predictive role of clinical and dosimetric parameters. Materials and Methods: Thirty-two patients diagnosed with lung cancer were studied prospectively. Sixteen patients (50%) received prophylactic powdered GLN orally in doses of 10g/8h. Patients were treated 2 Gy per fraction daily, 5 days a week. We evaluated the grading of esophagitis daily at the end of each fraction of each treatment day until a cumulative dose of 50 Gy was reached. The primary end point was radiation-induced esophagitis. Results: All patients tolerated GLN well. Toxicity grade, weight loss, serum cytokine levels and esophageal transit times exhibited statistically significant improvement in the GLN receiving group. GLN suppressed the inflammation related to the disease and treatment and reduced toxicity with statistical significance. Conclusions: This study suggests a benefical role of oral GLN use in prevention and/or delay of radiation-induced esophagitis, in terms of esophageal transit time and serum immunological parameters, as well as weight loss.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Oral Glutamine Supplementation Reduces Radiotherapy-induced Esophagitis in Lung Cancer Patients

Kanyılmaz¹,

Muge²,

A³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Predictors for severe acute esophagitis in lung cancer patients treated with chemoradiotherapy: a systematic review

Gong

Jiang

et al. 2016

Current Medical Research and Opinion

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Clinical, dosimetric, and position factors for radiation-induced acute esophagitis in intensity-modulated (chemo)radiotherapy for locally advanced non-small-cell lung cancer

Huang

Yang

et al. 2018

OTT

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PurposeThe purpose of this study was to estimate the relation between acute esophagitis (AE) and clinical, dosimetric, and position factors in patients with locally advanced non-small-cell lung cancer (NSCLC) receiving intensity-modulated (chemo)radiotherapy.Materials and methodsA retrospective cohort analysis was performed to identify factors associated with Common Toxicity Criteria for Adverse Events grade 2 or worse AE (AE2+). A multivariable model was established including patient- and treatment-related variables and esophageal dose–volume histogram parameters. The esophagus was divided according to physiological anatomy, and logistic regression was used to analyze the position parameter for its correlation with AE2+.ResultsThe incidence of AE2+ was 27.5%. All models included gender, concurrent chemo-radiotherapy (CCRT), position parameter, and one of the dosimetric variables. The model with mean dose showed the best goodness of fit. Gender (OR=2.47, P=0.014), CCRT (OR=3.67, P=0.015), mean dose (OR=1.33, P<0.001), and maximum radiation position (OR=1.65, P=0.016) were significantly related to AE2+.ConclusionGender, concurrent chemotherapy, maximum radiation position, and mean dose were independent risk factors for AE2+. The upper part of the esophagus showed a higher sensitivity to radiation toxicity.

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Dosimetric and Clinical Predictors of Acute Esophagitis in Lung Cancer Patients in Turkey Treated with Radiotherapy

Cited by 3 publications

References 22 publications

Oral Glutamine Supplementation Reduces Radiotherapy-induced Esophagitis in Lung Cancer Patients

Oral Glutamine Supplementation Reduces Radiotherapy-induced Esophagitis in Lung Cancer Patients

Predictors for severe acute esophagitis in lung cancer patients treated with chemoradiotherapy: a systematic review

Clinical, dosimetric, and position factors for radiation-induced acute esophagitis in intensity-modulated (chemo)radiotherapy for locally advanced non-small-cell lung cancer

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