Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran

Bahardoust, Mansour; Heiat, Mohammad; Khodabandeh, Mehrdad; Karbasi, Ashraf; Bagheri‐Hosseinabadi, Zahra; Ataee, Mohammad Hossein; Seidalian, Narjes; Babazadeh, Amirhossein; Agah, Shahram; Abyazi, Mohammad Ali

doi:10.1038/s41598-021-82721-3

Cited by 24 publications

(26 citation statements)

References 22 publications

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“…Thus, identifying early biomarkers of disease severity on admission could expedite the early intensified therapy to reduce mortality. However, there are few reports of the prognostic capacity of early biomarkers of the disease, and the information in published studies are limited to age, sex (Jin et al, 2021a), neutrophil-to-lymphocyte ratio (NLR) , immunological cell defects (Du et al, 2020;Jin et al, 2021a), systemic inflammation response index; liver, heart, and kidney injuries, coagulation defects, and aggregate index of systemic inflammation in predicting mortality in COVID-19 patients (Bhargava et al, 2020;Fois et al, 2020;Bahardoust et al, 2021;Gallo Marin et al, 2021;Hariyanto et al, 2021). However, inflammatory responses and indicators to the microorganism-induced infection are not specific for COVID-19, leading to an uncertain diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis

Zhang

et al. 2022

Front. Cell. Infect. Microbiol.

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In the early stage of coronavirus disease 2019 (COVID-19), most cases are identified as mild or moderate illnesses. Approximately 20% of hospitalised patients become severe or critical at the middle or late stage of the disease. The predictors and risk factors for prognosis in those with mild or moderate disease remain to be determined. Of 694 patients with COVID-19, 231 patients with mild or moderate disease, who were hospitalised at 10 hospitals in Wenzhou and nearby counties in China, were enrolled in this retrospective study from 17 January to 20 March 2020. The outcomes of these patients included progression from mild/moderate illness to severe or critical conditions. Among the 231 patients, 49 (21.2%) had a poor prognosis in the hospital. Multivariate logistic regression analysis showed that higher inflammation/coagulopathy/immunology responsive index (ICIRI=[c-reactive protein × fibrinogen × D-dimer]/CD8 T cell count) on admission (OR=345.151, 95% CI=23.014−5176.318) was associated with increased odds ratios for poor prognosis. The area under the receiver operating characteristic curve for ICIRI predicting severe and critical condition progression was 0.65 (95% CI=0.519−0.782) and 0.80 (95% CI=0.647−0.954), with cut-off values of 870.83 and 535.44, respectively. Conversely, age, sex, comorbidity, neutrophil/lymphocyte ratio, CD8 T cell count, and c-reactive protein, fibrinogen, and D-dimer levels alone at admission were not good predictors of poor prognosis in patients with mild or moderate COVID-19. At admission, a novel index, ICIRI, tends to be the most promising predictor of COVID-19 progression from mild or moderate illness to severe or critical conditions.

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Section: Introductionmentioning

confidence: 99%

Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis

Zhang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…The prospective study design was another strength of our study compared to other studies. COVID-19 mortality rates have also been reported based on underlying diseases and socioeconomic [ 6 , 22 – 24 ]. According to our research so far, the study in Iran has not evaluated the outcomes of COVID-19 in orthopedic surgeries.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of early complications, outcome, and mortality in Coronavirus Disease 2019 (COVID-19) infection in patients who underwent orthopedic surgery

Mohammadpour

Yazdi

Bagherifard

et al. 2022

BMC Musculoskelet Disord

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Background A higher mortality and morbidity rate has been reported in COVID-19 patients undergoing surgery. To reduce the morbidity and mortality rate in COVID-19 patients undergoing orthopedic procedures, we aimed to increase the threshold for surgical planning. Methods In a prospective cohort study, COVID-19 patients who underwent elective or emergent orthopedic surgery in three orthopedic surgery centers from February 2020 to September 2020 were included. In this period, 6751 patients were scheduled for orthopedic surgery. To increase surgical threshold planning, all patients with grade 5 of the American Society of Anesthesiologists (ASA) classification and patients with COVID-19 related moderate to severe pulmonary involvement were identified as high-risk patients and were excluded. Results 35 deaths occurred during the study. The frequency of deaths was significantly higher in patients with COVID-19, 6 (9.4%) than patients without COVID-19, 29 (0. 43%). The average hospitalization stay was 12.8 ± 12.1 days. The odds ratio (OR) for death was significantly higher in patients with COVID-19 than patients without COVID-19. [OR: 8.13, Confidence interval 95% (CI95%) (5.02–11.25), P: 0.001]. Four (6.3%) COVID-19-associated complications were recorded in this series that all were respiratory failure requiring unexpected postoperative ventilation. Twenty surgical complications (31.3%) were recorded. The odds ratio for ICU admission was significantly higher in patients with COVID-19 than patients without COVID-19. [OR: 5.46, CI 95% (2.68–8.68), P: 0.001]. Conclusions An increased threshold for orthopedic surgery is suggested for COVID-19 patients with a mortality rate of 9.3%, which is less than the mortality rate in other studies. Level of evidence III.

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“…Sex of the COVID-19 infected patients have been previous reported to affect the disease progression and outcome of COVID-19 infection. Males are reported to be at higher risk of infection than females [ 44 ]. This can be further observed in many studies where the number of COVID-19 infected males are as much as twice the number of COVID-19 infected female [ 18 , 39 , 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Association of underlying comorbidities and progression of COVID-19 infection amongst 2586 patients hospitalised in the National Capital Region of India: a retrospective cohort study

et al. 2022

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This study is conducted to observe the association of diabetes (DM), hypertension (HTN) and chronic kidney disease (CKD) on the prognosis and mortality of COVID-19 infection in hospital admitted patients with above mentioned comorbidities. This is a single centre, observational, retrospective study carried out at Sir Ganga Ram Hospital, Delhi, India. The burden of comorbidities on the prognosis and clinical outcome of COVID-19 patients admitted patients from April 8, 2020, to October 4, 2020. Chi-square and relative risk test were used to observe the association of comorbidities and disease prognosis. A total of 2586 patients were included in the study consisting of 69.6% of male patients. All the comorbidities were significantly associated with ICU admission and mortality. The relative risk showed that CKD is most prone to severity as well as mortality of the COVID-19 infection followed by HTN and DM. Further with the increase in number of underlying comorbidities, the risk of ICU admission and mortality also increases. Relative risk of the severity of COVID-19 infection in younger patients with underlying comorbidities are relatively at higher risk of severity of disease as well as to mortality compared to the elderly patients with similar underlying condition. Similarly, it is found that females are relatively at higher risk of mortality as compared to the males having same comorbid conditions except for the hypertensive patients. Diabetes, hypertension and CKD, all are associated with progression of COVID-19 disease to severity and higher mortality risk. The number of underlying comorbid condition is directly proportional to the progression of disease severity and mortality. Supplementary Information The online version contains supplementary material available at 10.1007/s11010-022-04485-2.

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Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran

Cited by 24 publications

References 22 publications

Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis

Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis

Evaluation of early complications, outcome, and mortality in Coronavirus Disease 2019 (COVID-19) infection in patients who underwent orthopedic surgery

Association of underlying comorbidities and progression of COVID-19 infection amongst 2586 patients hospitalised in the National Capital Region of India: a retrospective cohort study

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