Predictors and clinical implications of atrial fibrillation in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation

Barbash, Israel M.; Minha, Sa’ar; Ben‐Dor, Itsik; Dvir, Danny; Torguson, Rebecca; Aly, Muhammad; Bond, Elizabeth; Satler, Lowell F.; Pichard, Augusto D.; Waksman, Ron

doi:10.1002/ccd.25708

Cited by 44 publications

(21 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Valvular heart disease is an independent predictor for the incidence of atrial fibrillation [4]. Atrial fibrillation negatively impacts on the clinical outcome of patients with severe heart valve disease, valve surgery and transcatheter aortic valve implantation [9,10,11,12]. However, the impact of atrial fibrillation on the clinical outcomes of patients with MR undergoing MitraClip implantation has not been determined, yet.…”

Section: Discussionmentioning

confidence: 99%

Atrial Fibrillation Predicts Long-Term Outcome after Transcatheter Edge-to-Edge Mitral Valve Repair by MitraClip Implantation

et al. 2018

View full text Add to dashboard Cite

Background: Atrial fibrillation is common in patients with mitral regurgitation (MR) and has a negative impact on the clinical outcome of patients with valvular heart disease. We aimed to evaluate the impact of pre-procedural atrial fibrillation on the long-term clinical outcomes of patients with MR undergoing transcatheter mitral valve repair by MitraClip implantation. Methods: We analysed 355 consecutive patients with and without atrial fibrillation with symptomatic, severe MR and inoperability or high surgical risk undergoing MitraClip implantation in a three-year follow-up. Results: In patients with pre-procedural atrial fibrillation undergoing MitraClip implantation, we found advanced age, higher baseline NT-pro-BNP levels, increased left atrial diameter, and higher rate of severe tricuspid regurgitation, compared to patients with sinus rhythm. In the three-year follow-up after MitraClip implantation, mortality and major adverse cardiovascular and cerebral events (MACCE) occur significantly more often in patients with atrial fibrillation, compared to patients without atrial fibrillation. Multivariate regression analysis confirmed atrial fibrillation (hazard ratio 2.39, 95%-confidence interval 1.06–5.41, p = 0.036) as an independent predictor for three-year-mortality after MitraClip implantation. Conclusions: Atrial fibrillation is an independent predictor for long-term mortality after MitraClip implantation. We demonstrate the association of atrial fibrillation with mortality and MACCE in the long-term follow-up of patients undergoing MitraClip implantation.

show abstract

Section: Discussionmentioning

confidence: 99%

Atrial Fibrillation Predicts Long-Term Outcome after Transcatheter Edge-to-Edge Mitral Valve Repair by MitraClip Implantation

et al. 2018

View full text Add to dashboard Cite

show abstract

“…W przybliżeniu u 30% pacjentów z AF występuje jakiegoś rodzaju wada zastawkowa, często wykrywana tylko za pomocą echokardiografii [201,[253][254][255]. Migotanie przedsionków pogarsza rokowanie u pacjentów z ciężkimi wadami zastawkowymi [256], w tym u poddawanych operacji lub interwencjom przezcewnikowym z powodu wady zastawki aortalnej lub mitralnej [257][258][259][260][261][262]. Wady zastawkowe mogą się wiązać ze zwiększonym ryzykiem zakrzepowo-zatorowym, które prawdopodobnie sumuje się z ryzykiem udaru mózgu u pacjentów z AF [263].…”

Section: Wady Zastawkoweunclassified

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof

Benussi

Kotecha³

et al. 2016

Kardiol Pol

2,386

4,206

View full text Add to dashboard Cite

“…201,[253][254][255] AF worsens prognosis in patients with severe valvular heart disease, 256 including those undergoing surgery or transcatheter interventions for aortic or mitral valve disease. [257][258][259][260][261][262] Valvular heart disease can be associated with an increased thromboembolic risk, which probably also adds to the stroke risk in AF patients. 263 Similar to heart failure, valvular disease and AF interact and sustain each other through volume and pressure overload, tachycardiomyopathy, and neurohumoral factors.…”

Section: Valvular Heart Disease 784mentioning

confidence: 99%

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Benussi²,

et al. 2016

View full text Add to dashboard Cite

Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document.When citing, please reference the published version. Take down policyWhile the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

show abstract

Predictors and clinical implications of atrial fibrillation in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation

Abstract: Baseline and postprocedure AF are common in AS patients undergoing TAVI. However, only postprocedure AF is associated with a prolonged and more complicated hospital course. AF is associated with poor long-term, but not short-term, mortality.

Cited by 44 publications

References 29 publications

Atrial Fibrillation Predicts Long-Term Outcome after Transcatheter Edge-to-Edge Mitral Valve Repair by MitraClip Implantation

Atrial Fibrillation Predicts Long-Term Outcome after Transcatheter Edge-to-Edge Mitral Valve Repair by MitraClip Implantation

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Contact Info

Product

Resources

About