2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof, Paulus; Benussi, Stefano; Kotecha, Dipak; Ahlsson, Anders; Atar, Dan; Casadei, Barbara; Castellà, Manuel; Diener, Hans‐Christoph; Heidbüchel, Hein; Hendriks, Jeroen; Hindricks, Gerhard; Manolis, Antonis S.; Oldgren, Jonas; Popescu, Bogdan A.; Schotten, Ulrich; Putte, Bart Van de; Vardas, Panagiotis

doi:10.5603/kp.2016.0172

Cited by 2,316 publications

(4,588 citation statements)

References 810 publications

(1,104 reference statements)

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“…Previous clinical trials have demonstrated that poor TTR is associated with adverse events including thromboembolism, bleeding, and/or mortality . To date, well‐controlled VKAs has been used TTR more than 70% as reflect in recommendations of recent clinical practice guidelines …”

Section: Discussionmentioning

confidence: 99%

“…To date, only oral anticoagulant drugs (OACs) are proven to prevent thromboembolism in those patients . According to standard clinical practice guidelines recommend OACs should be prescribed in AF patients with non‐sex CHA 2 DS 2 ‐VASc of 1 or more (score of ≥ 1 in a male or ≥2 in a female) …”

Section: Introductionmentioning

confidence: 99%

“…Until now, standard clinical practice guidelines recommend the use of HAS‐BLED score to predict bleeding risk in those patients . Labile INR in those score is defined as poor TTR (eg, TTR less than 60%) .…”

Section: Introductionmentioning

confidence: 99%

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Use of simplified HAS‐BLED score in patients with atrial fibrillation receiving warfarin

Methavigul

2019

Journal of Arrhythmia

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Background Oral anticoagulant drugs are proven to prevent thromboembolism in patients with atrial fibrillation (AF). To date, HAS‐BLED score is used to assess bleeding risk. This study was conducted to compare simplified HAS‐BLED (sHAS‐BLED) with conventional HAS‐BLED (cHAS‐BLED) scores. Methods This retrospective study recruited patients with AF receiving warfarin among July 2013 to December 2018 in Central Chest Institute of Thailand. The cHAS‐BLED score used the time in therapeutic range less than 70% as labile INR, whereas sHAS‐BLED score used SAMe‐TT2R2 score of 3 or more as a substitute for labile INR. A paired Student's t test was used to compare sHAS‐BLED and cHAS‐BLED. The Pearson's correlation was used to assess the correlation of sHAS‐BLED to cHAS‐BLED scores. The Bland‐Altman plot was used to confirm the agreement of individual sHAS‐BLED to cHAS‐BLED score. Results A total of 126 AF patients were enrolled. The average age, SAMe‐TT2R2 score, and cHAS‐BLED score were 70.52 ± 10.37 years, 3.53 ± 1.03, and 2.03 ± 0.95, respectively. The sHAS‐BLED score was not statistically significantly different compared with cHAS‐BLED score (P = .08). The sHAS‐BLED and cHAS‐BLED scores had a very strong correlation with a correlation coefficient of .86 (P < .01). The Bland‐Altman plot was performed to confirm the agreement of individual sHAS‐BLED to cHAS‐BLED scores. Conclusions The sHAS‐BLED was not statistically significantly different compared with cHAS‐BLED and can be used in clinical practice. However, larger clinical trial will be needed to prove whether sHAS‐BLED can predict bleeding risk in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Use of simplified HAS‐BLED score in patients with atrial fibrillation receiving warfarin

Methavigul

2019

Journal of Arrhythmia

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“…At present, the majority of clinical guidelines recommend the use of CHA 2 DS 2 -VASc score to aid decision on anticoagulation therapy (20)(21)(22)(23)(24). This tool was refined from the original 2006 Birmingham "National Institute for Health and Care Excellence" stroke risk schema with a specific focus on optimal identification of low-risk individuals and subsequently validated in several large AF cohorts (18,25).…”

Section: Stroke Risk Assessmentmentioning

confidence: 99%

“…Furthermore, many risk factors for bleeding contribute as well to stroke risk in AF. This highlights the complex relationship between thrombogenesis and bleeding, and represent the challenges faced by physicians when weighing up the risk and benefits of anticoagulation therapy (20).…”

Section: Bleeding Risk Assessmentmentioning

confidence: 99%

Stroke and Bleeding Risk Assessments in Patients With Atrial Fibrillation: Concepts and Controversies

et al. 2020

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Left Atrial Appendage Occlusion During Cardiac Operations for Prevention of Thromboembolic Events

Ferraris

2018

JAMA

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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Cited by 2,316 publications

References 810 publications

Use of simplified HAS‐BLED score in patients with atrial fibrillation receiving warfarin

Use of simplified HAS‐BLED score in patients with atrial fibrillation receiving warfarin

Stroke and Bleeding Risk Assessments in Patients With Atrial Fibrillation: Concepts and Controversies

Left Atrial Appendage Occlusion During Cardiac Operations for Prevention of Thromboembolic Events

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