Predictive values of acute coronary syndrome discharge diagnoses differed in the Danish National Patient Registry

Joensen, Albert Marni; Jensen, Majken K.; Overvad, Kim; Dethlefsen, Claus; Schmidt, Erik Berg; Rasmussen, Lars Hvilsted; Tjønneland, Anne; Johnsen, Søren Paaske

doi:10.1016/j.jclinepi.2008.03.005

Cited by 163 publications

(151 citation statements)

References 15 publications

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“…The MI diagnosis in the National Patient Register was based on current European Society of Cardiology criteria for MI, coded by the physician in charge of the discharge, and is known to have a high sensitivity (90%) and specificity (92%), which is unrelated to age. 21 We therefore identified nearly all patients with MI, and only a few patients were misclassified, reducing the risk of information bias. The overall necropsy rate declined from 44% in 1971 to 9% in 2001, 30 but medicolegal inquest is statutory when suicide is suspected.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Infarction and Risk of Suicide

et al. 2010

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Background-Myocardial infarction (MI) is associated with an increased risk of anxiety, depression, low quality of life, and all-cause mortality. Whether MI is associated with an increased risk of suicide is unknown. We examined the association between MI and suicide. Methods and Results-We conducted a population-based case-control study by retrieving data from 5 nationwide longitudinal registers in Denmark. As cases, we selected all persons aged 40 to 89 years who died by suicide from 1981 to 2006. As controls, we randomly selected up to 10 persons per case matched by sex, day of birth, and calendar time.We identified 19 857 persons who committed suicide and 190 058 controls. MI was associated with a marked increased risk of suicide. The risk of suicide was highest during the first month after discharge for MI for patients with no history of psychiatric illness (adjusted rate ratio, 3.25; 95% confidence interval, 1.61 to 6.56) and for patients with a history of psychiatric illness (adjusted rate ratio, 64.05; 95% confidence interval, 13.36 to 307.06) compared with those with no history of MI or psychiatric illness. However, the risk remained high for at least 5 years after MI. Conclusions-MI is followed by an increased risk of suicide for persons with and without psychiatric illness. Our results suggest the importance of screening patients with MI for depression and suicidal ideation. (Circulation.

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Section: Discussionmentioning

confidence: 99%

Myocardial Infarction and Risk of Suicide

et al. 2010

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“…31 Briefly, we identified all participants in the Diet, Cancer and Health cohort who were registered with an incident discharge diagnosis of ACS in the Danish National Patient Registry until January 1, 2004. Medical records were retrieved and reviewed to ensure that all patients fulfilled the criteria of ACS according to current recommendations for epidemiological studies from the American Heart Association and other major health organizations.…”

Section: Methodsmentioning

confidence: 99%

Marine n-3 Polyunsaturated Fatty Acids in Adipose Tissue and the Risk of Acute Coronary Syndrome

et al. 2011

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Background-Marine n-3 polyunsaturated fatty acids may reduce coronary mortality. Previous data in relation to nonfatal coronary disease, however, have been inconsistent, which may be explained by the use of heterogeneous methods to assess the intake of marine n-3 polyunsaturated fatty acids. We investigated the hypothesis that the content of total and individual marine n-3 polyunsaturated fatty acids in adipose tissue is negatively associated with the incidence of acute coronary syndrome (ACS), including both fatal and nonfatal coronary disease. Methods and Results-In the Diet, Cancer and Health, a Danish cohort study, 57 053 subjects were enrolled and had an adipose tissue biopsy taken at inclusion. During a mean follow-up period of 7.6 years, we identified and verified all cases (nϭ1012) with an incident acute coronary syndrome diagnosis, and a random sample of the cohort (nϭ1630) had their fatty acid composition in adipose tissue determined by gas chromatography. We found negative dose-response associations between the content of total marine n-3 polyunsaturated fatty acids and individual n-3 polyunsaturated fatty acids in adipose tissue and the risk of acute coronary syndrome. Comparing men in the highest and lowest quintiles gave a hazard ratio of 0.65 (95% confidence interval, 0.45 to 0.95) for total n-3 polyunsaturated fatty acids and 0.51 (95% confidence interval, 0.36 to 0.73) for docosahexaenoic acid. Nonfatal cases constituted Ͼ86% of cases, and the association was driven primarily by a reduction in the risk of nonfatal acute coronary syndrome. No consistent associations were found among women. Conclusion-Intake of marine n-3 polyunsaturated fatty acids may protect against acute coronary syndrome in men.

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“…Similarly, some studies also reported a wide range of positive predictive values of cardiac arrhythmia or cardiac arrest in different databases. [33][34][35] …”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Cardiovascular outcomes associated with use of clarithromycin: population based study

Wong

Root

Douglas

et al. 2016

BMJ

166

193

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Study queStionWhat is the association between clarithromycin use and cardiovascular outcomes? MethodSIn this population based study the authors compared cardiovascular outcomes in adults aged 18 or more receiving oral clarithromycin or amoxicillin during 2005-09 in Hong Kong. Based on age within five years, sex, and calendar year at use, each clarithromycin user was matched to one or two amoxicillin users. The cohort analysis included patients who received clarithromycin (n=108 988) or amoxicillin (n=217 793). The self controlled case series and case crossover analysis included those who received Helicobacter pylori eradication treatment containing clarithromycin. The primary outcome was myocardial infarction. Secondary outcomes were all cause, cardiac, or non-cardiac mortality, arrhythmia, and stroke. Study anSwer and liMitationSThe propensity score adjusted rate ratio of myocardial infarction 14 days after the start of antibiotic treatment was 3.66 (95% confidence interval 2.82 to 4.76) comparing clarithromycin use (132 events, rate 44.4 per 1000 person years) with amoxicillin use (149 events, 19.2 per 1000 person years), but no long term increased risk was observed. Similarly, rate ratios of secondary outcomes increased significantly only with current use of clarithromycin versus amoxicillin, except for stroke. In the self controlled case analysis, there was an association between current use of H pylori eradication treatment containing clarithromycin and cardiovascular events. The risk returned to baseline after treatment had ended. The case crossover analysis also showed an increased risk of cardiovascular events during current use of H pylori eradication treatment containing clarithromycin. The adjusted absolute risk difference for current use of clarithromycin versus amoxicillin was 1.90 excess myocardial infarction events (95% confidence interval 1.30 to 2.68) per 1000 patients.what thiS Study addS Current use of clarithromycin was associated with an increased risk of myocardial infarction, arrhythmia, and cardiac mortality short term but no association with long term cardiovascular risks among the Hong Kong population.

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Predictive values of acute coronary syndrome discharge diagnoses differed in the Danish National Patient Registry

Cited by 163 publications

References 15 publications

Myocardial Infarction and Risk of Suicide

Myocardial Infarction and Risk of Suicide

Marine n-3 Polyunsaturated Fatty Acids in Adipose Tissue and the Risk of Acute Coronary Syndrome

Cardiovascular outcomes associated with use of clarithromycin: population based study

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