Predictive Value of Spectral-Domain Optical Coherence Tomography Features in Assessment of Visual Prognosis in Eyes With Neovascular Age-Related Macular Degeneration Treated With Ranibizumab

Optical Coherence Tomographic Features and Visual Prognosis after Treatment for Idiopathic Choroidal Neovascularization

“…Our study did not reveal a clear association between visual recovery and central macular thickness, in agreement with previous investigations by El-Emam et al [10] and Hayashi et al [21], and in contrast to other studies [22,23,24]. Other morphological parameters such as subfoveal choroidal thickness and the diameter and thickness of the choroidal neovascular membrane were not significantly correlated with final visual acuity or visual improvement, neither in our study nor in previous ones [10,17]. …”

“…Previous studies on patients undergoing intravitreal medical therapy for neovascular age-related macular degeneration or diabetic macular edema or those undergoing surgery for macular holes showed that all eyes with an absent ELM did not have a preserved ellipsoid zone, while in contrast, eyes with a preserved ELM could show a damaged or absent ellipsoid zone [17,18,19]. This suggests that either the ELM recovered faster as compared with the ellipsoid zone or that the ELM was more resistant to the disease.…”

Factors Associated with Recurrence of Age-Related Macular Degeneration after Anti-Vascular Endothelial Growth Factor Treatment

“…Several studies have recently reported the morphologic features as the predictive factors for visual outcomes with ranibizumab treatment for neovascular AMD. 39,40 Further studies should be performed to confirm the relationship between multifarious factors and recurrence in the aim of developing the optimal strategy of maintenance treatment with good outcomes, fewer injections, and clinic visits.…”

Prognostic Value of Hyperreflective Foci in Neovascular Age-Related Macular Degeneration Treated With Bevacizumab

“…17 Presence of a single HF in either the outer or the inner retinal layers was considered as involvement of that layer. The amount of HF was classified as few (0-10), moderate (11)(12)(13)(14)(15)(16)(17)(18)(19)(20), or many (.20) as previously described. 15 In addition, the presence or absence of the HF adjacent to IRF or subretinal fluid (defined as HF at the edge of a cystoid space or within it) was recorded as well.…”

“…The pigment epithelial detachment was defined as any inward deviation of the normal counter of the RPE with an optically empty area external and was measured from the top of the RPE to the top of the Bruch membrane. 16 Areas of pigment epithelial detachment with hyperreflective material (hyperreflective pigment epithelial detachment) within them were marked and measured using the built-in caliper scale and overlays function (provided by the software of the Spectralis OCT device), which enables to display and measure the area marked. In addition, the following parameters were recorded from the automatic calculation of the Spectralis OCT after segmentation error corrections: CRT, maximum central retinal thickness (MCRT), and central retinal volume in the central 6 mm.…”