Predictive value of <scp>NGAL</scp> for use of renal replacement therapy in patients with severe sepsis

Hjortrup, Peter Buhl; Haase, Nicolai; Treschow, Frederik; Møller, Morten Hylander; Perner, Anders

doi:10.1111/aas.12427

Cited by 40 publications

(33 citation statements)

References 36 publications

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“…Therefore, psoriasis seems to associate with increased levels of inflammatory markers in saliva and it is remarkable that in our study patients with psoriasis had significantly lower levels of salivary NGAL as compared to patients with periodontitis and orally healthy controls, respectively. NGAL is an inflammation‐related protein, and increased levels of NGAL in the circulation and urine have been intensively investigated as a marker of acute kidney injury (Hjortrup, Haase, Treschow, Møller, & Perner, ). Also, in periodontitis a positive correlation has been found between urinary levels of NGAL and the severity of periodontitis (Nakajima et al, ).…”

Section: Discussionmentioning

confidence: 99%

Salivary microbiota and inflammation‐related proteins in patients with psoriasis

et al. 2020

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Objective The purpose of the present study was to characterize the composition of the salivary microbiota and quantify salivary levels of inflammation‐related proteins (neutrophil gelatinase‐associated lipocalin [NGAL] and transferrin) in patients with psoriasis and compare data to those obtained in patients with periodontitis and orally healthy controls, respectively. Materials and methods Stimulated saliva samples from patients with psoriasis (n = 27), patients with periodontitis (n = 58), and orally healthy controls (n = 52) were characterized by means of next‐generation sequencing of the 16S rRNA gene. Salivary levels of NGAL and transferrin were quantified using immunoassays. Results Linear discriminant effect size analysis showed that 52 (22 psoriasis‐associated and 30 periodontitis‐associated) and 21 (8 psoriasis‐associated and 13 orally healthy control‐associated) bacterial taxa differentiated the salivary microbiota in patients with psoriasis from that of patients with periodontitis and orally healthy controls, respectively. Significantly lower mean salivary levels of NGAL (psoriasis: 996 [std. error 320], periodontitis: 2,072 [295], orally healthy controls: 2,551 [345] ng/ml, p < .0001) and transferrin (psoriasis: 4.37 [0.92], periodontitis: 7.25 [0.88], orally healthy controls: 10.02 [0.94] ng/ml, p < .0001) were identified in patients with psoriasis. Conclusions Psoriasis associates with characteristics of the salivary microbiota and salivary levels of inflammation‐related proteins, which are different from characteristics in patients with periodontitis and orally healthy controls, respectively.

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Section: Discussionmentioning

confidence: 99%

Salivary microbiota and inflammation‐related proteins in patients with psoriasis

et al. 2020

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“…Sex is classified as female vs male, SOFA scores are shown with increasing ORs per point increase, and sCr is shown with increasing ORs per 10 mmol/L. urine NGAL in patients with severe sepsis which found low predictive power for the use of RRT, AKI, and 90-day mortality [37,38]. Finally, wbNGAL values were found to be quite elevated in this entire cohort of patients.…”

Section: Discussionmentioning

confidence: 79%

Whole-blood neutrophil gelatinase-associated lipocalin to predict adverse events in acute kidney injury: A prospective observational cohort study

Rewa

Wald

Adhikari

et al. 2015

Journal of Critical Care

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“…CRP is a 115 kDa molecule formed by five monomers that are bound together by relatively fragile calcium bridges. [16][17][18] Most CRP circulates in the blood as a 22-25 kDa monomer. Theoretically, monomeric CRP is removed by CRRT as its molecular weight is below the cutoff of classical membranes (ie, 35 kDa).…”

Section: Biomarkers Of Sepsis: a Seven-league Boots Advancementioning

confidence: 99%

“…16 Further research is needed to obtain biomarkers with sufficient diagnostic and prognostic specificity to discriminate between an ongoing septic process and an associated AKI. 17 Research to interfere in this fascinating universe of interacting pathways is on the brink of a breakthrough.…”

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confidence: 99%

Biomarkers in critical illness: have we made progress?

Honoré¹,

Jacobs²,

Hendrickx³

et al. 2016

IJNRD

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Biomarkers have emerged as exemplary key players in translational medicine. Many have been assessed for timely recognition, early treatment, and adequate follow-up for a variety of pathologies. Biomarker sensitivity has improved considerably over the last years but specificity remains poor, in particular when two "marker-sensitive" conditions overlap in one patient. Biomarker research holds an enormous potential for diagnostic and prognostic purposes in postoperative and critically ill patients who present varying degrees of inflammation, infection, and concomitant (sub)acute organ dysfunction or failure. Despite a remarkable progress in development and testing, biomarkers are not yet ready for routine use at the bedside.

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Predictive value of NGAL for use of renal replacement therapy in patients with severe sepsis

Abstract: In ICU patients with severe sepsis, plasma and urine NGAL had low predictive power for use of RRT, AKI and 90-day mortality. These results were supported by sensitivity and exploratory analyses.

Cited by 40 publications

References 36 publications

Salivary microbiota and inflammation‐related proteins in patients with psoriasis

Salivary microbiota and inflammation‐related proteins in patients with psoriasis

Whole-blood neutrophil gelatinase-associated lipocalin to predict adverse events in acute kidney injury: A prospective observational cohort study

Biomarkers in critical illness: have we made progress?

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