Predictive value of pre-therapy 18F-FDG PET/CT for the outcome of 18F-FDG PET-guided radiotherapy in patients with head and neck cancer

Abstract

FDG PET/CT uptake parameters are predictors of patients' outcome and can potentially identify patients with higher risk of treatment failure that could benefit from more aggressive approaches. Application of PVC is recommended for accurate measurement of PET parameters.

Hypoxic glucose metabolism in glioblastoma as a potential prognostic factor

“…The two parameters were strongly correlated (Pearson's R=0.90; p<0.0001). Previous studies in head-and-neck cancer patients showed that both MTV and TLG were significant predictors [36][37][38][39][40], and some of them show the superiority of TLG [36,39]. Because TLG represents the total amount of FDG taken up in the tumor lesion (i.e., mathematically, TLG is the integral of FDG SUV within the tumor boundary), TLG might reflect both tumor cell number and malignancy per cell.…”

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“…Substantial efforts have been focused on studying the identification of novel biologic parameters to further stratify risk groups with the goal of individualized treatment strategies for patients. PET-CT as an imaging modality has emerged as the standard of care in recent years for HNC patients aiding in staging, radiotherapy planning, and follow-up of treatment responses [8,11]. The ability of PET-CT to systematically measure tumor burden may directly predict locoregional control and survival as compared with previous identified clinical and pathological prognostic factors including age, anatomic subsite, and co-morbidity scores.…”

“…18 F-fluorodeoxydeglucose positron emission tomography with computed tomography (PET-CT) plays a major role in the management of HNC patients owing largely to its ability to systematically measure tumour burden [7][8][9][10]. As a result it has become the standard of care in many centers for staging, evaluation of nodal and distant metastasis as well as key roles in radiation planning [7,10,11].…”

Radiation Treatment of Lymph Node Recurrence from Prostate Cancer: Is 11C-Choline PET/CT Predictive of Survival Outcomes?

“…In different oncologic diseases, 18 F-FDG PET-derived parameters have demonstrated predictive significance. In particular, SUV measurement has been described as a useful parameter describing tumor uptake (25)(26)(27)(28)(29). Notably, MTV can provide information complementary to that obtained by more commonly used SUV measurement, in particular a decrease in MTV according to 18 F-FDG uptake correlates with higher long-term OS and may be used in the prediction of progression-free survival (30)(31)(32).…”