Predictive Value of Mean Platelet Volume for Pulmonary Embolism Recurrence

Araz, Ömer; Albez, Fadime Sultan; Uçar, Elif Yılmazel; Kerget, Buğra; Yılmaz, Nafiye; Akgün, Metin

doi:10.1007/s00408-017-0020-7

Cited by 12 publications

(16 citation statements)

References 28 publications

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“…Our most interesting finding is the demonstration of prognostic significance of higher values of PDW on admission in internal medicine wards. Higher PDW levels have recently been reported to be associated with increased morbidity and mortality in numerous clinical investigations that focused on patients with critical illness [11,13], and with specific acute and chronic disorders [10,[14][15][16][17][18][19][20][21][22][23]. We observed that PDW values above the cut-off of 16.7% at admission, as well as above the normal range, were associated with an increased risk of mechanical ventilation and death during the current hospitalization, and shortened survival following discharge.…”

Section: Discussionmentioning

confidence: 53%

“…Increased PDW values have been reported in patients with diabetes mellitus [5], cancer [6,7], and cardiocerebrovascular and respiratory disorders [8][9][10][11][12]. Moreover, higher PDW levels have recently been reported to be associated with increased morbidity and mortality among patients with critical illness [11,13], coronary artery disease [14][15][16][17], cancer [18][19][20][21], pulmonary embolism [10,22], and chronic obstructive pulmonary disease [23]. Most previous studies on the clinical significance of PDW involved patients with specific disorders.…”

Section: Introductionmentioning

confidence: 99%

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Platelet distribution width: a novel prognostic marker in an internal medicine ward

Tzur

Barchel

Izhakian

et al. 2019

Journal of Community Hospital Internal Medicine Perspectives

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Background: Platelet distribution width (PDW) has demonstrated clinical significance in populations with specific disorders; its prognostic significance in internal medicine wards has not been investigated. Methods: Demographic, clinical and laboratory data were collected prospectively for 1036 internal medicine inpatients. The primary outcome was 90-day mortality, secondary outcomes were: treatment with mechanical ventilation, prolonged hospital stay, in-hospital death, and all-cause mortality following discharge. Data were assessed according to PDW values on admission ≤16.7% (group A) and >16.7% (group B). Results: Compared to group A patients (n = 273), group B patients (n = 763) were more likely to be older, admitted for cardio-cerebrovascular disorder, to present with comorbidities, to be mechanically ventilated, to have prolonged hospital stay and to die during the current hospitalization. The respective 90-day and total (median follow-up of 5 months) mortality rates were significantly higher in group B (13.2% and 16.3%) than in group A (6.6% and 9.5%), P < 0.01. On multivariate analysis, higher PDW values on admission predicted 90-day mortality and shortened survival (relative risks 1.58 and 1.26; 95% confidence intervals 0.89 − 2.78 and 0.97-1.64, respectively). Conclusion: Higher PDW values on admission to internal medicine wards are associated with a more severe clinical profile and increased risk of 90-day mortality.

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Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Platelet distribution width: a novel prognostic marker in an internal medicine ward

Tzur

Barchel

Izhakian

et al. 2019

Journal of Community Hospital Internal Medicine Perspectives

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“…Platelet distribution width (PDW) has also been demonstrated as another sign of platelet activation which measures the variability in platelet size. Additionally, a significant association between increased MPV and both arterial and venous diseases such as myocardial infarction (MI) and PTE, has been shown in previous studies [13,14]. There is a need for an easy and quick assessment method for screening PTE in cancer patients.…”

Section: Introductionmentioning

confidence: 94%

Does the Platelet Index Have a Guiding Role in the Association of Cancer and Pulmonary Thromboembolism?

Öcal¹,

Öcal²

2020

Multidiscip Cancer Investig

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Introduction: The diagnostic value of the D-dimer test varies with variable platelet numbers and functions in patients suffering from cancer and concomitant pulmonary thromboembolism (PTE). This requires easy and reliable evaluation tests. In this study, we aimed to investigate the hypothesis that platelet functions may be more guiding in the prediction and diagnosis of PTE rather than the number of platelets in cancer pa- tients. Methods: The clinical, laboratory and radiological findings of all patients diagnosed with PTE were retrieved, retrospectively. Comparisons were performed between “can- cer-free” and “cancer” patients. The patients were also evaluated according to their active and remission status. Results: The data of 232 patients with PTE were reviewed. 172 patients were cancer- free and 60 were diagnosed with cancer. The mean values of D-dimer, mean platelet volume (MPV) and platelet distribution width (PDW) were found to be significantly higher in patients with cancer (P=0.015, P=0.026, and P=0.023; respectively). On the other hand, mean platelet counts were significantly higher in patients without cancer (P=0.05). It was also observed that the mean values of D-dimer, Troponin-I, MPV, and PDW were found to be significantly higher in patients with active cancer (P=0.05, P=0.044, P=0.05, and P=0.042; respectively). However, the mean platelet counts were significantly higher in patients with cancer who were in remission (P=0.05). Conclusions: The morphological characteristics of the platelets are more determinant than the number of platelets in cancer patients with PTE. Platelet indexes such as MPV and PDW may be useful in the prediction, diagnosis, and follow-up of PTE in patients with cancer.

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“…A meta-analysis on thrombosis and MPV published in 2017 reported that the onset of PE had no significant effect on the standardized mean difference (MD) of MPV between patients with PE and controls [ 12 ]. However, large sample studies on MPV and PE were subsequently conducted [ 13 , 14 ], and they showed a significant increase in MPV among patients with new PE onset and recurrent PE. A meta-analysis published in 2020 demonstrated an increased MPV associated with PE but not assessed the use of MPV as an indicator for the risk prediction and risk stratification of PE [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Association between mean platelet volume and pulmonary embolism: a systematic review and meta-analysis

Lin

et al. 2021

Aging

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Platelet activation plays an important role in the progression of pulmonary embolism (PE). Mean platelet volume (MPV) can serve as a marker of platelet activity in patients with PE. Many studies have reported different results regarding the relationship. Therefore, we aimed to perform a systematic review and meta-analysis to evaluate the relationship between MPV and PE. Two reviewers independently searched relevant articles in databases from inception to April 21, 2021 and identified all studies on MPV and PE as the outcomes of interest. Further, we selected studies meeting the criteria and extracted the data. Of the 2505 publications identified, we included 18 studies after screening. Results showed MPV was significantly higher in patients with PE (0.83 fL, 95% CI: 0.38-1.28, P<0.001) than in controls. The mean difference in MPV between those who died and survivors of PE was 1.23 fL (95% CI: 0.96-1.51, P<0.001). Hence, an increased MPV is associated with PE. MPV could be a useful tool to predict the occurrence and death risk of PE together with other risk factors.

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Predictive Value of Mean Platelet Volume for Pulmonary Embolism Recurrence

Abstract: MPV seems to be an indicator of recurrence in pulmonary embolism and may have utility in the prediction of recurrence. Elevated MPV can also be used to predict mortality in pulmonary embolism.

Cited by 12 publications

References 28 publications

Platelet distribution width: a novel prognostic marker in an internal medicine ward

Platelet distribution width: a novel prognostic marker in an internal medicine ward

Does the Platelet Index Have a Guiding Role in the Association of Cancer and Pulmonary Thromboembolism?

Association between mean platelet volume and pulmonary embolism: a systematic review and meta-analysis

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