Association between mean platelet volume and pulmonary embolism: a systematic review and meta-analysis

Lin, Wenyi; Wu, Yu; Lu, Xuan; Hu, Yu

doi:10.18632/aging.203205

Cited by 10 publications

(8 citation statements)

References 41 publications

(55 reference statements)

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“…Multiple studies have shown that increased mean platelet volume (MPV) may reflect thrombotic risk ( 56 , 57 ), and that MPV can serve as a marker of platelet activity in patients with pulmonary embolism ( 58 ). In a very recent large-scale clinical assessment study, cardiovascular events were found to increase early after COVID-19 mainly from pulmonary embolism, atrial arrhythmias, and venous thrombosis ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

Platelets’ morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients

Yasseen

Elkhodiry²,

El-Messiery³

et al. 2022

Front. Immunol.

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Roles of platelets during infections surpass the classical thrombus function and are now known to modulate innate immune cells. Leukocyte-platelet aggregations and activation-induced secretome are among factors recently gaining interest but little is known about their interplay with severity and mortality during the course of SARS-Cov-2 infection. The aim of the present work is to follow platelets’ bioenergetics, redox balance, and calcium homeostasis as regulators of leukocyte-platelet interactions in a cohort of COVID-19 patients with variable clinical severity and mortality outcomes. We investigated COVID-19 infection-related changes in platelet counts, activation, morphology (by flow cytometry and electron microscopy), bioenergetics (by Seahorse analyzer), mitochondria function (by high resolution respirometry), intracellular calcium (by flow cytometry), reactive oxygen species (ROS, by flow cytometry), and leukocyte-platelet aggregates (by flow cytometry) in non-intensive care unit (ICU) hospitalized COVID-19 patients (Non-ICU, n=15), ICU-survivors of severe COVID-19 (ICU-S, n=35), non-survivors of severe COVID-19 (ICU-NS, n=60) relative to control subjects (n=31). Additionally, molecular studies were carried out to follow gene and protein expressions of mitochondrial electron transport chain complexes (ETC) in representative samples of isolated platelets from the studied groups. Our results revealed that COVID-19 infection leads to global metabolic depression especially in severe patients despite the lack of significant impacts on levels of mitochondrial ETC genes and proteins. We also report that severe patients’ platelets exhibit hyperpolarized mitochondria and significantly lowered intracellular calcium, concomitantly with increased aggregations with neutrophil. These changes were associated with increased populations of giant platelets and morphological transformations usually correlated with platelets activation and inflammatory signatures, but with impaired exocytosis. Our data suggest that hyperactive platelets with impaired exocytosis may be integral parts in the pathophysiology dictating severity and mortality in COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Platelets’ morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients

Yasseen

Elkhodiry²,

El-Messiery³

et al. 2022

Front. Immunol.

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“…This meta-analysis did not provide information on mortality and bleeding events. [2] In a meta-analysis of 18 studies including 2674 patients and 1192 control groups, Lin et al [3] found an increase in MPV consistent with the diagnosis of PE (p<0.001) and also found a relationship between the increase in MPV and the mortality of pulmonary thromboembolism patients (p<0.001). This meta-analysis highlighted the heterogeneity between groups and the causes of mortality were not studied.…”

Section: Discussionmentioning

confidence: 99%

Pulmoner Tromboembolide Platelet İndeksleri ile Radyolojik Tutulum Arasındaki İlişki

Akgün¹

2023

IGH

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Objective: Pulmonary thromboembolism (PTE) is a disease characterized by occlusion of the pulmonary artery and its branches by thrombus material as a result of stasis, hypercoagulability, and/or endothelial damage. Recent studies have focused on platelet (PLT) parameters, mortality of the disease, and its use as a diagnostic parameter. In particular, a significant relationship was found between high mean PLT volume (MPV) values and mortality and disease risk in the meta-analyses. The aim of our study is to examine the relationship between PLT parameters and the severity of radiological involvement. Material and Methods:The files of patients who were followed up with the diagnosis of pulmonary thromboembolism between 2012 and 2021 were reviewed retrospectively. The patients were radiologically divided into 3 groups: (1) those with major branch involvement, (2) those with segmental branch involvement without major branch involvement, and (3) those with only subsegmental branch involvement. In addition, patients were examined in two separate groups according to whether there was more than 50% of involvement in the main branch radiologically and whether the right ventricle/left ventricle ratio was above 0.9 or not, radiologically. PLT, neutrophil, lymphocyte, platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio, MPV, plateletcrit (PCT), platelet distribution width (PDW), and PLT large cell ratio data in complete blood count measurements taken from patients at the time of diagnosis were also recorded.Results: There was a significant correlation between rising in PLR and occlusion in the major branch more than 50% (p=0.041). PLT, PDW, PCT, and neutrophil values differed radiologically according to the involvement of major, segment, and subsegment; however, subgroup analyses did not provide the linear difference that we expected in our study.

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“…However in some studies no significant association was found between MPV and PE diagnosis. 28 , 29 In their systematic review, Lin et al 3 stated that although MPV is predictive in the diagnosis and severity assessment of PE, there may be research results resulting from different effects of MPV in patients with different risk levels for PE. In another study, Moharamzadeh et al 30 found no increase or difference in MPV, PDW, and P-LCR among platelet indices in patients with PE.…”

Section: Discussionmentioning

confidence: 99%

“… 2 However, these examinations are relatively costly, less feasible, and have limited use in primary care hospitals. 3 D-dimer, one of the laboratory parameters is commonly requested in the diagnostic phase but its poor specificity has limited its diagnostic efficiency. Therefore hemogram parameters have been investigated in the diagnosis of PE recently because they are cheap and easily accessible.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hemogram Parameters in the Diagnosis of Pulmonary Embolism: Immature Granulocytes and Other New Tips

Karakurt,

Guven,

Aynaci

et al. 2024

Clin Appl Thromb Hemost

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Pulmonary embolism (PE) is an important cause of sudden death and is difficult to diagnose. Therefore unnecessary radiological investigations are often resorted to. Although some inflammatory parameters in the hemogram have been found to play a role in the diagnosis of PE, many parameters have not been adequately investigated. We aimed to evaluate potential inflammatory parameters in hemogram in the diagnosis of PE and to determine the parameters with the highest diagnostic value. This single-center, retrospective study was performed by evaluating 114 cases with suspected PE admitted to the emergency department between January 2017 and June 2022. Among 114 cases, 62 cases with a definitive diagnosis of PE by pulmonary computed tomography angiography served as the PE group and 52 cases without PE served as the control group. Admission hemogram parameters of both groups were recorded. Potential chronic diseases and acute conditions affecting hemogram were excluded from the study. In the multivariate model; immature granulocyte (IG), neutrophil/lymphocyte ratio (NLR), monocyte % and platelet large cell ratio (P-LCR) were found to be significantly and independently effective in differentiating cases with and without PE ( P˂.05). Our findings suggest that high IG, high NLR, high monocyte %, and low P-LCR values have diagnostic value in cases with suspected PE. However the usability of IGs in the diagnosis of PE is a new finding. Hemogram is cheap, easily accessible, and potential inflammatory biomarkers in hemograms may increase physicians’ awareness in the diagnosis of PE.

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Association between mean platelet volume and pulmonary embolism: a systematic review and meta-analysis

Cited by 10 publications

References 41 publications

Platelets’ morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients

Platelets’ morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients

Pulmoner Tromboembolide Platelet İndeksleri ile Radyolojik Tutulum Arasındaki İlişki

Evaluation of Hemogram Parameters in the Diagnosis of Pulmonary Embolism: Immature Granulocytes and Other New Tips

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