Predictive value of maternal serum human chorionic gonadotropin levels in pregnancies achieved by in vitro fertilization with single cleavage and single blastocyst embryo transfers

Oron, Galia; Esh-Broder, Efrat; Son, Weon‐Young; Holzer, Hananel; Tulandi, Togas

doi:10.1016/j.fertnstert.2015.02.028

Cited by 27 publications

(23 citation statements)

References 35 publications

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“…The transfer of more than one embryo therefore affects the initial p‐hCG levels and may influence possible correlations between hCG levels and pregnancy or perinatal outcomes even in singleton pregnancies. Inclusion of different assisted reproductive techniques as well as the inclusion of p‐hCG measured on different days may also influence results. In early pregnancy, p‐hCG levels increase rapidly and standardization of the interval between fertilization and hCG measurement may optimize the prediction of outcome, especially if cut‐off values are proposed.…”

Section: Introductionmentioning

confidence: 99%

“…After implantation, human chorionic gonadotropin (hCG) is the first trophoblast signal detected in maternal blood and is used to diagnose pregnancy (1). Early plasma hCG (p-hCG) levels are predictive of pregnancy outcome (2)(3)(4)(5)(6)(7)(8)(9)(10)(11) and are routinely measured in in vitro fertilization (IVF) clinics to plan early pregnancy followup. Very few studies are restricted to single embryo transfer (SET) (5,11), and no studies have focused on Day-2 SET.…”

Section: Introductionmentioning

confidence: 99%

“…Early plasma hCG (p-hCG) levels are predictive of pregnancy outcome (2)(3)(4)(5)(6)(7)(8)(9)(10)(11) and are routinely measured in in vitro fertilization (IVF) clinics to plan early pregnancy followup. Very few studies are restricted to single embryo transfer (SET) (5,11), and no studies have focused on Day-2 SET. Day-2 transfers account for 73% of fresh IVF ª 2017 Nordic Federation of Societies of Obstetrics and Gynecology, Acta Obstetricia et Gynecologica Scandinavica 96 (2017) 960-967 transfers in Denmark in women <40 years of age, and according to national guidelines, SET should be the standard.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Predictive value of plasma human chorionic gonadotropin measured 14 days after Day‐2 single embryo transfer

Løssl

Oldenburg

Toftager

et al. 2017

Acta Obstet Gynecol Scand

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Predictive value of plasma human chorionic gonadotropin measured 14 days after Day‐2 single embryo transfer

Løssl

Oldenburg

Toftager

et al. 2017

Acta Obstet Gynecol Scand

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“…Kathiresan et al (2011) showed that initial β-hCG level has a prognostic role in pregnancy and it is associated with the embryo transfer day. 22 Oron et al (2015) revealed that initial hCG levels were higher in blastocyst transfer than cleavage embryo transfers in single embryo transfers and reported that hCG level has a predictive role in pregnancy achievement. 23 In this study, too, it is seen that as embryo transfer day increased, β-hCG levels increased statistically and significantly.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Kalem¹,

Kalem²,

Gürgan³

2017

TJRMS

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-hCG (beta-human chorionic gonadotrophin) is a pregnancy-associated molecule produced by implanted blastocysts and trophoblastic cells. β-hCG as one of the earliest embryonal signals may be a major regulator in the paracrine embryo-endometrial communication.1,2 β-hCG measurement in serum is a method used routinely for pregnancy test after the IVF (invitro fertilization) procedure.3 Serial measurements of β-hCG is a marker which is also used for distinguishing pregnancies running their course from ectopic pregnancy or spontaneous pregnancy losses in early pregnancy. [4][5][6] In increasing number of recent studies, it has become a current issue that β-hCG levels in early A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The purpose of this study is to investigate the parameters of female, male and cycles that could affect post-ART (assisted reproductive techniques)-pregnancy initial beta hCG value. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In this retrospective study, data of 3056 individuals who had become pregnant with IVF/ICSI at a private IVF center and between 2006 and 2016 and whose pregnancies continued for over 12 weeks were evaluated. Initial beta-hCG values of these pregnancies were compared with parameters of mothers, fathers and cycles. R Re es su ul lt ts s: : It was seen in this study that there is a negative correlation between the initial beta-hCG values of pregnancies achieved by assisted reproductive techniques and mothers BMI values and a positive correlation between those beta-hCG values and the embryo transfer day. C Co on nc cl lu us si io on n: : The data obtained in the study need to be supported with larger series in the future. It is also thought that these data may contribute to the literature which tries to achieve a β -hCG cut-off value in the determination of pregnancy outcome. Ya zış ma Ad re si/Cor res pon den ce:

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“…Many prior studies have explored the relationship between serum β-hCG levels and pregnancy outcomes. In fresh embryo transfer cycles, the thresholds of serum β-hCG levels to predict clinical pregnancy and live births were 111-213 IU/L and 160-222.8 IU/L respectively 10-12 days after transfer [2][3][4][5][6][7]. For frozen embryo transfer, the cut-off value was 137-399 IU/L for clinical pregnancy and 212-411 IU/L for live births 11-12 days after embryo transfer [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Possibility of Live Birth in Patients with Low Serum β-hCG 14 Days After Blastocyst Transfer

Liu²

2020

Preprint

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Background: Although prior work has attempted to predict pregnancy outcomes by assaying serum β-hCG levels after blastocyst transfer, no study has focused on pregnancy outcomes in those with initially low serum β-hCG levels. This study sought to investigate pregnancy outcomes of patients with low serum β-hCG levels 14 days after blastocyst transfer.Methods: A retrospective study was conducted at the Third Affiliated Hospital of Guangzhou Medical University to study patients whose serum β-hCG levels were at 5-299 mIU/ml 14 days after frozen blastocyst transfer. Rates of live birth, early miscarriage, biochemical pregnancy loss and ectopic pregnancy were analyzed according to the female patients’ age by Chi-squared analysis. Receiver operating characteristic (ROC) curves were plotted to explore the threshold of predicting clinical pregnancy and live births. Results: 312 patients had serum β-hCG levels <300 mIU/ml at 14 days after frozen blastocyst transfer, among which, 18.6% were live births, 47.4% were early miscarriages, 22.8% were biochemical pregnancies and 9.6% were ectopic pregnancies. Live birth rates were higher in the <38 years of age group as compared those > 38 years (19.0% vs.16.6%; P=0.045). ROC curve analysis showed that a predicted value of β-hCG for clinical pregnancy was 58.8 mIU/ml with an area under the ROC curve (AUC) of 0.752, a sensitivity of 95.0% and specificity of 53.5%. The threshold for live births was 108.6 mIU/ml with an AUC of 0.649, a sensitivity of 93.1% and a specificity of 37.0%. For the β-hCG fold increase over 48 hours, the cut-off for clinical pregnancy was 1.4 with an AUC of 0.899, a sensitivity of 90.3% and a specificity of 77.8%. The threshold for live birth was 1.9 with an AUC of 0.808, a sensitivity of 88.5% and specificity of 64.5%.Conclusions: Initially low serum β-hCG levels 14 days after frozen blastocyst transfer indicated minimal chances of live birth. For patients having an initial β-hCG >58.8 mIU/ml, luteal phase support should continue. Another serum β-hCG test and ultrasound should be performed one week later. When an initial serum β-hCG is < 58.8 mIU/ml, luteal phase support should be discontinued and serum β-hCG measured with ultrasound one week later.

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Predictive value of maternal serum human chorionic gonadotropin levels in pregnancies achieved by in vitro fertilization with single cleavage and single blastocyst embryo transfers

Cited by 27 publications

References 35 publications

Predictive value of plasma human chorionic gonadotropin measured 14 days after Day‐2 single embryo transfer

Predictive value of plasma human chorionic gonadotropin measured 14 days after Day‐2 single embryo transfer

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Possibility of Live Birth in Patients with Low Serum β-hCG 14 Days After Blastocyst Transfer

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