Predictive Value of Malnutrition Markers for Mortality in Peritoneal Dialysis Patients

Leinig, Cyntia Erthal; Ribeiro, Silvia Carreira; Riella, Miguel C.; Olandoski, Márcia; Martins, Cristina; Pecoits‐Filho, Roberto

doi:10.1053/j.jrn.2010.06.026

Cited by 68 publications

(65 citation statements)

References 32 publications

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“…However, the serum albumin level is also a marker of systemic inflammation [47]. Previous studies showed that PD patients with low serum albumin levels had higher serum C-reactive protein levels and higher mortality rates [49,50,51,52]. Our result further supports the notion that HSP plays an important role in the background inflammatory state of stable PD patients.…”

Section: Discussionsupporting

confidence: 87%

Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients

Poon¹,

Szeto²,

Kwan³

et al. 2014

Nephron Clin Pract

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Background: Heat shock proteins (HSPs) are expressed by cells in response to various environmental stresses. A single-nucleotide polymorphism A+1267G of the HSPA1B gene affects the expression of HSP70-2, with the A allele being protective against inflammatory conditions. We investigated the relation between the HSP A+1267G polymorphism and the clinical outcomes of Chinese peritoneal dialysis (PD) patients. Methods: We studied 347 new PD cases (181 males, age 56.6 ± 13.7 years). Genotyping was done by standard methods. Patients were followed for 40.5 ± 20.7 months for survival analysis. Results: For the entire cohort, there was no difference in the 5-year survival between genotype groups. However, there was a significant interaction between HSP polymorphism and diabetic status on the cardiovascular event-free survival. In patients without pre-existing diabetes, 5-year cardiovascular event-free survival of the GG/AG genotype group was significantly better than that of the AA genotype group (57.2 vs. 32.1%, p = 0.011). Conclusion: The G allele of the HSP70-2 A+1267G polymorphism confers survival advantages in non-diabetic PD patients. The role of HSP in the pathogenesis of cardiovascular disease in renal failure patients needs further investigation.

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Section: Discussionsupporting

confidence: 87%

Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients

Poon¹,

Szeto²,

Kwan³

et al. 2014

Nephron Clin Pract

View full text Add to dashboard Cite

show abstract

“…Consequently, it remains unclear if persons with higher comorbidity profiles were more likely to initiate dialysis earlier. Since poor nutritional status at dialysis initiation is a known predictor of mortality in patients with CKD 52–54 , we attempted to minimize this potential bias by using hazard ratios that were adjusted for several patient characteristics including nutritional indicators. However, the observational design of our analysis limits causal inference, and full adjustment for known and unknown confounders.…”

Section: Discussionmentioning

confidence: 99%

GFR at Initiation of Dialysis and Mortality in CKD: A Meta-analysis

Susantitaphong

Altamimi

Ashkar

et al. 2012

American Journal of Kidney Diseases

102

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“…In scientific journals, prevalence of malnutrition among these patients varies from 18 to 75% depending on screening methods [5,6]. Malnutrition should be prevented because it largely contributes to the high rates of morbidity and mortality recorded among these patients.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Nutritional Status of Hemodialysis Patients in a Sub-Saharan Country

Bl¹,

Vd²,

Vigan³

et al. 2017

J Kidney

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Objective: Identifying which of the three scores (MNA, SGA and ISRNM) would better assess the nutritional status of chronic hemodialysis patients in BeninPatients and Methods: We conducted a cross-sectional, descriptive and analytical study. It was carried out over a three-month period, from 1 st July to 31 st September 2015. The study participants included patients who have been on hemodialysis for at least the past 6 months, non-admitted in the past 4 weeks and having given their consent to participate in the study. All patients were subject to anthropometric parameters and checkups in order to apply the three nutritional scores: Mini Nutritional Assessment (MNA); Suggestive Global Assessment (SGA); International Society of Renal Nutrition and Metabolism (ISRNM criteria). Statistical analysis was performed through EpiData Ver 3.1.Outcomes: 149 patients were selected including 38.93% of women and 61.07% of men. Age ranged from 19 to 79 years with 48 ± 12.88 as mean age. The prevalence of overall malnutrition was respectively 42.75%; 36.24% and 14.09% based on MNA, SGA and ISRNM scores. There was poor protein intake in 85.19% of cases, body mass index (BMI) was below 23 kg/m ² in 68.46% of cases, hypoalbuminemia and pre-dialysis hypocreatininemia were recorded in respectively 29.53% and 52.38% of cases. Conclusion:SGA score seems to be a more objective score as it uses both history and clinical data. BMI and protein intake when considered distinctly, have a better predictive value of our patients nutritional status.

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Predictive Value of Malnutrition Markers for Mortality in Peritoneal Dialysis Patients

Cited by 68 publications

References 32 publications

Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients

Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients

GFR at Initiation of Dialysis and Mortality in CKD: A Meta-analysis

Assessing the Nutritional Status of Hemodialysis Patients in a Sub-Saharan Country

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