Predictive value of liver tissue flow in assessment of the viability of liver grafts after extended preservation in pigs

Kim, Y. I.; Kai, Tetsuji; Kawano, Katsunori; Goto, Shigeru; Kodama, Yuko; Yasunaga, Fumitaka; Takeyama, Masaharu; Akizuki, Shin’ichiro; Kamada, Nanao; Kobayashi, Michio

doi:10.1007/978-3-642-77423-2_114

Cited by 4 publications

(1 citation statement)

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“…The measurement of tissue perfusion, therefore, is a key point to understand both normal and pathologic physiology. Many techniques, such as laser-Doppler flowmetry, radioactive microsphere technique, have been used to measure tissue blood flow (7)(8)(9). Previous methods, however, have been inefficient to measure local tissue perfusion (10,11).…”

Section: Discussionmentioning

confidence: 99%

Nicardipine Augments Local Myocardial Perfusion after Coronary Artery Reperfusion in Dogs

Jang

Kim

2003

J Korean Med Sci

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INTRODUCTIONThe measurement of perfusion is very important to understand the physiology at the tissue level. And local myocardial perfusion (LMP) can identify hypoperfused myocardial tissue more precisely. In particular, during ischemia the myocardial layers of the left ventricle can be ischemic, while the epicardial blood flow is preserved. Many drugs have been used to improve the myocardial function in patients with coronary disease, and they may affect the LMP by various mechanisms (1-5). Nicardipine, a dihydropyridine calcium antagonist, is one of the most commonly used drugs to control the high blood pressure after coronary artery bypass graft. Nicardipine has relatively selective coronary vascular action (6). However, there has been no study of identifying the nicaridipine effects in myocardium by using LMP after the coronary reperfusion.Therefore, this study was undertaken to evaluate the nicadipine's effect in myocardial layers after the coronary reperfusion. The LMP and left anterior descending coronary blood flow (BF-LAD) before and after left anterior descending coronary artery (LAD) occlusion were evaluated according to the nicardipine administration. MATERIALS AND METHODSThis investigations were performed under a protocol approved by the Institutional Animal Investigation Committee, Keimyung University, Daegu, Korea. A total of 14 mongrel dogs, weighing 20-25 kg, were entered into the study. We divided the dogs into two groups, control group (n=7) and nicardipine group (n=7). The anesthesia was induced by 20 mg/kg thiopental sodium and 0.2 mg/kg vecuronium bromide followed by tracheal intubation after 2 min. Mechanical ventilation was done with 50% nitrous oxide in oxygen and 1-1.5 vol% isoflurane with a tidal volume of 15 mL/kg with a respiratory rate of 12/min.A left thoracotomy was performed on the 5th or 6th intercostal space and LAD was exposed for occlusion and release. A thermal diffusion microprobe (TDM) was implanted in the myocardium perfused by the exposed LAD. To prevent the TDM displacement during cardiac contraction, the TDM was sutured in place. The TDM was then connected to QFlow J Korean Med Sci 2003; 18: 23-6 ISSN 1011-8934 Copyright � The Korean Academy of Medical Sciences 23 Nicardipine Augments Local Myocardial Perfusion after Coronary Artery Reperfusion in DogsNicardipine is a potent coronary and systemic vasodilator without depression of ventricular function. We investigated the changes in local myocardial perfusion (LMP) according to the nicardipine administration after coronary reperfusion in a beating canine model. A Doppler probe was placed around the left anterior descending coronary artery (LAD) and thermal diffusion microprobe was implanted in the myocardium perfused by the exposed LAD. To define the nicardipine effects, we compared the two groups (control group, n=7 vs nicardipine group, n=7). In nicardipine group, 5 g/kg/min nicardipine was infused continuously. After the release of the LAD occlusion, LAD blood flow were increased compared to the baseline of both...

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