Predictive value of IL-35 and IL-17 in diagnosis of childhood asthma

Mansour, Amira I.; Almonaem, Eman Rateb Abd; Behairy, Ola Galal; Gouda, Tahany M.

doi:10.1080/00365513.2017.1328739

Cited by 15 publications

(6 citation statements)

References 34 publications

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“…Our results show that the sputum concentrations of IL-35 are lower in asthmatics than in healthy controls, which support the results of a previous experiment on IL-35 plasma concentration [26] and a study in children [27]. However, another study evaluated the plasma concentrations of IL-35 by ELISA and found that the IL-35 level in patients with allergic asthma was significantly higher than that in patients with non-allergic asthma [16].…”

Section: Discussionsupporting

confidence: 90%

Different expression levels of interleukin-35 in asthma phenotypes

Gao

Xin

et al. 2020

Respir Res

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Background: Interleukin (IL)-35 is a newly discovered inhibitory cytokine which is produced by regulatory B and T lymphocytes and belongs to the IL-12 family. It plays a suppressive role in human inflammatory diseases; however, its role in asthma phenotypes is unclear. Our study focuses on the sputum IL-35 level in patients and investigates different airway inflammation capacities of sputum IL-35 in patients with different asthma phenotypes. Objective: We aimed to determine the sputum IL-35 levels in asthmatic patients with clinical remission phenotypes and control subjects and to investigate possible correlations among lung function, age, sex, fractional exhaled nitric oxide (FeNO), and smoking history in these phenotypes. Methods: Sputum samples were collected from patients with clinical asthma remission (n = 89, 37 males, age 52.24 ± 13.32 years) and a healthy control group (n = 19, 9 males, age 44.58 ± 16.3 years). All subjects underwent sputum induction. Induced sputum was assessed for inflammatory cell count, and sputum levels of IL-35 and other cytokines were measured by ELISA and Cytometric Bead Array, respectively. Results: Sputum IL-35 (median (q1, q3)) levels showed no significant difference between asthma patients (4.89 ng/ mL (2.97, 22.75)) and healthy controls (6.01 ng/mL (4.09, 30.47)). However, the sputum IL-35 level was significantly reduced in patients with eosinophilic asthma (EA) (3.95 ng/mL (2.80, 11.00)) compared to patients with neutrophilic asthma (NA) (40.59 ng/mL (20.59, 65.06), p = 0.002), paucigranulocytic asthma (PA) (6.25 ng/mL (3.10, 24.60), p = 0.012), and mixed granulocytic asthma (MA) (22.54 ng/mL (2.58, 52.45), p = 0.026). IL-35 levels in sputum showed a positive correlation with sputum neutrophil cells and a negative correlation with FeNO, FEV1% predicted, and FVC predicted. Furthermore, sputum IL-35 had a significant positive association with Th1-related factors and a negative correlation with Th2-related factors. Conclusions: Sputum IL-35 is likely involved in different pathophysiological mechanisms of NA and EA and exerts different effects in asthma phenotypes.

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Section: Discussionsupporting

confidence: 90%

Different expression levels of interleukin-35 in asthma phenotypes

Gao

Xin

et al. 2020

Respir Res

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“…However, the effect of IL-35 on human asthma remains unclear. In contrast to Iranian studies, down-regulated IL-35 level was found in some literature that was inversely related to serum IL-4 or IL-17, and IgE levels in childhood asthma (35,36). These contrasting results might be due to the various factors involved in the studies, such as different populations or methodologies.…”

Section: Resultscontrasting

confidence: 58%

Cytokine Levels and Polymorphisms in Childhood Asthma Among the Iranian Population

et al. 2021

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Context: Chronic airway inflammation in asthma is affected by a complex network of interacting cytokines. The exact role of each cytokine in childhood asthma development has remained poorly understood. In this study, we aimed to review articles investigating cytokine levels and polymorphisms in childhood asthma among the Iranian population to assess susceptible cytokines related to childhood asthma. Evidence Acquisition: We performed a literature search in PubMed, Scopus, Science direct, and Embase databases to find articles that have evaluated the cytokine levels and gene polymorphisms in childhood asthma among the Iranian population until March 2, 2020. The terms used to search included “cytokine”, “interleukin”, “polymorphism”, “Asthma”, and “Iran” in the international databases. Only case-control studies with a healthy control group that investigated cytokine levels and polymorphism in childhood asthma among the Iranian population have been included. Results: Considering these criteria, we extracted 7 articles from international databases and included them in the current review. We investigated 4 cytokine levels and 4 cytokine polymorphism patterns in asthmatic and non-asthmatic subjects in Iran. Interleukin (IL)-23, IL-17, and IL-33 levels were statistically higher in asthmatic children, and also IL-33, IL-17 levels were associated with asthma severity. There were no significant differences between healthy and asthmatic subjects regarding IL-35 levels. Polymorphisms in cytokine IL-4, IL-10, tumor necrosis factor (TNF)-α, and IL-2 were susceptible to childhood asthma in the Iranian population. Conclusions: Increased IL-33 and IL-17 levels were related to disease severity in childhood asthma. Four cytokine polymorphisms (IL-4, IL-10, IL-2, and TNF-α) were associated with the risk of pediatric asthma in the Iranian population.

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“… 153 High levels of serum IL-17 have been also detected in children with asthma and, together with serum IgE and blood eosinophils, they could have a predictive value in diagnosing childhood asthma. 154 Furthermore, both serum IL-17 and IL-17 + T cells have been associated with asthma severity in children. 155 , 156 …”

Section: Biomarkers In Childhood Asthmamentioning

confidence: 99%

Asthma Endotyping and Biomarkers in Childhood Asthma

Licari

Brambilla

Marseglia

et al. 2018

Pediatric Allergy, Immunology, and Pulmonology

136

102

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Childhood asthma represents a heterogeneous challenging disease, in particular in its severe forms. The identification of different asthma phenotypes has stimulated research in underlying molecular mechanisms, such as the endotypes, and paved the way to the search for related specific biomarkers, which may guide diagnosis, management, and predict response to treatment. A limited number of biomarkers are currently available in clinical practice in the pediatric population, mostly reflecting type 2-high airway inflammation. The identification of biomarkers of childhood asthma is an active area of research that holds a potential great clinical utility and may represent a step forward toward tailored management and therapy: the so-called Precision Medicine. The aim of the present review is to provide an updated overview of asthma endotyping, mostly focusing on novel noninvasive biomarkers in childhood asthma.

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Predictive value of IL-35 and IL-17 in diagnosis of childhood asthma

Cited by 15 publications

References 34 publications

Different expression levels of interleukin-35 in asthma phenotypes

Different expression levels of interleukin-35 in asthma phenotypes

Cytokine Levels and Polymorphisms in Childhood Asthma Among the Iranian Population

Asthma Endotyping and Biomarkers in Childhood Asthma

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