Predictive Value of Hematologic Inflammatory Markers in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

Red-cell distribution width as a prognostic marker for aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis

“…On the other hand, Huang et al, Hong et al, and Ignacio et al only measured baseline RDW levels. 14 , 15 , 16 The cut-off value ranged from 13.4% to 16%, according to the respective studies' laboratory cut-off. Baseline characteristics (not shown in the table) differed significantly in the study by Chugh et al, Siegler et al, and Fontana et al, in which group with a high RDW tended to be older and with more severe aSAH.…”

“…Four studies with a total of 711 samples assessed the relationship between RDW value and functional outcome. 11 , 12 , 13 , 16 Ignacio et al and Siegler et al evaluated functional outcome at discharge, while Chugh et al and Fontana et al evaluated during a 3-month follow-up. Overall, higher RDW correlated with a worse functional outcome with an OR of 1.70 (95% CI 1.32–2.19; p < 0.0001).…”

“…Five studies with a total of 1170 samples assessed the relationship between RDW value and mortality. 11 , 12 , 14 , 15 , 16 Fontana et al, Huang et al, and Ignacio et al recorded hospital mortality, while Chugh et al and Hong et al recorded mortality over 90 days. Higher RDW increased the mortality rate with OR 2.16 (95% CI 1.25–3.72; p = 0.006).…”

“…Three studies with a total of 671 samples assessed the relationship between RDW and cerebral infarction. 12 , 13 , 16 They excluded other possible causes but did not elaborate further on the methods and time at which infarction occurred. High RDW translated to a higher risk of cerebral infarction with OR 2.74 (95% CI 1.71–4.40; p < 0.0001) ( Fig.…”

Neutrophil to lymphocyte ratio predicting poor outcome after aneurysmal subarachnoid hemorrhage: A retrospective study and updated meta-analysis

“…found that NLR was negatively correlated with mean cerebral blood flow (mCBF) in brain CT perfusion scan of aSAH patients, and positively correlated with mean transit time (MTT) and mean time to peak (mTTP), suggesting slow and insufficient cerebral blood flow ( 5 ). Many studies have reported that elevated NLR can predict DCI occurrence after aSAH ( 9 , 22 , 23 ), whereas some studies have denied the correlation between them ( 19 ), so we conducted a meta-analysis of relevant literature. As mentioned above, our results show that elevated NLR is significantly correlated with the DCI occurrence after aSAH.…”