Red-cell distribution width as a prognostic marker for aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis

Lukito, Patrick P.; Lie, Hendry; Angelica, Vanessa; Wijovi, Felix; Nathania, Regina; July, Julius

doi:10.1016/j.wnsx.2023.100202

Cited by 3 publications

(2 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2023r. Lukito et al performed meta-analysis in which they found that high RDW value was signi cantly correlated with poor functional outcome, mortality and DCI [51]. Importantly enough, our study ndings are consistent with analyses involving other possible biomarkers and RDW.…”

Section: Discussionsupporting

confidence: 89%

Prognostic Biomarkers for Delayed Cerebral Ischemia Post-Aneurysmal Subarachnoid Hemorrhage: Evaluating CSF 8-iso-Prostaglandin F2α and Erythrocyte Anisocytosis

Wiśniewski,

Zaczkowski,

Szmyd

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Delayed cerebral ischemia (DCI) is a serious, life-threatening, complication affecting patients who have survived the initial bleeding from a ruptured intracranial aneurysm. Due to the challenging diagnosis, potential DCI prognostic markers should be of value in clinical practice. According to recent reports isoprostanes and red blood cell distribution (RDW) showed to be promising in this respect. Methods We conducted a prospective study with a control group (n=8), recruiting aSAH patients (n=27), who underwent surgery within the first day of the initial bleeding. We collected data regarding clinical status and results of biochemical, and radiological examinations. We measured cerebrospinal fluid (CSF) concentration of 8-iso-prostaglandin F2α (F2-IsoP) and RDW on day 1, 3, and 5. Results Both CSF F2-IsoP level and RDW measured on day 1 were significant predictors of DCI. The receiver operating characteristics curve for DCI prediction based on the multivariate model yielded an area under the curve (AUC) of 0.924 (95%CI: 0.824-0.1, p<0.01). Conclusions In our study, the model based on the combination of RDW and the level of isoprostanes in CSF on the first day after the initial bleeding showed a prognostic value for DCI prediction. Further studies are required to validate this observation.

show abstract

Section: Discussionsupporting

confidence: 89%

Prognostic Biomarkers for Delayed Cerebral Ischemia Post-Aneurysmal Subarachnoid Hemorrhage: Evaluating CSF 8-iso-Prostaglandin F2α and Erythrocyte Anisocytosis

Wiśniewski,

Zaczkowski,

Szmyd

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…[21] One systematic review and meta-analysis exploring the association of RDW with prognosis in aneurysmal subarachnoid hemorrhage patients confirmed that higher RDW was associated with a worse functional outcome, a worse discharge and 3-month functional outcome, and a higher in-hospital and 90-day mortality. [22] In another study carried in 8175 community-dwelling adults 45 years or older and exploring the association between RDW and risk of death, the results showed that RDW was a widely available test and a strong predictor of mortality in the general population of adults 45 years or older. [23] In our study, the univariate analysis results showed that the levels of RDW on the preoperative day, the 1st, 3rd and 7th postoperative days were all associated with the prognosis of aSAH patients, further suggesting that RDW might be a highly advantageous prognostic indicator.…”

Section: Discussionmentioning

confidence: 99%

Associations of neutrophil to lymphocyte ratio and red cell distribution width on different days with the prognosis of aneurysmal subarachnoid hemorrhage patients

Min,

Zhao,

Wang

et al. 2023

Medicine

View full text Add to dashboard Cite

The associations of neutrophil to lymphocyte ratio (NLR) and red cell distribution width (RDW) with the prognosis of aneurysmal subarachnoid hemorrhage (aSAH) patients were confirmed in a few studies. But NLR and RDW levels in most of these studies were on admission. Here we carried 1 retrospective study including 150 patients with aSAH who underwent surgeries in the First Affiliated Hospital of Yangtze University from January 2020 to February 2023 to explore the associations on the preoperative day, the first (1st), third (3rd), and seventh (7th) postoperative days. The level of RDW on the 3rd postoperative day and level of NLR on the 7th postoperative day in patients with poor prognosis were significantly higher than patients with good prognosis. The results of multivariate logistic analysis also confirmed the associations of RDW on the 3rd postoperative day (OR = 16.785, 95% CI: 4.077–69.107, P < .001) and NLR on the 7th postoperative day (OR = 8.399, 95% CI: 2.167–32.544, P = .002) with prognosis of aSAH patients. The results of receiver operating characteristic curve showed that cutoff values of RDW and NLR for predicting the prognosis in aSAH patients were 13.05% and 6.97, respectively. Higher RDW on the 3rd postoperative day and NLR on the 7th postoperative day were possibly associated with poor prognosis of aSAH patients. We should pay attention to the RDW and NLR levels during different hospitalization periods, especially in the short postoperative period. Moreover, the cutoff values for predicting prognosis need to be validated in larger-sample studies.

show abstract

Evaluation of CSF 8-iso-prostaglandin F2α and erythrocyte anisocytosis as prognostic biomarkers for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Wiśniewski,

Zaczkowski,

Szmyd

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Delayed cerebral ischemia (DCI) is a serious, life-threatening, complication affecting patients who have survived the initial bleeding from a ruptured intracranial aneurysm. Due to the challenging diagnosis, potential DCI prognostic markers should be of value in clinical practice. According to recent reports isoprostanes and red blood cell distribution (RDW) showed to be promising in this respect. We conducted a prospective study of 27 aSAH patients and control group (n = 8). All patients from the study group were treated within the first day of the initial bleeding. We collected data regarding clinical status and results of biochemical, and radiological examinations. We measured cerebrospinal fluid (CSF) concentration of 8-iso-prostaglandin F2α (F2-IsoP) and RDW on days 1, 3, and 5. Both CSF F2-IsoP level and RDW-SD measured on day 1 were significant predictors of DCI. The receiver operating characteristics curve for DCI prediction based on the multivariate model yielded an area under the curve of 0.924 (95% CI 0.824–1.000, p < 0.001). In our study, the model based on the combination of RDW and the level of isoprostanes in CSF on the first day after the initial bleeding showed a prognostic value for DCI prediction. Further studies are required to validate this observation.

show abstract

Red-cell distribution width as a prognostic marker for aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis

Cited by 3 publications

References 65 publications

Prognostic Biomarkers for Delayed Cerebral Ischemia Post-Aneurysmal Subarachnoid Hemorrhage: Evaluating CSF 8-iso-Prostaglandin F2α and Erythrocyte Anisocytosis

Prognostic Biomarkers for Delayed Cerebral Ischemia Post-Aneurysmal Subarachnoid Hemorrhage: Evaluating CSF 8-iso-Prostaglandin F2α and Erythrocyte Anisocytosis

Associations of neutrophil to lymphocyte ratio and red cell distribution width on different days with the prognosis of aneurysmal subarachnoid hemorrhage patients

Evaluation of CSF 8-iso-prostaglandin F2α and erythrocyte anisocytosis as prognostic biomarkers for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Contact Info

Product

Resources

About