Predictive Value of Fibrinogen-to-Albumin Ratio for Post-Contrast Acute Kidney Injury in Patients Undergoing Elective Percutaneous Coronary Intervention

Wang, Can; Li, Gaoye; Liang, Xiaomei; Qin, Chunyu; Luo, Qiuhu; Song, Rui; Chen, Wu-Xian

doi:10.12659/msm.924498

Cited by 9 publications

(11 citation statements)

References 14 publications

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“…It was shown that FAR was an independent predictor of severe CAD (OR = 1.060; 95% CI: 1.005–1.118, p < 0.05) and that FAR was an independent prognostic factor for MACE at 30 days, 6 months, and 1 year after DES implantation (HR = 1.095; 95% CI: 1.011–1.186, p = 0.025; HR = 1.076; 95% CI: 1.009–1.147, p = 0.026; HR = 1.080; 95% CI: 1.022–1.141, p = 0.006) [ 61 ]. From a clinical point of view, the results of the study by Wang et al are also important, showing that FAR was independently associated with the occurrence of post-contrast acute kidney injury (PC-AKI) and could significantly improve PC-AKI prediction over the Mehran risk score in patients undergoing elective PCI [ 62 ].…”

Section: Fibrinogen and Cardiovascular Riskmentioning

confidence: 99%

Fibrinogen and Atherosclerotic Cardiovascular Diseases—Review of the Literature and Clinical Studies

Surma

Banach

2021

IJMS

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Atherosclerotic cardiovascular diseases (ASCVD), including coronary artery disease, cerebrovascular disease, and peripheral arterial disease, represent a significant cause of premature death worldwide. Biomarkers, the evaluation of which would allow the detection of ASCVD at the earliest stage of development, are intensively sought. Moreover, from a clinical point of view, a valuable biomarker should also enable the assessment of the patient’s prognosis. It has been known for many years that the concentration of fibrinogen in plasma increases, inter alia, in patients with ASCVD. On the one hand, an increased plasma fibrinogen concentration may be the cause of the development of atherosclerotic lesions (increased risk of atherothrombosis); on the other hand, it may be a biomarker of ASCVD, as it is an acute phase protein. In addition, a number of genetic polymorphisms and post-translational modifications of fibrinogen were demonstrated that may contribute to the risk of ASCVD. This review summarizes the current data on the importance of fibrinogen as a biomarker of ASCVD, and also presents the relationship between molecular modifications of this protein in the context of ASCVD.

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Section: Fibrinogen and Cardiovascular Riskmentioning

confidence: 99%

Fibrinogen and Atherosclerotic Cardiovascular Diseases—Review of the Literature and Clinical Studies

Surma

Banach

2021

IJMS

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“…Histopathological studies have con rmed signi cant tubular vacuolar transformation, interstitial edema, and tubular degeneration in PC-AKI model induced by iopromide (Chen et al, 2020). The hypertonic environment produced by iopromide can also cause changes in renal hemodynamics, increase the hydrostatic pressure, and reduce the glomerular ltration rate (GFR) [5].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Salvianolic acid B alleviates the injury of HK-2 cells induced by iopromide through inhibiting the activation of NLRP3 inflammasome

Pei

Dong

Gao

et al. 2022

Preprint

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Purpose In this study, we conducted to explore whether the protective effect of Salvianolic acid B (Sal B) on iopromide-induced human proximal tubular epithelial cells (HK-2 cells) injury is related to the inhibition of NLRP3 inflammasome (TRN: NL8582, registration date: 2020-05-01). Methods HK-2 cells were treated with several concentrations of iopromide or Sal B for 3 h, the cell viability was detected by Cell Counting Kit-8 (CCK-8) assay. The levels of reactive oxygen species and the mitochondrial membrane potential were evaluated by DCFH-DA and rhodamine 123 staining, separately. The nucleus morphology of apoptotic cells was observed by DAPI staining. The expression levels of inflammation and apoptosis related proteins were detected by Western blot. In addition, after the introduction of TLR4 inhibitor (TAK-242) to pretreat the cells, the above indicators were detected. The free energy and the docking amino acid residues between Sal B and TLR4 or NLRP3 were analyzed. Results Sal B can stably bind to TLR4 or NLRP3, counteract the decrease of cell viability and MMP, the increase of ROS, the number of apoptotic cells, and the expression levels of the above proteins which induced by iopromide. The effect of TAK-242 is similar to that of 100 µmol/L Sal B. However, the pre-treatment group with TAK-242 and Sal B at the same time had no significant difference in cell viability and apoptosis rate compared with the pre-treatment group with TAK-242 or Sal B alone. Conclusions Sal B can reduce iopromide-induced HK-2 cells damage through inhibiting NLRP3 inflammasome.

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“…Liu et al suggested that a high FAR strongly correlated with worse overall survival in renal cancer patients [20]. Another retrospective study explored a significant association between higher FAR and occurrence of AKI in patients undergoing percutaneous coronary intervention [15].…”

Section: Discussionmentioning

confidence: 99%

“…As a novel inflammation-based indicator, fibrinogen to albumin ratio (FAR) has gained prognostic value in various cancers [10][11][12] and myocardial infarction [13]. Additionally, several studies recently reported that FAR levels are associated with contrast-induced nephropathy and the occurrence of post-contrast acute kidney injury [14,15]. However, data on the association of the FAR with prognosis of AKI patients are limited.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of fibrinogen to albumin ratios among critically ill patients with acute kidney injury

Xia

Yao

et al. 2021

Intern Emerg Med

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Fibrinogen to albumin ratios (FAR) have shown to be a promising prognostic factor for improving the predictive accuracy in various diseases. This study explores FAR's prognostic significance in critically ill patients with acute kidney injury (AKI). All clinical data were extracted from the Multiparameter Intelligent Monitoring in Intensive Care Database III version 1.4. All patients were divided into four groups based on FAR quartiles. The primary endpoint was in-hospital mortality. A generalized additive model was applied to explore a nonlinear association between FAR and in-hospital mortality. The Cox proportional hazards models were used to determine the association between FAR and in-hospital mortality. A total of 5001 eligible subjects were enrolled. Multivariate analysis demonstrated that higher FAR was an independent predictor of in-hospital mortality after adjusting for potential confounders (HR, 95% CI 1.23, 1.03–1.48, P = 0.025). A nonlinear relationship between FAR and in-hospital mortality was observed. FAR may serve as a potential prognostic biomarker in critically patients with AKI and higher FAR was associated with increased risk of in-hospital mortality among these patients.

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Predictive Value of Fibrinogen-to-Albumin Ratio for Post-Contrast Acute Kidney Injury in Patients Undergoing Elective Percutaneous Coronary Intervention

Cited by 9 publications

References 14 publications

Fibrinogen and Atherosclerotic Cardiovascular Diseases—Review of the Literature and Clinical Studies

Fibrinogen and Atherosclerotic Cardiovascular Diseases—Review of the Literature and Clinical Studies

WITHDRAWN: Salvianolic acid B alleviates the injury of HK-2 cells induced by iopromide through inhibiting the activation of NLRP3 inflammasome

Prognostic value of fibrinogen to albumin ratios among critically ill patients with acute kidney injury

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