Predictive value of embryo grading for embryos with known outcomes

Weitzman, Vanessa N.; Schnee-Riesz, Jennifer; Benadiva, Claudio; Nulsen, John; Siano, L.; Maier, Donald

doi:10.1016/j.fertnstert.2009.02.032

Cited by 39 publications

(24 citation statements)

References 22 publications

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“…Chen et al [32] in 2006 showed that among the 1,186 zygotes evaluated, the best quality ones achieved the highest implantation rates, but the association did not achieve the statistical significance. In 2007 and in 2010, Nicoli et al [38] (including 1,032 zygotes) and Weitzman et al [45] (including 852 zygotes), respectively, confirmed the lack of statistically significant correlation between zygote morphology and rate of implantation. Finally, the most recent study conducted by Bar-Yoseph et al [47] in 2011 on 1,516 zygotes, concluded that zygote scoring was not a good predictor of implantation.…”

Section: Resultsmentioning

confidence: 93%

“…Twelve (52.2%) found a correlation [10,12,14,16,19,21,23,33],[36,39,40,43] between zygote morphology and implantation rate, while 11 studies (47.8%) did not find any correlation [15,17,26,28,30,32,34,38],[42,45,47]. …”

Section: Resultsmentioning

confidence: 99%

“…Current data on the usefulness of zygote morphology in IVF/ICSI procedures in which embryos are transferred from day 2 to day 6 reveled that zygote assessment gives limited additional information for the selection of the most competent embryos to transfer [5,35,45]. …”

Section: Discussionmentioning

confidence: 99%

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Pronuclear morphology evaluation for fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles: a systematic review

et al. 2013

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The current systematic review was aimed to assess the effectiveness of the zygote morphology evaluation in fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles. All available studies reporting on zygote morphology and clinical and/or biological outcomes were analyzed. Forty studies were included in the final analysis. Fourteen different zygote scoring systems were employed. Zygote morphology correlated significantly with embryo quality and cleavage, blastocyst stage, embryonic chromosome status, in a high proportion of the studies which assessed the specific outcome [15/25 (60%), 15/20 (75%), 7/8 (87.5%), 6/6 (100%), respectively]. On the other hand, only a reduced proportion of papers showed a statistically significant relationship between implantation, pregnancy and delivery/live-birth rates and zygote morphology score [12/23 (52.2%), 12/25 (48%), 1/4 (25%), respectively]. In conclusion, our findings demonstrate the lack of conclusive data on the clinical efficacy of the zygote morphology evaluation in fresh IVF/ICSI cycles, even if biological results showing a good relationship with embryo viability suggest a role in cycles in which the transfer/freezing is performed at day 1.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

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Pronuclear morphology evaluation for fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles: a systematic review

et al. 2013

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“…Cell number and embryo grade are more predictive of implantation rate than PN morphology in a study of 852 embryos when all or none of the embryos implanted [18]. Nicoli et al, 2007 found that 1,078 PN-scored embryos showed no relationship between PN patterns and embryo quality or clinical pregnancy [27].…”

Section: Discussionmentioning

confidence: 99%

“…Pattern 0 [6] and Z1 or Z2 [10] have been associated with an increase in implantation and pregnancy rates [7,8,[11][12][13][14][15]. Recently however, a number of investigators have not been able to demonstrate an association between PN scoring and improved ART outcomes [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Embryo quality but not pronuclear score is associated with clinical pregnancy following IVF

Berger

Zapantis

Merhi

et al. 2014

J Assist Reprod Genet

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Purpose The association between pronuclear (PN) scoring of embryos from assisted reproductive technology (ART) and clinical pregnancy remains controversial. We hypothesized that embryos with PNs scored on the day of fertilization check offer better embryo selection on day 3 and higher CPR compared to non-PN scored embryos. Methods Patients (19-46 years) undergoing IVF/ICSI cycles at Montefiore's Institute for Reproductive Medicine and Health between January 2006 and December 2009 were included in our study. We analyzed fresh day 3 cycles only with autologous oocytes and partner's fresh sperm (n=344). A total of 1,899 embryos were included. We compared CPR from non-PN scored embryos (Group 1, n=835) with PN scored embryos (Group 2, n=1,064). Composite scores by patient were developed based on embryo disposition. We also assessed traditional embryo grading derived from cell number, fragmentation and cell symmetry. Data analysis included chi square and t test to determine if PN scoring was associated with improved CPR, and to compare the additional variables.Results CPR between Group 1 and Group 2 were not different (p=0.91). CPR was significantly associated with female age, number of mature oocytes retrieved, number of day 3 embryos and grade of embryos transferred on day 3 (p<0.05). Conclusion PN scoring was not associated with improved CPR in day 3 embryo transfers. Mean grade of transferred embryos continues to be a well-established, independent predictor of CPR. We conclude that further refinement of embryo grading by PN scoring is not beneficial.

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Morphological Assessment of Embryos in Culture

Critchlow¹

2018

Clinical Reproductive Science

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Predictive value of embryo grading for embryos with known outcomes

Cited by 39 publications

References 22 publications

Pronuclear morphology evaluation for fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles: a systematic review

Pronuclear morphology evaluation for fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles: a systematic review

Embryo quality but not pronuclear score is associated with clinical pregnancy following IVF

Morphological Assessment of Embryos in Culture

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