Predictive value of cord blood IgE levels in ‘at‐risk’ newborn babies and influence of type of feeding

Abstract

Summary Cord serum IgE levels were examined in 101 newborn infants ofatopic parents, and reviewed at the ages of 3, 6, 9, 12, 15, 18, 21 and 24 months, in order to determine any relation with signs and symptoms of allergic rhinitis, bronchial asthma, atopic dermatitis, urticaria and food allergy. Cord blood IgE levels were 1.06+ 1.02 U/ml in the group of infants who developed atopic disease, and 0.34 + 0.79 U./ml in the group of infants who did not develop atopy (P < 0.001). In the breast‐fed group 37.5, of the infants with cord blood IgE more than 0.8 U/ml and 11.5% with IgE below 0.8 U/ml had atopic disease. In the soy‐fed group 33.3% of the infants with cord blood IgE more than 0.8 U/m! and 15.8% with cord blood IgE less than 0.8 U/ml developed atopy. Ninety percent of the cow's milk‐fed infants with cord blood IgE above 0.8 U/ml and 16% with cord blood IgE below 0.8 U/ml showed atopy during the follow‐up period. No correlation was found between the IgE levels in maternal and respective cord blood.

In 2532 Children we Report the Developmental Factors Influencing the Development of Atopic Diseases

“…Therefore, it was proposed that the measurement of IgE by PRIST testing in infants or at birth would have a predictive value in the atopy development. Several investigators have demonstrated that the risk of developing atopic diseases was very high when the cord IgE level was above 0.5 IU/ml [5,8,9,12].Our data shows that a newborn can be considered at risk for atopy when the cord IgE level is above 0.8 IU/ml [5]. We have also shown that neonates of non atopic parents (0.032 + 0…”

“…Our data shows that a newborn can be considered at risk for atopy when the cord IgE level is above 0.8 IU/ml [5]. We have also shown that neonates of non atopic parents (0.032 + 0…”

“…not atopic vs O.295 + 5.12 IU/ml in the atopic newborns, p < 0.005) [5]. Recent prospective studies have shown that the most accurate predictive results are obtained when family history and cord IgE levels are evaluated together [9,12].…”

Asthma: epidemiology, etiology and risk factors

“…67,68,71 The influence of avoiding nutritional allergens during breastfeeding is also controversial. In some studies, exclusion Review of milk, eggs and fish from the maternal diet was associated with decreased atopic dermatitis in infancy, 72,73 but other studies found no association. 40,74,75 Studies following children to 4 years of age have demonstrated no effect of maternal dietary restriction during lactation on the subsequent development of atopic diseases, including asthma.…”

Significance of Immunoglobulin E in Umbilical Blood in Relation to an Allergic Family History, Seasonality, Child Immunity and the Impact of Applied Non-pathogenic E. coli on Children’s Microbiome

“…They may reduce mucosal pathogen and reduce the number of intraepithelial regulatory T lymphocytes on the epithelial surface and thus increase their antigen presentation [28]. The ability of probiotics to influence intestinal flora has been documented in many studies [13,21,26,[29][30][31][32][33][34][35][36][37].…”